Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"prenyltransferase"”.
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Modifying Tryptophan and Indole-Derived Compounds Using Engineered Indole Prenyltransferase Enzymes
<p>Indole Prenyltransferase (IPT) enzymes are present in many microorganisms. They catalyze the transfer of prenyl moieties from natural pyrophosphate donors to tryptophan and other indole-derived small molecules. Prenylation alters the structure of small molecules, enhances their hydrophobicity, …
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Altering the Regiospecificity of C6 Indole Prenyltransferase Enzymes Towards Drug Development
<p>Prenyltransferase (PT) biocatalysts are late-stage tailoring enzymes that modify natural products. PTs catalyze the attachment of prenyl moieties to natural product acceptors using pyrophosphate donors. This prenyl modification in small molecules leads to changes in structural and biological …
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Characterization Of Protein Prenyltransferases And Protein Prenylation In Plasmodium Falciparum
… lipid modification by a prenyl group. Protein prenyltransferases, which catalyze the post-translational prenyl modification, have been established as a target for anticancer therapy. Research done in our laboratory has demonstrated recently that prenyl modification of proteins could be a novel …
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Synthesis of Novel Isoprenoid Diphosphate Analogs as Chemical Tools to Investigate Protein Geranylgeranylation
… B, and the kinesin motor proteins CENP-E and F. Prenyltransferase (PTase) inhibition is currently being explored as a possible treatment not only for cancer but for a wide variety of other diseases.</p> <p>Clinical studies revealed that the effectiveness of farnesyltransferase inhibitors (FTIs) …
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The Role of High-Density Lipoproteins and Related Pathways in Alzheimer’s Disease
… clearance of brain amyloid to plasma. Finally, prenyltransferase-deficient mice were used to investigate the role of protein prenylation in synaptic function. Prenylation is an important posttranslational lipid modification process that attaches isoprenoids (the intermediates in the cholesterol …
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REDEFINING THE SCOPE OF PRENYLATION: DISCOVERY OF “FORBIDDEN” SUBSTRATE RECOGNITION AND DEVELOPMENT OF METHODS UTILIZING PRENYLATED PROTEINS
… the biological relevance of this new class of prenyltransferase substrates in cells, and supports future investigation of the impact of these non-canonical prenylated proteins on cell behavior and biological function.</p> <p>With the discovery of new -C(x)3X recognition motifs in prenylation, …
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Biosynthesis and medicinal chemistry of therapeutically promising plant natural products
… identified and characterized a novel flavonoid prenyltransferase and O-methyltransferase from the medicinal herb Epimedium sagittatum that is known to produce many bioactive prenylated and methylated flavonoids.
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Pathogen-Specific Adaptations to Conserved Signaling Pathways in Cryptococcus neoformans
… and infection models, I demonstrated that the prenyltransferase, geranylgeranyl transferase I (GGTase I) is required for thermotolerance and pathogenesis. Using fluorescence microscopy, I found that only a subset of conserved GGTase I substrates requires this enzyme for membrane localization. …
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Targeting isoprenoid and quinone biosynthesis for antimicrobial discovery
… menaquinone decarboxylase that is dependent on a prenyltransferase enzyme, UbiX. UbiD family of enzymes are reported in literature as phenolic acid decarboxylase and ubiquinone decarboxylase. We report the first UbiD functioning as menaquinone decarboxylase in futalosine pathway, active with …
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Mechanistic investigations on polyprenyl transferases and multi-target antibiotic discovery
Terpenoid biosynthesis plays essential structural and functional roles in almost all life forms. Prenyl transferases, enzymes involved in the isoprenoid metabolism related to prenyl chains, transfer allylic prenyl groups to acceptor molecules. Head-to-tail condensations, usually of allylic …