Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 167 for “"pro-inflammatory cytokine"”.
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Characterizing the pro-inflammatory cytokine response by dendritic cells upon exposure to PrP proteins
… on DC activation by measuring TNFα and IL-12 production. There was no significant production of TNFα or IL-12 by bone marrow derived DCs (BMDC) after exposure to PrPSc infected brain homogenate, however, BMDCs had lower capacity to produce IL-12 after secondary stimulation with LPS. …
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Cell death and Pro-inflammatory Cytokine Release of Rat Microglial Cells by Naegleria fowleri
… by (51)^Cr release assay. In addition, the pro-inflammatory cytokine release from microglial cells in co-culture system was estimated. As results with a light and electron microscopes, most of microglial cells were severely destroyed by N. fowleri lysate, showing the necrotic (above 85%) and …
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The role and host-directed targeting of long non-coding RNAs in macrophage polarization during Mycobacterium tuberculosis infection
… and human macrophages by a loss-of-function approach using chemically engineered antisense oligonucleotides (gapmeRs). Knockdown of lncRNA-125 by gapmeRs reduced Mtb growth and anti-inflammatory cytokine production mediated by increased apoptosis, nitrite and pro-inflammatory cytokine …
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The innate response to fungal infection
… and TLR2 receptors, ultimately resulting in pro and anti-inflammatory cytokine production.<br/>Following Dectin-1 activation, I show that blocking SYK activity with SYK inhibitor II<br/>prevents MAPK and NF?B signalling, causing a reduction in both pro and antiinflammatory cytokine …
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EFFECTS OF OSTEOARTHRITIS AND INFLAMMATION ON MENISCUS CELL RESPONSE TO OSTEOGENIC PROTEIN 1 (OP1)
The long term objective of this project was to determine the response to the Bone Morphogenic Protein (BMP) family member, Osteogenic Protein 1 (OP1/BMP7) in meniscus cells. We have focused on the meniscus, because this tissue is highly susceptable to injuries which often fail to heal and lead to …
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Mechanisms of imporvement following functional inhibition of nitrosative stress after brun and smoke-induced acute lung injury
… species (ROS/RNS) that in turn drives an inflammatory response and consequently cell death through hyper-activation of poly (ADP-ribose) polymerase (PARP-1). The purpose of this study was to investigate and counteract pulmonary dysfunction associated with nitrosative stress generated after …
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Bacterial and host dynamics of Mycoplasma genitalium infection of the human female reporductive tract
… pathogen that is associated with several inflammatory syndromes including cervicitis and pelvic inflammatory disease. Despite the clinical associations of MG with inflammatory sequeale, no experimental evidence was available for the capacity to establish infection of the female …
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Mechanisms of Immuno-Modulation With The TLR4 Agonist Monophosphoryl Lipid A in the Treatment of Sepsis
… a Toll-like receptor 4 agonist that has been approved for use as a vaccine adjuvant in humans. In these studies, we evaluated the effect of MPLA treatment on the innate immune response to systemic infection in mice with emphasis on bacterial clearance, leukocyte recruitment and function, as well …
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Equine obesity-related hyperleptinemia
… on these observations, three experimental approaches were used to further study equine obesity-related hyperleptinemia. The first experiment determined the prevalence of hyperleptinemia among postpartum, lactating mares, evaluated its consequence on their re-breeding success, and investigated …
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Identifying a Target Protein and Ligands for Autoimmune Disorders
… is an autoimmune disorder characterized by unprovoked inflammatory responses that lead to tissue degradation. Patients suffering from SLE display an overexpression of master regulatory protein HIF-1 HIF-1is a transcription factor for pro-inflammatory cytokine interleukin-17A (IL-17A), which is …
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Thymoquinone is a Novel Ligand which Activates Neu4 Sialidase to Promote a Pro-Inflammatory Response
… and prevention. TQ is believed to share similar properties to the benzoquinones already in use as therapeutic drugs. Based on previous reports on the anti-inflammatory properties of black seed oil and TQ, it was originally hypothesized that TQ would inhibit lipopolysaccharide (LPS)-induced …
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Development and Characterisation of an Immunocompetent Three-Dimensional Oral Mucosal Infection Model
… Macrophages exist within a regulatory to inflammatory polarisation spectrum, whereby the local microenvironment determines their activity, contributing to the overall behaviour of a tissue. Three-dimensional oral mucosal models were formed using primary (POK) or immortalized (HaCaT) …
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Inflammatory Proteins, Genetic Variation, and Environmental Influences on Health Care Associated Infection Development in Sepsis
… the impact of baseline systemic inflammation (pro‑inflammatory cytokine, anti‑inflammatory cytokine, and their ratio), genetic variability, and environment on the development of health care associated infections (HAI) among sepsis patients during their ICU stay (up to 28 days).</p> …
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Protective effect of TM-25659, known as TAZ activator, on high-fat diet-induced insulin resistance in C57BL/6J mice
… muscle 33 F. TM-25659 lowered the muscle pro-inflammatory cytokine levels in DIO mice 35 G. TM-25659 regulates expression of both FGF21 mRNA and protein in DIO mice skeletal muscles 37 Ⅳ. DISCUSSION 38 Ⅴ. CONCLUSION 42 PART 2. Protective effects of TM-25659 on high-fat diet-induced insulin …
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ESTROGEN, VASCULAR INFLAMMATION, AND INTERLEUKIN-17 IN RELATION TO ATHEROSCLEROSIS IN A FEMALE NONHUMAN PRIMATE MODEL
… cells and interleukin-17A (IL-17A), a signature pro-inflammatory cytokine for Th17, in atherosclerosis is unknown. Postmenopausal estrogen therapy (ET) mediates atheroprotection in part through anti-inflammatory effects; however, the effects of ET on Th17 cells and IL-17 are poorly understood. …
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Fumarate Inhibits TNF-α Release
… in cellular receptor activation and acute pro-inflammatory cytokine release. Inflammatory macrophages engage bacterial endotoxins, including Gram-negative lipopolysaccharide (LPS) and Gram-positive lipoteichoic acid (LTA). And respond by releasing tumor necrosis factor-α (TNF-α). While …
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Role of miR-19a-3p and miR-19b-3p in microglia activation and neuroinflammation
… system, triggers neuroinflammation through the production of pro-inflammatory cytokines, contributing to neuropathic pain. The relationship between inflammation and pain is well-established, and the neuroinflammatory effects of SCI are key to the chronic and intense pain experienced by many with …
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Modulation of macrophage metabolism and function by the helminth peptide FhHDM-1
… characterisation of the liver fluke’s secreted proteins identified a peptide (termed FhHDM-1) that inhibited progression of immune-mediated disease in murine models of diabetes, multiple sclerosis and asthma. The aim of this PhD project was to uncover the mechanisms by which FhHDM-1 was …
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Idiopathic Intracranial Hypertension
… and management controversial, due to the lack of prospective trials. This thesis provides a comprehensive review of the aetiology and management of IIH. The hypothesis that IIH is associated with a pro-inflammatory cytokine profile, suggested by its established association with female gender and …
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Regulation of macrophage subsets in homeostatic and inflammatory mucosal environments
… such as E. coli. In the case of mucosal inflammatory pathologies, such as Crohn’s disease, this state of tolerance is broken, resulting in destruction of gut mucosal tissue where the macrophage phenotype has been altered from a regulatory M2-like subset phenotype to an inflammatory …
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