Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 225 for “"presynaptic"”.
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Presynaptic signalling in Huntington’s disease
… of BDNF signalling pathway regulate a form of presynaptic function called activity dependent endocytosis (ADBE) which is the dominant mode of endocytosis at the presynapse during high frequency stimulation. Previous work in this laboratory showed that ADBE is increased in primary cultured …
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Cytoskeletal Networks Driving Presynaptic Plasticity
… the field of synaptic plasticity by focusing on presynaptic terminals, which are equal partners with their postsynaptic counterparts. To date, the study of presynaptic plasticity has been difficult due to the limited number of presynaptic signaling molecules currently identified (particularly …
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Mechanisms Mediating Adaptive Presynaptic Muting Induction
… arrest excitatory neurotransmitter release from presynaptic terminals. The mechanisms responsible for inducing this presynaptic silencing: or "muting"), however, have been elusive. In order to elucidate the signals responsible, I used molecular techniques in defined networks of cultured neurons …
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Presynaptic spinal reflex modulation in children and adolescents
… (PAD), a GABAA dependent modality of presynaptic modulation of motor activity as partly responsible for these effects. PAD-mediated reflex modulation phenomena which are present in healthy children and adolescents have not been characterized. This thesis characterized how measures of …
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Spontaneous and evoked vesicle cycling at a presynaptic terminal
The presynaptic vesicle cycle is crucial for chemical neurotransmission. In response to an action potential, neurotransmitter-filled vesicles are exocytosed from the pre-synaptic terminal and activate specific receptors at the post-synaptic membrane. To sustain neuronal activity, vesicles are then …
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Mechanisms Of Presynaptic CaV2 Calcium Channel Localization In Caenorhabditis Elegans
… in the nervous system. Voltage changes in the presynaptic membrane are sensed by presynaptic voltage-gated calcium channels that mediate calcium influx at the nerve terminals to execute exocytosis of various kinds of neurotransmitters. Defects in presynaptic calcium channels lead to many …
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Study of Presynaptic Calcium Channels and a Novel Calcium Channel Calhm1
… processes. One process is synaptic targeting of presynaptic calcium channels. We have tested the hypothesis that synaptic targeting of presynaptic calcium channels depends on carboxy terminal interactions with mint and CASK proteins. To this end we have used mice mutant for P/Q-type calcium …
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Unmasking Impulsivity as a Glutamatergic Dysfunction Phenomenon: Presynaptic and Postsynaptic Considerations
… studies that aimed to examine glutamatergic presynaptic and postsynaptic neural substrates in key brain regions underlying motor impulsivity. Impulsivity is thought to be a function of a cortical imbalance that results in excessive “go” signaling (i.e. loss of inhibitory control). We …
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Deciphering molecular interactions in presynaptic dense projection formation in C. elegans
… which are chemical. Chemical synapses comprise a presynaptic neuron, which releases molecular messengers such as neurotransmitters, and a postsynaptic cell, which receives these messages and respond appropriately. To perform its specific role the presynapse utilises a distinct set of proteins at a …
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Oxysterols in Neurodegeneration and the Influence of Presynaptic α-Synuclein Phosphorylation
… a specific focus on alpha-synuclein (aSyn), a presynaptic protein centrally involved in PD pathology. Biophysical analyses revealed that both 24S-HC and 27-HC bind directly to aSyn with higher affinity than cholesterol. Interestingly, despite this binding, 27-HC does not alter the intrinsically …
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Molecular Mechanisms of Presynaptic Plasticity and Function in the Mammalian Brain
… the molecular mechanisms of different forms of presynaptic plasticity. Short-term facilitation increases neurotransmitter release in response to a high-frequency pair (paired-pulse facilitation; PPF) or train (train facilitation; TF) of presynaptic stimuli. Synaptotagmin 7 (Syt7) has been shown …
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Evaluation Of Presynaptic Dopamine Dynamics After: Toluene Inhalation Or Trkb Receptor Activation
… with exogenous BDNF and 7,8-DHF potentiated presynaptic DA release in BDNF+/- and wildtype mice respectively, with no effect on DA uptake. However, concentrations greater than 3 μM 7,8-DHF attenuated DA uptake rates in only BDNF+/− mice. In the presence of K252a, the BDNF or 7,8-DHF induced …
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Exploring a behavioral role for presynaptic inhibition at spinal sensory-motor synapses
… has left unresolved the contribution of presynaptic inhibition, if any, to motor behavior. Here we have used mouse genetics to gain access to the set of GABAergic interneurons that provide direct input to sensory terminals, and show that their activation evokes the defining physiological …
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INVESTIGATION OF ALPHA-SYNUCLEIN/TUBULIN INTERACTION IN PRESYNAPTIC MICROTUBULE DYNAMICS IN DOPAMINERGIC NEURONS
… plasticity. In pyramidal neurons, excitatory presynaptic sites are hotspots for MT nucleation, a process that regulates neurotransmission by providing the tracks for targeted bidirectional delivery of a rate-limiting supply of synaptic vesicles (SVs) to sites of stimulated release. Notably, …
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Coordination between presynaptic and postsynaptic properties measured at single terminals in hippocampal cultures
… strength at individual synapses: Intensity of presynaptic FM-staining was inversely correlated with AMPA current magnitude measured by local iontophoretic stimulation. I also found a negative correlation at individual puncta between FM-staining intensity and decay time of …
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The Role of Presynaptic Par-1 Kinase in Regulating the Localization of Active Zone Protein BRP
… or mitochondria. Further, imprecise levels of presynaptic Par-1 kinase disrupt the transport of Bruchpilot- an essential active zone scaffolding protein in Drosophila and leads to its accumulation of BRP in axons at the expense of BRP at active zones. Ultimately, the loss of BRP at active zones …
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Regulation of Presynaptic Ca²⁺ Channel Abundance at Active Zones Through a Balance of Delivery and Turnover
… trigger neurotransmitter release at specialized presynaptic sites termed active zones (AZs). The abundance of VGCCs at AZs regulates neurotransmitter release probability (Pᵣ), a key presynaptic determinant of synaptic strength. Although biosynthesis, delivery and recycling cooperate to establish …
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A Comparative Study of Sensory Neuron Synaptic Activity and the Role of Presynaptic Diversity, Specificity, and Regulation in Caenorhabitis Elegans
… we use pHluorin imaging (Vglut-pH) to monitor presynaptic glutamate release from single chemosensory neurons in intact animals and characterize the dynamics of endo- and exocytosis from two types of glutamatergic neurons, AWC<sup>ON</sup> and ASH. In Chapter 1, we describe the optimization of …
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CHARACTERIZATION OF THE ROLES OF MUSCLE-SYNTHESIZED BRAIN-DERIVED NEUROTROPHIC FACTOR AND PRESYNAPTIC TYROSINE RECEPTOR KINASE B IN MOTOR NEURON AXONAL TRANSPORT
… (p-TrkB), were assessed in the presynaptic and postsynaptic terminals of gastrocnemius-associated NMJs of mice missing muscle-derived BDNF. Further, the accumulation of TrkB, p-TrkB, dynactin, and JIP3 were evaluated following sciatic nerve ligations to assess the functionality …
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