Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"pro-antibodies"”.
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Engineering of an anti-PAI-1 antibody with tissue specific activation
… activity causes dose-limiting toxicities. A pro-antibody, inspired by naturally occurring, proteolytically activated pro-forms of endogenous proteins, is an antibody variant which remains masked for antigen binding until activated locally by an organ-selective protease. This approach is …
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FROM ANTIBODY-DRUG CONJUGATES TO MASKED ANTIBODIES: BIOPHYSICAL INSIGHT FOR THE RATIONAL DESIGN OF FUTURE THERAPIES
Monoclonal antibodies have become a major class of therapeutics over the past twenty-five years and, during this time, many successful antibody scaffolds have been based on wild-type humanized and human sequences of the immunoglobulin G isotype 1 (IgG1) subclass. In the past, several mutations have …