Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"prodomain"”.
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Characterisation of Prodomains in the GDNF Family
… as larger precursors consisting of an N-terminal prodomain and a C-terminal mature domain – pro-TGF-β proteins. The mature domains dimerise via disulfide bonds to form active ligands. Furthermore, the prodomain can be cleaved from the mature domain through proteolysis. GDNF family members are …
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Analysis of a trichomonas vaginalis cysteine protease
… of CP1 were created to determine the role of the prodomain in targeting CP1 to vesicles.</p>
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Characterisation of BMP Processing and Signalling in Adipocytes
… This interaction likely involves the prodomain, as substituting BMP8B's prodomain with that of BMP10 enhances secretion. ProBMP8B is mainly cleaved at a consensus pro-protein convertase site near the mature ligand domain (R<sub>260</sub>TRR<sub>263</sub>↓), with alternative cleavage …
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Nanoparticle coatings for spatial and temporal control of cancer imaging and therapy
… nanoparticle self-assembly. 2) Prodomain nanoparticles are developed using removable coatings that veil nanoparticle-cell interactions, lengthen particle circulation times, increase tumor accumulation, and unveil nanoparticle surface domains upon cleavage by proteases in the …
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The structure of human pro-myostatin and molecular basis of latency
… member, TGF$\beta$1. Following cleavage of the prodomains by furin, pro-myostatin persists as a stable non-covalent complex which is resistant to the natural inhibitor follistatin and exhibits significantly weaker bioactivity than the mature growth factor. A number of distinct structural …
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Investigation of the therapeutic potential of recombinant BMP10 in an adult mouse model of HHT1 and the crosstalk between BMP and VEGF signalling
… and rescue disease phenotype. Methods: Human prodomain-bound BMP10 (pBMP10) was generated in-house. The mouse colony was transferred from Newcastle to Cambridge for rederivation. Adult Tg(Cdh5- cre/ERT2)1Rha; Engfl/fl mice were injected with tamoxifen to induce Eng knockout in endothelial …
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The development of stapled peptides as chemical tools to investigate activin A signalling and as antibacterial agents targeting MsbA-mediated efflux
… led to the identification of an activin A prodomain-derived stapled peptide that is able to inhibit activin A signalling in vitro. In addition, the effect of stapling on the secondary structures of the peptides was assessed, as was its effect on protease resistance. This work provides a …
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TRAF Regulation of Caspase-2-Dependent Apoptosis in Response to DNA Damage
… three lysine residues in the caspase-2 prodomain (K15, K152, and K153) important for its ubiquitination and complex formation. Together these results revealed a novel role for TRAF2 as a direct activator of caspase-2 apoptosis triggered by DNA damage.</p><p> During mitosis, when the cell …
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Deep forward and reverse phenotyping for genetic discovery in pulmonary arterial hypertension.
… I found a significant correlation between the prodomain-bound form of the bone morphogenic protein 10 (pBMP10) levels and the risk of developing systemic hypertension among patients with IPAH. In summary, deep clinical and computational phenotyping allowed me to devise homogenous groups of …
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Entwicklung und Evaluation von IgY-Antikörpern gegen die Metalloproteinase ADAM12
… structure, which is a “signal peptide”, a “prodomain”, a “metalloproteinase domain”, a “disintegrin domain”, a “cysteine-rich domain” and in case of ADAM12-L a additional “transmembrane domain” and a “cytoplasmic tail”. ADAM12 mainly functions as a mediator of cell to cell contact, such as …