Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"primate specific"”.
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Dissecting the regulatory roles and cellular functions of mammalian ZSCAN5B and primate-specific paralogs
… of divergent paralogous transcription factors in primate species. One such family is the ZSCAN5 subfamily, represented by a single, conserved founding member, ZSCAN5B, and clustered paralogs that arose early in primate history, and this clustered subfamily has been the subject of my thesis work. I …
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Primate-specific KRAB zinc finger proteins and their targets rewire regulatory networks related to inflammation and pancreas development
… pancreatic development and binds on members of primate conserved MER11 elements leading to their epigenetic silencing. On the other hand, ZNF267 is already highly expressed in monocytes and macrophages but it is further upregulated by inflammatory stimuli. ZNF267 ChIP data show that it mainly …
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Understanding the Conserved and Species-Specific Functions of FOXP2, a Gene Implicated in Speech and Language Development
… to better understand the conserved and human-specific functions of FoxP2. Intrigued by the enrichment of FOXP2 in the human subplate layer, I hypothesized that FOXP2 regulates evolutionarily distinct subplate gene expression patterns and tested this theory by performing RNA-seq in human …
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Molecular Mechanisms Controlling the Development and Evolution of the Human Cerebral Cortex
… of any terrestrial mammal. This is partly due to primate-specific and human-specific changes in the patterns of cortical progenitor proliferation and differentiation during development. The relative inaccessibility of human and primate cortical development has however hindered the study of the …
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Unlocking Compacted Heterochromatin Through Modulation Of Associated Proteins
… cell types exist in all cells, a given cell’s specific transcriptomic and proteomic landscape is controlled by an incredibly complex system of gene regulatory complexes and epigenetic marks which promote activation of cell-type specific gene expression profiles and silence alternative cell fate …
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A TRIM28 centric strategy to efficiently uncover the contribution of KZFPs to the evolution of gene regulatory networks
… elements (TEs). KZFPs bind TEs in a sequence specific manner and recruit TRIM28 which interacts with other proteins to add H3K9me3, inducing silencing-associated heterochromatin. Interestingly, it was discovered following a large-scale survey of their binding sites that most human KZFPs target …
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Pluripotency and patterning in nonhuman primate embryogenesis
… of this property of the early embryo. However, primate embryogenesis differs in anatomical architecture, developmental timing, and molecular configuration. Obvious ethical considerations limit human embryo research, thus nonhuman primates offer an opportunity to unravel primate-specific features …
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Transcriptomic Signatures of Projection Class Neurons for Vocal Control
… assembly for the common marmoset, anon-human primate that displays flexible vocal communication abilities in complex social settings as well as rudimentary neural circuits for vocal motor control. My findings demonstrate the power of using a trio-binning approach, in combination with long-read …
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Investigations into Why Human (but not mouse) KU70/80 is Essential Reveal a Role for Human KU70/80 in Ribosome Biogenesis
… of Ku70/80 for ribosome biogenesis in higher primates explains otherwise perplexing essential nature of this double-strand break (DSB) repair factor. We have ruled out telomere protection or DSB repair as the essential function ofKu70/80. Instead, unbiased genome-wide analyses pointed to a …
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Comparison of orthologs across multiple species by various strategies
… mammals and correspondingly, find the species-specific sets of genes or functions. However, comparative genomics can be feasible only if a meaningful classification of genes exists. A natural way to do so is to delineate sets of orthologous genes. However, debates exist about the appropriate …