Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"pro-coagulant"”.
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Targeting phosphatidylserine exposure in pro-coagulant platelets.
Pro-coagulant platelets are a subpopulation of activated platelets that are central to blood clot formation in both thrombosis and haemostasis. They expose the anionic phospholipid, phosphatidylserine (PS), in their outer leaflet enabling coagulation complex assembly on the negatively charged …
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Inhibiting platelet scramblase activity
… populations of activated platelets form, pro-aggregatory and pro-coagulant platelets. Pro-aggregatory platelets have active integrins and aggregate together via fibrinogen to form the haemostatic plug which prevents bleeding. Pro-coagulant platelets expose phosphatidylserine (PS) which …
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Mechanisms of microparticle release from human platelets
… thesis aims to resolve the mechanisms by which pro-thrombotic microparticles are released from platelets, which have not been well-characterised. Experimental methods used include flow cytometry, Western blotting, fluorescence-based microplate assays, confocal microscopy and electron microscopy. …
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Effect of resection of localised pancreatic cancer on tissue-factor promoted pathways of thrombosis, cell invasion and angiogenesis
… malignancy in the UK but it has the poorest prognosis of all human adenocarcinoma. The autopsy, epidemiological and clinical studies have consistently identified PC as one of the most highly angiogenic and invasive malignancies, with the greatest prevalence and incidence of thrombo-embolism …
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Novel Sulfated 4-Hydroxycinnamic Acid Oligomers as Potent Anticoagulants
… 4-hydroxycinnamic acids (DHPs) as potential anticoagulants. Oligomers were prepared through peroxidase-catalyzed oxidative coupling of 4-hydroxycinnamic acids. The products resulting from this reaction are called CDs, FDs and SDs. Structurally, these sulfated DHPs are unique and do not resemble …
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Streptococcus pyogenes - a manipulator of human defences
… or manipulating the host defence systems to promote its own survival. A major virulence determinant of S. pyogenes is the cell surface attached M protein. It has previously been shown that M proteins of certain serotypes form complexes with fibrinogen and that these can elicit a pathological …
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¿ROLE OF ENDOTHELIAL DYSFUNCTION IN THE PATHOGENESIS OF UNPROVOKED VENOUS THROMBOEMBOLISM¿
… conditions and are therefore classified as unprovoked VTE (uVTE). Being uVTE pathogenesis still unknown, uVTE patients are characterised by a high risk of recurrence, and the therapeutic management of these patients to prevent VTE recurrence is still controversial. A better comprehension of …
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Fatty acid regulation of adhesion molecule expression in human vascular cells.
… branches and curvatures. Endothelial dysfunction produces an endothelium with pro-coagulant properties, which releases inflammatory cytokines and vasoactive molecules that produce an inflammatory reaction. The endothelium becomes increasingly permeable to LDL and an increase in adhesion molecule …