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Showing 1 to 2 of 2 for “"prioni"”.
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Modelli murini transgenici di malattie da prioni per lo studio del ruolo fisiopatologico della proteina prionica.
Inherited prion diseases are linked to mutations in the prion protein (PrP) gene that are thought to favor the conformational conversion of PrP into a pathogenic misfolded isoform. Each mutation is associated with a distinct disease phenotype, which is profoundly affected by the Met/Val …
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STUDIO DEL RUOLO DELLA PROTEINA PRIONICA NELLA REGOLAZIONE DEL SONNO MEDIANTE L'UTILIZZO DI MODELLI MURINI TRANSGENICI
Introduction: an inherited form of Creutzfeldt-Jakob disease (CJD) is linked to the D178N/V129 mutation in the prion protein (PrP) gene. CJD is usually characterized by motor disorders, cognitive impairment and electroencephalographic alterations but recently sleep modification have been described. …