Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"prenatal development"”.
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Disinfection by-products and prenatal development
… risk estimation for studies of DBPs and prenatal development. These approaches are described below. Past epidemiological studies of DBPs and birth outcomes have used exposure measurements for study participants that are susceptible to misclassification due in part to intra-system spatial …
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Developmental, ecological and biological drivers of macroevolutionary trajectories of postcranial morphological diversification in bats
… properties of the wing, as well as the developmental, ecological and biological drivers of such disparity by: 1) identifying the prenatal developmental trajectories of postcranial ossification sequence and growth, 2) quantifying differences in allometric trajectories of postcranial …
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An epigenetic theory of hemispheric specialization: the role of prenatal sensori-motor experience in the development of turning bias and spatial orientation in bobwhite quail (Colinus virginianus)
This study examined the effects of prenatal sensory and motor experience on the development of spatial orientation and turning bias in bobwhite quail. The theory presented here describes hemispheric specialization as the result of probabilistic events in the developing organism's prenatal …
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Translational defects in multiple tissues from the Smn2B/- mouse model of SMA.
… with ribosomes/polysomes during postnatal development, indicating dynamic SMN function in protein translation during post-natal development. In SMA condition, where SMN protein levels drop, this binding reveals a tissue-specific decrease in the spinal cord and liver. Through ribosome …
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Glycine receptors in the developing rat spinal cord
Inhibitory glycine receptors (GlyRs) undergo developmental regulation with α2 subunits most abundant at prenatal and early postnatal stages, and α1 subunits predominating in adults. In comparing the relative amounts of mRNA for two known splice variants of the α2 subunit, α2A and α2b, in the rat …
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Prenatal exposure to maternal obesity and SFLT-1 overexpression and cardiovascular function in the adult offspring
… cardiovascular diseases; however, the effects of prenatal development cannot be overlooked. In the 1980s Barker proposed a hypothesis that poor nutrition in the fetal or early neonatal period increases susceptibility to the negative effects of an affluent diet during adulthood. Overall, there is …
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Imprinted Gene Expression and Phenotype of Bovine Concepti with Bos taurus and Bos indicus Genetics
… dependent manner, are critical regulators of prenatal development. Altered epigenetic modifications of imprinted genes in response to maternal environmental stimuli are believed to impact on prenatal development with long-term consequences for postnatal phenotype, a process which is known as …
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Prenatal SMN-dependent defects in translation uncover reversible primary cilia phenotypes in a mouse model of spinal muscular atrophy
… The SMN protein is dynamically regulated during development, where high levels of SMN expression during embryogenesis undergo a significant reduction after birth, suggesting an important role for SMN prenatally. SMN has also been shown to be a ribosome-associated protein that plays a crucial role …
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An integrative analysis of the multi- and transgenerational effects of endocrine-disrupting chemicals on behavior and neurobiology
… to EDCs during hormone-sensitive periods of prenatal development can result in disease and dysfunction later in life. Furthermore, EDC effects have been reported in individuals several generations removed from the initial exposure. In this dissertation, I investigated the effects of …
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Dissecting the spatio-temporal development of the human reproductive tract
… due to the systemic effect of sex hormones. Its development depends on tightly regulated processes of sex differentiation, spatial patterning, and morphogenesis, which, when disrupted, can lead to congenital alterations and long-term reproductive disorders. In this thesis, I generated the first …
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Essays in applied microeconomics: Public policies and their impacts on health
… matter 2.5 (PM 2.5) on fetal health during prenatal development and its implications for infant health and in vitro fertilization (IVF). Using an instrumental variable approach exploiting the regulatory changes introduced by the Clean Air Act (CAA) in 2004 for PM 2.5 control, I find that a …
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Single-cell Protein-Transcriptome Atlas of Haematopoiesis across the Human Lifespan
… tissues representing various stages of human development. By taking advantage of a custom panel of 198 oligo conjugated antibodies, we successfully profiled over 250,000 cells collected from tissues representing prenatal development (including yolk sac, embryonic and fetal liver, and bone …
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Epidermoid tumours of the pituitary body, a clinical and pathological study: written for the Syme Fellowship, 1933
… of any such structure at any stage of the human prenatal development. The term adamantinoma introduced by Onanoff is one which has become quite filled in the terminology. It was based on a mere structural resemblance of these tumours to the developing enamel organ - a resemblance which is a very …
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Exploring the Soft Tissue of the Archosaurian Feeding System through Evolutionary and Developmental Temporal Space
… As useful as teeth are, we can see the repeated development of edentulous (=toothless) system throughout the fossil record, most frequently in Archosauria. Archosauria, represented today by living crocodylians and birds and includes extinct non-avian dinosaurs and pseudosuchians, first appeared …