Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"presenilin mutations"”.
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Genetic dissection of variability in cognitive and locomotor phenotypes using Drosophila melanogaster
… seen in learning, memory, and neurodegenerative mutations using the Drosophila Synthetic Population Resource (DSPR). I utilized quantitative trait loci (QTL) mapping and directional selection methods to identify genomic regions contributing to olfactory learning and memory using an appetitive …
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Modeling Alzheimer's Disease Using CRISPR/CAS9 Gene Editing and Induced Pluripotent Stem Cells Reveals Conserved Cellular Mechanisms
… dominant familial AD (fAD) result from genetic mutations in three key genes: amyloid precursor protein (APP), and two APP processing-related genes (presenilin-1 (PSEN1), and presenilin-2 (PSEN2)), supporting the theory that altered APP metabolism is a central cause of AD. However, which product …