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Showing 1 to 15 of 15 for “"procyanidins"”.
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Oligomeric cocoa procyanidins possess enhanced bioactivity compared to monomeric and polymeric cocoa procyanidins for preventing the development of obesity, insulin resistance, and impaired glucose tolerance during high-fat feeding
Flavanols are polyphenols that are known to have many beneficial effects on the body. Cocoa is a major source of these flavanols. However, research on the potential anti-obesity and anti-diabetic health benefits of cocoa flavanols is lacking in the literature. Furthermore, the effect that the size …
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Evaluation of Peanut Skin Extract, Grape Seed Extract, and Grape Seed Extract Fractions to Reduce Populations of Select Foodborne Pathogens
… results indicate that an extract with type B procyanidins that are high in oligomers may be more effective as antimicrobials. Type B procyanidins have also been shown to prevent bacterial adhesion, as is the case with urinary tract infections, and may aid in the prevention of biofilms.
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The Therapeutic Potential of Natural Products from <i>Vaccinium</i> Berries for Viral and Lung Diseases Through an Improved LC-MS-Based Chemometric Approach
… not been studied extensively – the oligomeric procyanidins. Procyanidin dimer B2 and an A-type trimer were found to counteract smoke-induced responses in airway epithelial cells by decreasing an inflammatory marker interleukin 8 (IL-8) and downregulating proteolytic enzyme collagenase matrix …
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Application and Characterization of Bioactive Compounds in Peanut Skins, a Waste Product of Virginia Agriculture
… MS determined the fractions to contain mostly procyanidins but also proanthocyanidins. Since it is possible for multiple compounds to display the same molecular ion, multistep MS and retention time differences were utilized to tentatively identify the compounds based upon their fragmentation …
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Elucidating the Molecular Mechanisms Underlying the Hepatic Farnesoid X Receptor (FXR)-mediated Effects that Contribute to the Triglyceride-Lowering Ability of a Grape Seed Proceyanidin Extract
Procyanidins are dietary flavonoids associated with reduced risk of cardiovascular disease, and function partially by reducing hypertriglyceridemia. Grape seed procyanidin extract (GSPE) was shown to decrease triglyceride levels via activation of the nuclear hormone receptor, farnesoid x receptor …
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Effects of Polyphenols on Vasomodulatory Factors and Associated Cell Signalling
… into its main polyphenol classes revealed that procyanidins were responsible for its bioactivity. These findings suggest that procyanidin-rich foods can improve markers of endothelial function in vitro. Further studies on procyanidin bioavailability are required to determine if these effects can …
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Identification and Quantification using HPLC-ES/MS of Four Pentacyclic Oxindole Alkaloids in Uncaria tomentosa Wild Type
… triterpenes, flavonoids, glycosides, and procyanidins. The metabolites in U. tomentosa are valuable in the treatment a number of diseases like bursitis, which is the inflammation of bursae (small sacs) of synovial fluid in the body, genital herpes, cancer, allergies, and those people …
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Colonic metabolism of dietary grape seed extract: Analytical method development, effect on tight-junction proteins, tissue accumulation, and pan-colonic pharmacokinetics
Procyanidins (PCs) have been extensively investigated for their potential health protective activities, but the prospective bioactivities are limited by their poor bioavailability. The majority of the ingested dose remains unabsorbed and reaches the colon where extensive microbial metabolism …
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Characterization, Interaction and Chemoprevention of Potent Constituents From Grape Cell Culture
… of TP-6 (comprised primarily of oligomenc procyanidins) using Sephadex LH-20, the cytotoxicity of bioactive subfractions to HepG2 human liver cancer cells was in a descending order of TP-6-5, TP-6-6 (similar potency to TP-6), and TP-6-4, suggesting that cytotoxicity of procyanidin mixtures …
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Gut Health Benefits of Natural and Alkali-Processed Cocoa (Theobroma cacao) with and without Inulin
… suggesting that alkalization may affect larger procyanidins more than smaller flavanol compounds. Inulin enhanced the inhibition of the PLA2 enzyme and enhanced the IL-8 anti-inflammatory properties of cocoa, although the trends were weak. Overall, we did not see any clear, significant effects …
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Phytochemical and toxocological studies of some Botswanan plants used in traditional medicine
… phenolics, phenolic glycosides, a component of procyanidins, a lignan glycoside and sugars. E. axillare yielded terpenoids, a secoiridoid, and sugars, whereas A. mexicana yielded alkaloids. Investigation of C. italica and J. erythropoda revealed the presence of terpenoids, flavonoids, glycosides …
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Supercritical Fluid Extraction Directly Coupled with Reversed Phase Liquid Chromatography for Quantitative Analysis of Analytes in Complex Matrices
… linked (B-type) and doubly linked (A-type) procyanidins were identified by LC-ESI-MS, as well as their galloylated derivatives. Compared to the off-line SFE-LC approach, much less sample was required for extraction in the on-line method, since all the extracted components could be …
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Evaluation of cocoa (Theobroma cacao) bean processing strategies to enhance alpha-glucosidase inhibitory activity of dietary cocoa
Cocoa beans (Theobroma cacao) are a highly concentrated source of dietary flavanols- bioactive compounds associated with the health protective properties of cocoa. Cocoa beans undergo processing steps, such as fermentation, roasting, winnowing, grinding, pressing, etc., to produce a final product …
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Anti-Diabetic and Anti-Obesity Activities of Cocoa (Theobroma cacao) via Physiological Enzyme Inhibition
Fermentation and roasting of cocoa (Theobroma cacao) decrease levels of polyphenolic flavanol compounds. However, it is largely unknown how these changes in polyphenol levels caused by processing affect cocoa's anti-diabetic and anti-obesity bioactivities, such as inhibition of certain enzymes in …
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Grape powder attenuates the negative effects of GLP-1 receptor antagonism by exendin-3 (9-39) in a normoglycemic mouse model
Prediabetes is a condition affecting 35% of US adults and about 50% of US adults age 65+. Foods rich in polyphenols, including flavanols and other flavonoids, have been studied for their putative beneficial effects on many different health conditions including type 2 diabetes mellitus and …