Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"privileged scaffold"”.
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Suzuki-Miyaura mediated biphenyl synthesis: a spotlight on the boronate coupling partner
… widely encountered in medicinal chemistry as a privileged scaffold. The palladium-catalysed Suzuki-Miyaura (SM) coupling is one of the most important and efficient strategies for the synthesis of symmetrical and unsymmetrical biaryl compounds; the arylboronic acid or ester is a key partner in …
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Light-Mediated Dual Catalysis for C–N Bond Formation
… transformation to generate b-phenylethylamine scaffolds, a valuable motif that is found in a range of pharmaceutically active compounds, is presented. 1,2 This was achieved through the design of a visible- light mediated dual-catalytic platform that enabled multicomponent coupling of alkenes, …
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Synthesis, physicochemical and biological evaluation of N-dealkylated metabolites of antimalarial pyrido[1,2-a]benzimidazoles and related compounds containing a Mannich base side-chain
… of novel antimalarials. The benzimidazole scaffold is an extensively researched privileged scaffold in medicinal chemistry because of its capacity to interact with numerous biological systems in various diseases, including malaria. Based on previous metabolite identification studies in …
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Selective Borylations of Carbon-Carbon pi-Bonds
… boron on the electron withdrawing allenoate scaffold as well as on disubstituted 1,3-diynes. Lastly, this dissertation will cover the preliminary anti-fungal activity of a novel oxaborole scaffold. We investigated the borylation of the electron withdrawing allenoate scaffold. Reports in the …
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Discovery and Development of a Three-Component Oxidopyrylium Cycloaddition and Its Application Towards alpha-Hydroxytropolone Synthesis
… of previously unknown biologically active scaffolds. A particular focus will be spent on the synthetic and biological endeavors made by our laboratory involving α-hydroxytropolones (αHTs).</p> <p>αHTs are a subclass of troponoid natural products that possess promising activity against a …