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Showing 1 to 5 of 5 for “"prion strain"”.
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Mechanisms of Prion Strain Interference
Prion diseases are infectious neurodegenerative disorders that affect humans and other mammals and are inevitably fatal. The infectious agent in prion disease (PrPSc) is an abnormal isoform of an endogenous host protein (PrPC). Prion conversion involves a conformational change of PrPC into PrPSc, …
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Use of the Protein Misfolding Cyclic Amplification for food safety and drug discovery
<p>Prion diseases are fatal neurodegenerative disorders caused by the misfolding of the normal prion protein (PrP<sup>C</sup>) into its infectious form (PrP<sup>Sc</sup>). While the zoonotic potential of chronic wasting disease (CWD) remains uncertain, the presence of prions in food products raises …
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Deciphering the Molecular Basis of the Species Barrier in Prion Disease Using Bank Vole PrP
Prion disease is an infectious and fatal neurodegeneration condition which depends on the structural reconfiguration of a predominantly α-helical cellular protein called PrPC into a β-sheet rich conformer referred to as scrapie or PrPSc. The infectious nature of this conformer enables it to …
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Mechanism of yeast prion portein aggregation and strain formation
Misfolding and aggregation of the prion protein: PrP) causes fatal neurodegenerative diseases in many mammalian species, including humans. Mutations in the gene encoding PrP are associated with ~15% of the incidences, while, the vast majority of the cases are sporadic. Interestingly, prion diseases …
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Übertragung von BSE auf nicht humane Primaten als Modell für die variante Creutzfeldt-Jakob Erkrankung (vCJD) im Menschen
… infizierten Javaneraffen an einer Prionenerkrankung erkrankten. Im Vergleich mit verschiedenen humanen CJD-Subtypen konnte diese als vCJD identifiziert werden. Diese Ergebnisse bestätigen BSE-Material als Auslöser für vCJD. Zusätzlich wurden bei 2/6 Tieren Charakteristika …