Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"premalignancy"”.
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Genomic and Transcriptomic Landscape of Colorectal Premalignancy
… strategies. The challenge in characterizing premalignancy has always been the limited availability of sample material. This challenge is tackled by getting more samples, integrating public datasets, deploying better technology that use less amount of nucleic acids and in-silico tools to …
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Differential progression of pancreatic premalignancy in geographically distant murine transgenic cohorts uncovers key role of microbial metabolites
… significantly different rates of pancreatic premalignancy despite possessing a shared lineage. After ruling out potential differences in food and water sources as well as handling protocols, we examined composition of the gut microbiomes in both cohorts. These analyses revealed that in …
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Computational Genomic Models For Spatio-Temporal Investigation of Early Lung Cancer Pathology
… occur in normal tissues, preceding identifiable premalignancy-associated morphological changes. We sought to comprehensively survey the somatic mutational architecture of the normal airway in early-stage NSCLCs. Targeted DNA sequencing allowed us to capture driver mutations at low cellular …
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Exploring the adaptive immune response to Oncogene-Induced-Senescence
Clinical studies have shown that chronic liver disease, a major risk factor for hepatocellular carcinoma (HCC), is associated with the accumulation of senescent cells within the liver. Senescence is an acutely tumour-suppressive, but chronically pro-tumorigenic stress-responsive cell pathway. …