Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"pro-inflammatory mediator"”.
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Immunomodulatory activity of Lacticaseibacillus rhamnosus R0011: analysis of secretome-mediated impacts on innate immune outcomes in intestinal epithelial cells and antigen presenting cells
… activities including down-regulation of pro-inflammatory gene transcription and expression. While host intestinal epithelial cells (IECs) and antigen-presenting cells (APCs) can interact directly with both commensal and pathogenic bacteria through innate immune pattern recognition …
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Integrating inflammatory stimuli with macromolecules for therapy and sensing of vascular diseases
… condition. Biochemical signals elicited under inflammatory conditions are considerably different from those under normal circumstances. Molecules such as pro-inflammatory mediator TNFα and reactive oxygen species are powerful triggers to several signaling mechanisms. In this regard, the overall …
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Development of a superabsorber based haemofiltration technology for use in paediatric cardiac surgery
… in the interstitial space (edema). Theassociated inflammatory response can, in severe cases, result in systemic immune responsesyndrome, acute respiratory distress syndrome, and organ failure.Modified Ultrafiltration (MUF) involves pumping blood through a haemofilter post-bypass toremove excess …
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Investigations into the influence and role of tissue factor in the pathogenesis of myocardial hypertrophy
… plays an important role in the induction and/or progression of cardiac hypertrophy. The aim of this thesis was to examine the relationship between TF and the onset of cardiac hypertrophy. Cardiac hypertrophy was achieved by aortic constriction in male Sprague-Dawely rats. TF levels increased in …
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Inhibition of TLR4 minimizes islet damage due to sterile inflammation and improves islet transplant outcomes.
… for brittle type 1 diabetes and as an adjunct procedure after total pancreatectomy to prevent brittle diabetes. The efficacy and long-term function of islet transplantation have significantly improved over the last two decades. However, transplant outcomes are still largely compromised due to …
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Characterization of Innate Immune Mechanisms Against RVFV and a Potential Target for Antivirals
… and S- segments). NSs, encoded in the S- segment promotes degradation of PKR and general transcription shutoff including IFN-β mRNA synthesis. Currently, no effective measures have been developed to prevent or treat RVFV disease and very little is understood about what takes place during the …
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Role of the NLRP3 Inflammasome in bacterial keratitis
… in inflammation and infection and are known to produce the NLRP3 inflammasome. The NLRP3 inflammasome produces IL-1β a key pro-inflammatory mediator. The phenomenon of macrophage polarization during bacterial keratitis is not known, nor is the consequence of inhibiting the production of IL-1β …
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Role of ß-catenin and Leukotriene in Colon Cancer Progression
… risk factors for development of colon cancer is inflammatory bowel disease. Inflammatory microenvironment is an essential component of most tumors. Interestingly, high levels of the pro-inflammatory mediator leukotriene D4 (LTD4) in association with its receptor CysLT1 goes with poor prognosis …
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The Novel Function of Creatinine Acting as an Anti-Inflammatory Immunomodulator and Antioxidant
… in vitro that CRN has some immunomodulatory properties. To further delineate the immunomodulatory properties of CRN, we used real time-polymerase chain reaction and immunohistochemical staining to determine the mRNA and protein expression of tumor necrosis factor-α (TNF-α), a potent …
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Dissecting the anti-allergic potential of carnosic acid during IgE and IL-33-mediated mast cell activation
… by the immediate degranulation of preformed mediators and the delayed production and release of pro-inflammatory cytokine and chemokines. As a result of mast cells being the main perpetrators of the inflammatory responses associated with allergy, identifying novel mast cell stabilizing …
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Diverse roles of cyclooxygenase in the central nervous system and the periphery
… (COX) is a rate limiting enzyme for prostaglandin (PG) synthesis. As inflammatory mediator, COX-2 and its product PGs modulate cytokines, chemokines and adhesion molecules in periphery and central nervous system. In the brain, COX-2 is increased by neurodegenerative disease and …
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Inhibition of Monocyte Chemotaxis and Chemokine Macrophage Inflammatory Protein-1 Alpha, and Interleukin-8 Secretion by Lipopolysaccharide Isolated from Periodontal Pathogens
… mechanisms of the immune system by secreting products that interfere with signals that promote chemotaxis of leukocytes enabling the pathogens to go unrestricted. When LPS binds to the Toll‑like receptor it promotes the secretion of proinflammatory cytokines in cells such as the macrophage, …
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Studies on the Function of Human Anti-HSP60 Monoclonal Antibody Fab
"목적 : 열충격 단백질(Heat Shock Protein; HSP)은 원핵 세포과 진핵 세포에서 발현된다. 열충격 단백질은 단백질이 합성될 때 올바른 접힘을 돕는 chaperone의 역할을 하며 분자량에 따라 나뉠 수 있다. 그 중에서 열충격 단백질-60은 열과 같은 충격에 의하여 미토콘드리아 내에서 발현 양이 증가되고, 세포 표면에서도 발현될 수 있다. 열충격 단백질-60은 다양한 미생물질에 의한 선천적 면역 체계 활성체 및 염증 반응 자극제로서 작용한다고 알려졌다. 인간 재조합 열충격 단백질-60은 면역 세포에서 염증 반응을 …
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Pharmacological profiling of novel melanocortin peptides targeting the hMC1, hMC3 and hMC5 receptors in 2-D and 3-D models of activated chondrocytes
… The pathology of OA is mediated by a complex inflammatory response predominantly driven by elevated levels of interleukin-1beta (IL-1b), in addition to tumour necrosis factor-alpha (TNF-a). Endotoxins such as lipopolysaccharide (LPS), or Nitric Oxide donors such as …
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Characterising epithelial to mesenchymal transition and pro-fibrotic processes in chronic obstructive pulmonary disease
… irreversible disease reducing lung function via processes of inflammation, emphysema and fibrosis. Patient treatment options are limited including bronchodilators and inhaled corticosteroids that are poorly effective. Linked with a significant history of cigarette smoking, pathology is …