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Showing 1 to 8 of 8 for “"prestin"”.
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Investigation of Prestin Membrane Topology by Substituted Cysteine Accessibility Method.
Prestin, an integral membrane motor protein in the outer hair cells of the inner ear, is proposed to be crucial for cochlear amplification. In support of this, in prestin knock out mice, there is a 40-60 dB loss of hearing sensitivity. Little is known about prestin’s structure-function …
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The Structure-Function Relationship of Prestin: from an Evolutionary Perspective
Prestin is the motor protein of cochlear outer hair cells. It belongs to a distinct anion transporter family called solute carrier protein 26A, or SLC26A. Members of this family serve two fundamentally distinct functions. While most members transport different anion substrates across a variety of …
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A study of the C-terminus in prestin by designing cleavable constructs
The membrane protein prestin plays a central role in the mammalian auditory system by enabling Outer Hair Cells (OHCs) in the cochlea to actively respond to electrical signals. Prestin belongs to the SLC26A family of membrane proteins, which all have a large cytosolic terminus containing a …
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Genomic Conservation of the Outer Hair Cell Motility Protein, Prestin in the Monotreme: Ornithorhyncus anatinus (Platypus)
… process that is thought to be unique to mammals. Prestin, the motor protein of these OHCs, is crucial for its function in mammals. Loss of prestin has been found to result in a high-frequency hearing loss of 40 to 60 dB (sensitivity) in mice (Liberman et ai, 2002). Since being isolated in gerbil …
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Structural Characterization of the C-terminus of the Cochlear Motor Protein Prestin: Intrinsic Disorder Linked to Voltage Sensor Function
… support this function. The motor protein called prestin resides in the lateral wall of the OHCs. Prestin undergoes voltage-dependent conformational changes, which correlates to the movement of charge through the membrane or non-linear capacitance (NLC). This property underlies OHC …
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Developmental Alterations in the Distribution of Specific Lateral Wall Proteins Modify Outer Hair Cell Mechanical Properties
… of a plasma membrane, in which the motor protein prestin is densely packed, an actin-spectrin cortical lattice and subsurface cisternae. Developmental alterations in protein distribution and localization of each of these structures were correlated with alterations in OHC compliance to assess their …
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A feedback analysis of outer hair cell dynamics
… which results in contraction. The motor protein prestin is driven by receptor potentials. However, low-pass filtering by the plasma membrane should severely attenuate the receptor potential at high frequencies (> 100 kHz) where mammalian hearing has been observed. Thus, an open question is how …
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Defined populations of inner ear progenitor cells show limited and distinct capacities for differentiation into hair cells, neurons, and glia
… cells expressed the outer-hair-cell protein, prestin, while only vestibular derived cells expressed the vestibular extracellular matrix marker, otopetrin. Since Atohi expression is consistently found in new hair cells, we used an Atohl-nGFP mouse line to identify hair cell candidates. We find …