Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"prochlorosin"”.
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Mechanistic and synthetic studies on the prochlorosin and cytolysin families of lanthipeptides
Peptides are an attractive class of therapeutics, occupying a niche between small molecules and biologics. Research in the van der Donk lab focuses on lanthipeptides, a class of ribosomally synthesized and post-translationally modified peptides (RiPPs) that commonly feature antibacterial activity …
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Ecology and evolution of lanthipeptides in marine picocyanobacteria
… function of many lanthipeptides remains unknown. Prochlorosins are a diverse group of lanthipeptides produced by strains of the ubiquitous marine picocyanobacteria Prochlorococcus and Synechococcus. Unlike other lanthipeptide-producing bacteria, picocyanobacteria utilize an unprecedented mechanism …
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Structural investigation of lanthipeptides involved in substrate controlled pathways and methods for leader peptide removal
… This study characterizes for the first time five prochlorosins, which adopt different globular structures, as well as the two component cytolysin peptides, which adopt helical conformations consistent with traits previously shown to be important in membrane permeabilization by other helical …
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Use of solution-state nuclear magnetic resonance spectroscopy to determine the structures of medicinally relevant peptides and proteins
… The first system studied was that of the prochlorosins, an unusual family of lantipeptides all modified to their mature form by a single lantibiotic synthetase. Next was the two peptide lantibiotic cytolysin, unique among bacteriocins in that it has hemolytic activity in addition to …
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New chemical and biosynthetic methodologies for the study of lanthipeptides
Recent genome sequencing efforts have revealed that a common biosynthetic route to peptide natural products involves ribosomally synthesized and posttranslationally modified peptides (RiPPs). One of the largest classes of RiPPs is the lanthionine-containing peptides (lanthipeptides), which are …