Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"prenatal testing"”.
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Patient Perception of Negative Non-Invasive Prenatal Testing Results
<p>Non-invasive prenatal testing (NIPT) uses cell-free fetal DNA to assess for fetal aneuploidy during pregnancy. NIPT has higher detection rates and positive predictive values than previous methods; however, NIPT is not diagnostic. Studies suggest patients may underestimate the limitations of …
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Understandings of Down's syndrome and their place in the prenatal testing context
… is a growing consensus that decisions about prenatal testing should a) be informed, and b) reflect the individual's attitudes and values. Most research has focused on information and attitudes in relation to the tests but there has been little attention given to these factors in relation to …
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Prenatal Testing Decisions and Motivations In Pregnancies Conceived Via In Vitro Fertilization
… fertilization (IVF) and preimplantation genetic testing for aneuploidy (PGT-A) impact the decisions individuals make about prenatal genetic testing. This quantitative study aimed to examine the prenatal testing decisions made by pregnant individuals who conceived via IVF as well as to compare the …
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Rhetoric, Disability, and Prenatal Testing: Down Syndrome as an Object of Discourse
… another. In particular, this project examines prenatal testing for Down syndrome as a rhetorical situation that initiates and circulates many different discourses about Down syndrome. Chapter One begins by examining a frequently cited statistic in critiques of prenatal testing—the estimated …
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Anchoring and Uptake of Non-Invasive Prenatal Testing In The First and Second Trimester
<p>Non-invasive prenatal testing (NIPT) is a highly sensitive and specific screen for common aneuploidies that eliminates the risk of miscarriage that diagnostic tests carry. It is unclear how this new prenatal option will impact pregnant women’s decision making process. Women undergoing genetic …
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Current Genetic Counseling Practice Following Positive Non-Invasive Prenatal Testing For Sex Chromosome Abnormalities
… purpose of this study was to describe current prenatal and pediatric genetic counseling practice following a non-invasive prenatal testing (NIPT) result positive for a sex chromosome abnormality (SCA). The positive predictive value for SCA with NIPT is lower than seen for Trisomy 21 due to …
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Exploring The Potential Yield of Prenatal Testing By Evaluating A Postnatal Population With Structural Abnormalities
… pregnant women are offered a host of different testing options to identify a possible genetic cause for the structural abnormality(ies). When considering what type of test to undertake, there is limited information on the diagnostic yield of the varying testing options. Some women may miss an …
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Attitudes to ward and Utilization of Non-Invasive Prenatal Testing For Chromosome Aneuploidy Among Ob/Gyns
<p>Prenatal diagnosis is traditionally made via invasive procedures such as amniocentesis and chorionic villus sampling (CVS). However, both procedures carry a risk of complications, including miscarriage. Many groups have spent years searching for a way to diagnose a chromosome aneuploidy without …
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Cell-free fetal DNA (cffDNA) enrichment for non-invasive prenatal testing (NIPT): a comparison of molecular techniques
Prenatal assessment of fetal health is routinely offered throughout pregnancy to ensure that the most effective management can be provided to maintain fetal and maternal well-being. Currently, invasive testing is used for definitive diagnosis of fetal aneuploidy, which is associated with a 1% risk …
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Genetic Counselors' Experiences With and Approaches to Discordant Genotypic and Phenotypic Sex Detected Via Non-Invasive Prenatal Testing
<p>As the use of non-invasive prenatal testing becomes more ubiquitous during pregnancy, genetic counselors (GCs) will see clients more frequently for discordant sex identification via non-invasive prenatal testing (NIPT-DSI). Thus, it is imperative to investigate what GCs consider important when …
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"As Long as It's Healthy...": Prenatal Health, Disability and Biopower
… thirty years have seen widespread adoption of prenatal testing technologies used to detect potential disabilities in fetuses (Lupton, 2011; Rapp, 2011; Tremain, 2006; Weir, 1996). The increased routinization of prenatal testing and the discourse of responsible motherhood coupled with discourses …
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The influence of Down syndrome related information on attitudes toward selective reproduction
… persons with DS were related to decisions about prenatal screening. For decisions about prenatal testing and selective abortion, though, perceptions of parenting a child with DS mediated the relationship between attitudes and reproductive intentions. These findings suggest that women may be more …
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An investigation into the reasons for non-uptake of carrier testing in a family affected by alpha thalassaemia X-linked mental retardation (ATR-X) syndrome
… of the mutation in this family, carrier and prenatal testing is available. However, since the announcement in 2007 that testing is available, no individuals have presented themselves for their carrier status to be determined. The aim of this study was to investigate the reasons why females in …
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Impact of prenatal screening on future resource utilization in pregnancy
… Gynaecologists of Canada first recommended that prenatal screening for fetal aneuploidy be offered to all pregnant women. This is an important change in clinical obstetrics as previously these services had only been routinely offered to women who would be 35 or older at the time of delivery; …
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Nipt Results Indicative of Maternal Neoplasms: Genetic Counselors' Preferences and Attitudes
<p>Performing non-invasive prenatal testing (NIPT) on a pregnant woman with a chromosomally abnormal neoplasm may incidentally lead to the diagnosis of cancer due to the coexistence of circulating tumor and placental DNA. Published information regarding NIPT’s accuracy for neoplasm screening is …
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Qualify Microplate Reader’s Specification and Establish the Acceptance Criteria for Modified PicoGreen Kit in Measuring cell-free DNA Concentration in Clinical Laboratory
… in IVD (in-vitro diagnostics) are non-invasive prenatal testing, circulating tumor DNA markers, transplant rejection using donor derived cfDNA and microbial cfDNA in identifying infectious agents (3,4,5,6). The current challenge in our laboratory is to measure cfDNA concentration from minimal …
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Attitudes toward prenatal diagnosis and termination of pregnancy in Saudi Arabia
… will soon make it possible to offer parents prenatal testing for a large number of different genetic disorders. The tests that have been offered to date are available because of technology, not because of the burden or prevalence of the condition. Parents' attitudes to different genetic …
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Support Desired By Women Following Termination of Pregnancy For A Fetal Anomaly
<p>With the rapidly evolving field of prenatal testing, there is a growing need to provide support for women pursuing a termination of pregnancy following the discovery of a fetal anomaly. Previous studies have documented that women in this situation often feel unsupported after the procedure, but …
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Obstetrician and Gynecologist Utilization of The Nipt Expanded Testing Option
<p>Noninvasive prenatal testing (NIPT) enables the detection of common fetal aneuploidies such as trisomy 21, trisomy 18, trisomy 13, and sex chromosome abnormalities via analysis of cell-free fetal DNA circulating in maternal serum. Although the accuracy of NIPT for fetal aneuploidy is expected to …
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Patient Understanding of Fetal Sex Versus Gender in the Context of Routine Cell-Free DNA Screening
<p>Non-invasive prenatal testing (NIPT) is the current standard of care to screen for fetal aneuploidy using cell-free DNA (cfDNA). NIPT screens for sex chromosome aneuploidies (SCAs) and in doing so, can predict fetal chromosomal sex. Despite sex and gender being distinct concepts, many patients …
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