Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"primary human hepatocyte"”.
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Building blocks for regenerative medicine : vascularized models and immunomodulation to engineer hepatic cell therapies
… sought to address two of these challenges: hepatocyte (liver parenchymal cell) sourcing and immune compatibility. The main hurdle in primary human hepatocyte sourcing is the loss of regenerative potential of the cells ex vivo.
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Effects of Liver Extracellular Matrix Gel Stiffness on Primary Hepatocyte Function
… the long term function and viability of cells. Primary liver epithelial cells, or hepatocytes, are easily isolated in large quantities. However, these cells quickly lose viability and function once removed from the native organ. In order to support hepatocyte phenotype in culture, decellularized …
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Understanding the transport mechanisms of BSEP to improve the prediction of DILI compounds
… function and expression level of BSEP. 2D and 3D primary cultured hepatocytes were used to establish the effect of DILI-inducing drugs on the synthesis of bile acids and their distribution across the cell and the media. Multivariate analyses of the data demonstrate that drugs can change the bile …