Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"primordial follicles"”.
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Determine the developmental dynamics of primordial follicles in the mouse ovary
Ovarian follicles are the basic functional units of the mammalian ovary. Progressive activation of primordial follicles serves as the source of fertilizable ova. In this thesis, by generating the Foxl2-CreERT2 and Sohlh1-CreERT2 mouse models, I have specifically labeled and traced the in vivo …
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DEVELOPMENT OF PHYSIOLOGICAL CULTURE SYSTEMS TO ACCESS UNTAPPED OVARIAN RESERVES FOR IMPROVING REPRODUCTIVE EFFICIENCY
… Recreating folliculogenesis to grow a dormant primordial follicle to the preovulatory stage in vitro remains the most coveted goal of fertility preservation programs. The ability to grow undifferentiated oocytes in vitro from primordial follicles would increase the supply of fully grown oocytes …
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The effects of an environmentally relevant phthalate mixture on female reproduction
… mammals, females are born with a finite pool of primordial follicles, and the size of primordial follicle pool determines the reproductive lifespan. To form the finite pool of primordial follicles, germ cells must undergo mitosis, formation of germ cell nests, meiosis, and germ cell nest …
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Steroid hormone regulation of fetal mouse oocyte development
… maintenance of the non-renewable reservoir of primordial follicles in female mammals remain largely elusive. During the early stages of fetal development, oocytes grow in nests or clusters known as germ cell cysts. Cysts break down into individual oocytes in the perinatal period and become …
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The role of vascular endothelial growth factor isoforms in early follicle development
… vascularization of the theca layer increases as follicles progress in size through preantral and antral stages, the principal angiogenic factor, vascular endothelial growth factor A (VEGFA), may influence follicle growth via regulation of angiogenesis. However, VEGFA may also influence follicular …
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TRANSCRIPTOME LANDSCAPE OF EARLY FOLLICULOGENESIS IN MAMMALS: UNLOCKING THE INTERPLAY MECHANISMS TO ENHANCE ART EFFICIENCY IN FERTILITY PRESERVATION
… female gamete reserve, specifically the antral follicles. In contrast, the preantral follicle population, which represents 99% of the reserve, remains unexploited. To date, no established culture system has been successfully adopted to replicate folliculogenesis in vitro, as existing approaches …
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Mechanisms by which di(2-ethylhexyl) phthalate and mono(2-ethylhexyl) phthalate disrupt ovarian folliculogenesis and steroidogenesis
… are folliculogenesis and steroidogenesis. Follicles are the functional units of the ovary containing the oocyte required for ovulation and fertilization and somatic cells responsible for synthesizing sex steroid hormones. Folliculogenesis is the process by which follicles undergo several …
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Morphogenesis and Female Fate Determination in Vertebrates
… cells and somatic granulosa cells organize into primordial follicles, the structures that generate mature oocytes for ovulation in adult females. We investigated the embryonic origins and proliferative properties of granulosa cells in the fetal mouse ovary and found that the precursors emerge …
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The immediate and long-term consequences of temporary exposure during adulthood to di(2-ethylhexyl) phthalate and diisononyl phthalate on female reproduction
… a finite number of oocytes in the form of the primordial follicle pool. Primordial follicles are composed of an oocyte surrounded by supporting somatic cells. Activated primordial follicles will grow through the primary, preantral, and antral follicle stages before ovulating. Proper maintenance …
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Investigating mechanisms of ovotoxicity of Perfluorooctanoic acid and Zearalenone exposure and the influence of altered metabolic status on ovarian function
… discovered that obesity decreases the number of primordial follicles, alters steroidogenesis and folliculogenesis, altering the estrous cycle, and blunts the ovarian response to toxicant exposure. In this dissertation, the hypothesis that altered physiological status such as obesity or heat …
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The transgenerational effects of Di(2-ethylhexyl) phthalate on female reproduction in mice
… the ovary is a heterogeneous organ composed of follicles, oocytes, corpora lutea, and interstitial tissue. The primary roles of the ovary are to produce sex steroid hormones and maintain a steady stream of growing follicles. Normal sex steroid hormone production by the mature follicles is …
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The effects of adult exposure to genistein on female reproductive outcomes
… present in all stages ranging from the immature primordial follicle to the most mature antral follicle. The antral follicle is one of the most important follicle types because it is the primary producer of sex steroid hormones in the ovary, and it is the only follicle type capable of growing to …