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Showing 1 to 20 of 33 for “"procollagen"”.
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Procollagen Folding in Health and Disease
Procollagen is a large, complex, and in many ways, unusual protein that is ubiquitous in the human body and in all animals. Decades of research have advanced our understanding of how cells fold and secrete this protein, nonetheless, many questions remain concerning procollagen biosynthesis, and how …
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Transcriptional regulation of the human alpha 2(I) procollagen gene
… coding for these trans-acting factors. α2(1) procollagen gene expression was examined in a number of diff erentiate<;l cell lines and shown to differ significantly between normal fibroblasts (WI-38, FG₀), transformed fibroblasts (CT-1, SVWI-38), HT1080 fibrosarcoma, HepG2 hepatocellular …
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Characterisation of the human α2(I) procollagen promoter-binding proteins
… that regulate the expression of the human α2(I) procollagen gene, cis-acting DNA-elements within the proximal promoter were identified and their corresponding trans-acting factors characterised. The fibroblast cell lines used in this study had previously been transformed with either simian virus …
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Procollagen Biosynthesis and Osteoblast Malfunction in the G610C Mouse Model of Osteogenesis Imperfecta
Osteogenesis imperfecta (OI) is a hereditary disease that disrupts bone formation and function resulting in skeletal deformities and fragile bones. OI is diagnosed based on clinical and radiological examination, with patient symptoms ranging in severity from relatively mild (increased incidence of …
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Characterisation of CIS- and trans-acting factors that regulate the human alpha 2(1) procollagen gene
The differential expression of the a2(I) procollagen gene in normal and transformed human fibroblasts has been correlated with differential in vitro DNA-protein interactions on the basal promoter region between -100 and -67. A 23 bp region of the a.2(1) procollagen promoter encompassing the G/CBE …
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The C-Propeptide in Collagen Proteostasis
… the N-glycan facilitates interaction between procollagen and ER lectin chaperones to ensure proper folding of misfolding-prone collagen variants or wild-type collagen under proteostatic stress. In Chapter 3, we present progress towards understanding the molecular mechanisms of collagen …
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Analisi morfologica e molecolare di cellule da colture primarie umane esposte a resine biocompatibili
… variability in the expression and synthesis of procollagen α1 type I and tenascin proteins on HGFs and HPFs treated with HEMA at different concentrations immunofluorescence, RT-PCR and western blot analysis, were carried out. The treatments on HGFs with 3mmol/L HEMA, showed a strong reduction of …
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RUOLO DELLA STIMOLAZIONE VAGALE SULLA PROLIFERAZIONE DEI FIBROBLASTI CARDIACI IN VIVO IN MODELLO ANIMALE DI FIBRILLAZIONE ATRIALE.
… 60 days (AF + Ang II). Results α1(I) and α1(III) procollagen mRNA levels increased statistically significant in the groups with atrial fibrillation associated or not with VNS in contrast with the group in sinus rhythm. The treatment with Angiotensin II receptor antagonist decrease proportionally …
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Changes in serum histologic surrogate markers and procollagen III N- terminal peptide as independent predictors of HBeAg loss in patients with chronic hepatitis B during entecavir therapy
… 12 months of entecavir treatment RESULTS: The procollagen III N-terminal peptide (PIIINP) and TIMP1, MMP2, hyaluronic acid and cytokeratin 18 fragment levels were significantly decreased and the haptoglobin level was significantly increased from baseline after entecavir treatment. Multivariate …
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Identifying the Molecular Cause of Extreme Endoplasmic Reticulum Dilation in Pediatric Osteosarcoma and Its Relationship to the Disease
… that has resulted in the accumulation of procollagen-I protein within ‘hallmark’ dilated ER. Using CRISPR activation technology, increased expression of only SAR1A and SEC24D to physiologically normal levels was sufficient to restore both collagen-I secretion and resolve dilated ER …
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An Analysis of the Collagen Synthesized by Chondrocyte Cultures Derived From the Chick Embryo Tibiotarsus
… fractions. The CM-collagen fraction contains procollagen and the intermediates in its metabolic maturation to {(alpha)1(II)}(,3) collagen. The Ma-collagen fraction contains mostly the pN-collagen and fully processed collagen. Small amounts of other bands that have a mobility slightly slower …
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Serum markers for predicting significant necroinflammatory activity in patients with chronic hepatitis B
… identified the ALT, hyaluronic acid (HA) and procollagen III N-terminal peptide (PIIINP) as independent predictors of significant inflammation (grade≥3). We constructed a formula for predicting significant inflammation. A significant inflammation (SI) score = 1.773 × ALT score + 1.599 × PIIINP …
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The Role of Lipid-Free Apolipoprotein A-I and PCPE2 in HDL Metabolism
… the role of apolipoprotein apoA-I (apoA-I) and procollagen C-endopeptidase enhancer 2 (PCPE2) in high density lipoprotein (HDL) metabolism. ApoA-I comprises ~70 percent of the protein within HDL and has an essential role in cholesterol efflux from peripheral cells as part of the reverse …
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Characterization Of The Skeletal Phenotype In Idua-W392X Knock-In Mice: Bone Metabolism Biomarkers
… activity, levels of the bone formation marker Procollagen type I N-terminal propeptide (PINP) were evaluated. To investigate osteoclast activity, levels of the bone resorption biomarker Tartrate-resistant acid phosphatase (TRAP5b) were evaluated. Potential differences in serum PINP or serum …
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Photorejuvenation Induced by 5-Aminolevulinic Acid Photodynamic Therapy in the Patients with Actinic Keratosis: A Histological Analysis
… increased with expression of type I and III procollagen. The level of transforming growth factor ？] and transforming growth factor ？？ type II receptors were also increased. The elastotic material with co-localizing fibrilline-1 and tropoelastin expression in the dermis tended to decrease …
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Role of sedlin, a TRAPP complex subunit, in membrane trafficking and in the pathogenesis of Spondyleopyphiseal Dysplasia Tarda
… chondrocyte- specific cargoes, such as type II procollagen (PCII). This hypothesis was reinforced by the fact that mutations in PCII give rise to autosomal dominant forms of spondyloepiphiseal dysplasia. I tested this hypothesis by analyzing the involvement of sedlin in the transport of …
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MIT/TFE FACTORS CONTROL ER-PHAGY VIA TRANSCRIPTIONAL REGULATION OF FAM134B
… with an abundant ER, producing predominantly procollagen (PC) molecules in extracellular matrix during endochondral ossification. They reside in a poorly vascularized tissue, as the growth plate, with scarcity of nutrients, representing a good cellular model to study ER-phagy. We found that …
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The Effects of Dietary N-3 Polyunsaturated Fat from Plant Versus Marine Sources on Bochemical Markers of Bone Turnover in Healthy Adults
… markers of bone turnover [c-telopeptide (CTX); procollagen Type I N-terminal propeptide (PINT); and osteocalcin (OC)] were analyzed in serum at the end of each diet period in both studies.</p> <p><strong>Results:</strong>There were no significant changes in serum CTX, P1NP, and OC among the …
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Photo-biomodulation of human skin fibroblast sub-populations: a systematic approach for the optimization of optical treatment parameters
… level, 450-nm light inhibited the production of procollagen I in human reticular and papillary fibroblasts in a dose-dependent manner. Gene expression results were in agreement i.e., the same light parameter down-regulated collagen fiber genes, integrins and up-regulated collagenase MMP1. This …
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