Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"primary amoebic meningoencephalitis"”.
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Characterization of cathepsin B cysteine protease from Naegleria fowleri excretory-secretory proteins exerting immunomodulatory effects
… can cause an acute fulminating hemorrhagic meningoencephalitis, called primary amoebic meningoencephalitis (PAM) in experimental animals and in humans. Pathogenicity of N. fowleri may be induced by contact-dependent and contact-independent mechanisms, and both mechanisms lead to death of …
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Inflammasome activation in THP-1 target cells triggered by pathogenic Naegleria fowleri
… known as the brain-eating amoeba, causes acute primary amoebic meningoencephalitis. During swimming and other recreational water activities, N. fowleri trophozoites penetrate the nasal mucosa and invade the olfactory bulbs, resulting in intense inflammatory reactions in the forebrain tissue. To …
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Cytopathic Effects of a Pathogenic Naegleria fowleri and an Anti-Nfa1 Antibody on Rat Microglial Cells
… fowleri, a free-living amoeba, causes fatal primary amoebic meningoencephalitis (PAME) in experimental animals and humans. On the pathogenic mechanisms of N. fowleri concerned with host tissue invasion, the adherence of amoeba to host cells is most important. The nfa1 gene (360 bp) was …
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Cell death and Pro-inflammatory Cytokine Release of Rat Microglial Cells by Naegleria fowleri
… fowleri, a free-living amoeba, causes fatal primary amoebic meningoencephalitis in humans and experimental animals. In previous study, N. fowleri trophozoites showed the highly cytopathic activity and cytotoxicity against rat microglial cells by the morphological observation and 51Cr release …
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Role of the Nfa1 Protein in Pathogenic Naegleria fowleri Co-cultured with Target Cells
… exists as a virulent pathogen which causes fatal primary amoebic meningoencephalitis (PAME) in experimental animal and humans. Using infected and immune mouse sera, we previously cloned an antigenic gene (called nfa1) from a cDNA library of N. fowleri by immunoscreening. The nfa1 gene had the …
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PROTEOMIC ANALYSIS OF TWO DIFFERENT STATES OF NAEGLERIA FOWLERI
… that cause a fatal disease in humans called Primary Amoebic Meningoencephalitis (PAM). Mechanisms of host resistance or susceptibility to infection have not been fully elucidated, and possible treatment methods are still sub optimal. The disease is diagnosed using specific laboratory tests …
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Production and characterization of monoclonal antibodies against cathepsin B and cathepsin B-Like proteins of Naegleria fowleri
파울러자유아메바(Naegleria fowleri)는 원발성 아메바성 수막뇌염(primary amoebic meningoencephalitis; PAM)을 일으키는 병원체이다. 파울러자유아메바의 사람이나 실험 동물에 감염은 아메바가 오염된 물에서 물놀이 혹은 수중활동을 할 때 비강내로 아메바 영양형이 유입될 때 일어난다. 파울러자유아메바의 병인기전으로는 숙주세포와 접촉하여 사멸에 이르게 하는 접촉성 병인기작과 여러가지 단백분해효소를 분비하여 숙주세포에 영향을 주는 비접촉성 병인기작으로 알려져 있다. 파울러자유아메바의 시스테인 …
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Expression of inflammasome-related molecules from U87MG cells cocultured with Naegleria fowleri in the non-contact system
… exist as a virulent pathogen causing fetal primary amoebic meningoencephalitis (PAM) in experimental animals and in humam. Inflammasomes are large intracellular multiprotein complexes that play a central role in innate immunity. They detect and respond to a large range of pathogen-associated …
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The effect of nfa1 accination against Naeglearia fowleri infection
… amoeba, Naegleria fowleri, causes fatal primary amoebic meningoencephalitis in experimental animals and in humans. The nfa1 gene that is cloned from N. fowleri is located on pseudopodia, especially amoebic food-cups and plays an important role in the pathogenesis of N. fowleri. In this …
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Characterization of an nf-actin gene in the pathogenic Naegleria fowleri
… as a virulent pathogen which causes fatal primary amoebic meningoencephalitis (PAM) in experimental animal or humans. The cytotoxicity of N. fowleri on target cells requires the contact-dependent mechanism such as a phagocytosis and the contact-independent mechanism such as a secretion of …