Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"presomitic mesoderm"”.
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The role of pax genes in vertebrate segmentation
… in particular are associated with the paraxial mesoderm, especially the development of the myogenic lineage. However, recent studies have suggested that Pax3 and Pax7 may have earlier, morphogenetic roles in the segementation of the paraxial mesoderm. Here we examine the expression of Pax3 and …
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Molecular and biochemical characterisation of phosphorylation-dependent NICD1 turnover: novel roles for CDK1 and CDK2
… pinched off from the anterior end of the presomitic mesoderm (PSM). The rhythmicity of somitogenesis is regulated by a molecular clock called the segmentation clock that drives the periodic expression of a number of “clock” genes in the PSM, with a periodicity that matches somite …
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Analysis of the Zebrafish Segmentation Clock
… from an unsegmented tissue called the presomitic mesoderm (PSM) by a process called somitogenesis. <br></br><br></br> Underlying the periodicity of somitogenesis are transcriptional oscillations of cyclic genes in the cells of the PSM. On a tissue level, these oscillations manifest as …
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Identifying the Origin of Zebrafish (Danio rerio) Renal Progenitor Cells
… for RPCs. Here, genetic lineage labeling of the presomitic mesoderm was performed and showed that mesonephric tubules contain the lineage label, supporting a conclusion whereby RPCs are derived from somitic mesoderm. This finding represented a fundamental shift in our understanding of renal …
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Notochord morphogenesis as a mechanical driver of embryo axis elongation
… somites in the segmented region of the axis and presomitic mesoderm in the posterior. Therefore, it is appropriately positioned to play a role in mechanically elongating the somitic compartment. In this PhD thesis I characterise axis elongation and notochord morphogenesis in the developing …
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Pattern Formation During Extensive Cell Movements
… examine the robustness of patterning within the presomitic mesoderm, where a posterior to anterior pattern of gene expression is observed despite high levels of cell rearrangement. Within this tissue, the pattern is observed to accurately scale to the shortening anterior to posterior length and …
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Investigating the role of cell cycle regulators in mesoderm specification
Mesoderm is one of the three primary germ layers from which the cardiovascular system, muscle and bone originate and derivatives of the mesoderm lineage are affected in a number of pathologies. Therefore, understanding the mechanisms regulating formation of mesoderm is interesting for a diversity …
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The roles of T and Tbx6 during gastrulation and determination of left/right asymmetry
… to find genes that govern the establishment of presomitic mesoderm identity. Tbx6 homozygous mutant embryos were used to investigate how Tbx6 affects multiple processes in the establishment of left-right asymmetry, which include node and node cilia development and the expression of genes …
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The mechanical characteristics and differentiation potential of the axial progenitor region in vertebrate embryos
… zone (PZ) and contains neural tube (NT) and presomitic mesoderm (PSM) progenitors, as well as a bi-potent population of cells that contributes to both: the Neuro-Mesodermal Competent cells (NMCs). The NMC region is defined by the co-expression of the transcription factors Sox2 and …
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A genetic analysis of somitogenesis in the Medaka (Oryzias latipes)
… that are generated in a rhythmic manner from the presomitic mesoderm (PSM) in the embryonic tailbud. Later, they differentiate into skeletal muscle, cartilage and dermis. Somitogenesis is regulated by a complex interplay of different pathways. Notch/Delta signaling is one of the pathways well …
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The evolution of somitogenesis: Mechanisms of paraxial mesoderm elongation in zebrafish and other vertebrates
… elongation and segmentation of the paraxial mesoderm to form somites. Although the segmentation aspect of this has been widely studied, the elongation aspect is not well understood. Posterior growth is widely assumed to be the main driver, but there is very little evidence for this – …