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Showing 1 to 3 of 3 for “"procapsid"”.
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Structure of the GP16 ATPase from the φ29 dsDNA packaging motor
… DNA (dsDNA) into a preformed viral shell, or procapsid, and serves as a model system for studying genome packaging in eukaryotic dsDNA viruses such as poxviruses, herpesviruses and adenoviruses. Encapsidation of bacteriophage φ29 DNA is driven by a phage-encoded molecular motor. This motor is …
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Cooperative Assembly of Terminase and Integration Host Factor at the Packaging Initiation Site of Bacteriophage Lambda
Packaging of viral genomes into procapsids by terminase enzymes is conserved in many DNA viruses. Terminases bind to linear concatemers of replicated viral genomes and concomitantly excise (mature) and package a single genome per procapsid. In this thesis, I interrogate the role of E. coli …