Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 19 of 19 for “"prescribed drugs"”.
-
An investigation into the role of acetylation and ligand-dependent nuclear localisation in glucocorticoid receptor transcriptional regulation
… responses, is a target of many therapeutically prescribed drugs. The GR undergoes multiple post-translational modifications, including phosphorylation and acetylation; however the role of GR acetylation in transactivation is unclear.
-
Adolescent Involvement in Alcohol and Drug Use
… and organic materials that can be labelled drugs. Such materials would include alcohol, tobacco, cannabis, amphetamines, barbiturates, cocaine, the opiates and also the hundreds of medicines to be found in chemist shops. Our society is a drug taking society, that is a pill for every ill. …
-
EFFECTS OF ALCOHOL AND ACAMPROSATE, AN ALCOHOL USE DISORDER TREATMENT, ON NONHUMAN PRIMATE BEHAVIOR AND MEMORY
… posterior parietal cortex and others. Many drugs are used in the treatment of AUD, with acamprosate being one of the most commonly prescribed drugs. The specific mechanism of acamprosate has not been identified, but it is thought to have an indirect effect on mGluR, NMDA, and possibly GABAA …
-
Acute Confusional State in Elderly Patients with Hip Fracture. Identification of risk factors and intervention using a prehospital and perioperative management program
… (SPMSQ) score <8 correct answers’, ‘prescribed drugs ≥4’, ‘hemoglobin <100 g/L’, ‘creatinine >100 micromol/L’, ‘dependency in living’, ‘unable to walk alone’, and ‘fracture other than undisplaced intracapsular’. In paper II significant perioperative risk factors for a poorer recovery …
-
Selective Targeting of CYP3A5 Through Chemical and Genetic Approaches
… metabolize greater than half of all currently prescribed drugs. These promiscuous enzymes can bind a broad and structurally diverse array of compounds, in turn leading to an increased risk of their modulation via small molecules. In the case of CYP3A5, which is over-expressed in some cancers, …
-
Back and neck pain: Patterns in healthcare consultations
… linked with national registers on sick leave, prescribed drugs, and socioeconomic status. Additionally, the thesis include a comparative study between data from the Skåne Healthcare Register with that of an United Kingdom (UK) consultation database. he main variables under study are in Paper …
-
The Role of B-Arrestin in Agonish-Induced Down-Regulation of the M1 mAChR
… are currently the target for 50% of all prescribed drugs. Cells utilize these receptors to transduce extracellular stimuli across the plasma membrane and activate intracellular G proteins, which then initiate second messenger system cascades. GPCR signaling is the focus of much research. …
-
The Role of B-Arrestin in Agonish-Induced Down-Regulation of the M1 mAChR
… are currently the target for 50% of all prescribed drugs. Cells utilize these receptors to transduce extracellular stimuli across the plasma membrane and activate intracellular G proteins, which then initiate second messenger system cascades. GPCR signaling is the focus of much research. …
-
Benzodiazepine and opioid dependence. Clinical and meta-analytical studies.
… rate study (Paper II) the frequency of prescribed drug dependence among 130 alcohol dependent patients in open care, 23 long-term institutionalized alcoholics, and 120 healthy controls were analysed. Alcoholics were more often dependent on total prescribed drugs, BZD and zopiclone than …
-
EFFECTS OF CHRONIC METHYLPHENIDATE ON DOPAMINE/SEROTONIN INTERACTIONS IN THE MESOLIMBIC DOPAMINE SYSTEM OF THE MOUSE
Methylphenidate (MPH) is one of the most commonly prescribed drugs in the United States. MPH is a psychostimulant that inhibits the dopamine (DA) and norepinephrine (NE) transporters to increase extracellular monoamines. Abuse rates of MPH are increasing as prescription rates increase, but the …
-
Human Genetics, Psychotropic Drugs, and Acts of Violence
… that the pharmacological properties of the prescribed drugs or the interaction between the drugs and the enzymes that are primarily responsible for their metabolism (cytochrome P450s) could cause these reactions. Given that acts of violence could be medication-induced, the role of the rate …
-
INAPPROPRIATE ANTICHOLINERGIC MEDICATION USE IN ELDERLY PATIENTS
… of dementia. The inappropriate anticholinergic drugs were identified using revised 2012 American Geriatrics Society (AGS) Beers criteria. Weighted descriptive statistics were used to estimate the prevalence of inappropriate anticholinergic medication use in the elderly and elderly dementia …
-
A retrospective evaluation on the use of Cephalosporins in open-heart surgery
… "Antibiotics are among the most frequently prescribed drugs in this country exceeded only by the psychoactive drugs." Dr. Charles C. Edwards, former Commissioner of the Food and Drug Administration, recognized that a problem existed and recommended the establishment of a National Task Force …
-
IN VITRO AND IN VIVO KINETIC MODELING OF DIAZEPAM METABOLISM
… the metabolism of more than 60% of the top 200 prescribed drugs. X-ray and NMR data of CYP enzyme suggest that relatively large and flexible active sites are capable of multi-substrate binding. Due to the multiple substrate-binding, CYP reactions tend to show non-Michaelis Menten kinetics …
-
New Synthetic Polyamines as Multi-Target-Directed Ligands for the Treatment of Alzheimer's Disease and Cancer: Design, Synthesis and Biological Evaluation
… pathology. In particular in AD, most currently prescribed drugs aim to increase the level of acetylcholine in the brain by inhibiting the enzyme acetylcholinesterase (AChE). However, clinical experience shows that AChE inhibition is a palliative treatment, and the simple modulation of a single …
-
Investigating Transcription Factor Networks That Drive Biological Clocks and Oscillators
… more than half of the most frequently prescribed drugs in human</p><p>patients target an effector whose expression is under circadian control. Given the large</p><p>proportion of genes that are periodically expressed across different biological processes,</p><p>it is critically …
-
Omics-driven and constraint-based modelling of microbial community metabolism
… Shannon-diversity index, and total number of prescribed drugs. Finally, I conclude by highlighting further applications of metaGEM and detailing possible future directions for omics-driven metabolic modelling, including studying the global microbiome plastic-degrading potential, long read …
-
Renal Drug Transporters – Clinical Significance and Role in Drug-Drug Interactions
… and often work in tandem to secrete therapeutic drugs and their metabolites into tubular lumen. Furthermore, transporter-mediated drug-drug interactions (DDIs) have become a significant clinical concern as they can adversely impact drug disposition, efficacy, and toxicity. The overall goal of my …
-
Relationship Between Angiotensin Receptor Blockers and Cancer: A Nested Retrospective Longitudinal Cohort Study
… receptor blockers (ARBs) are commonly prescribed drugs that have proven benefits among patients with cardiovascular and diabetic diseases. Recently a concern of modest increase in the risk of solid cancers among ARB users was reported. This became controversial, as many experts argued …