Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"prelimbic cortex"”.
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Adenosine monophosphate-activated protein kinase regulates reward regions of the brain during cocaine sensitization
… dorsal striatum and increased in the prefrontal cortex, though only broad brain regions were investigated. Subregions of the prefrontal cortex, the prelimbic and infralimbic cortices, differentially regulate reward signaling. For example, the prelimbic cortex is known to be necessary for …
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Computational models of neuronal fear and addiction circuits
… critical element of the fear circuit, the prelimbic cortex and linked it with a model of the basal amygdala, to investigate how these two structures worked together to modulate fear expression. Since malfunction in the fear circuit is thought to underlie the pathology of post traumatic …
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Investigating prefrontal cortex neuronal signatures of opioid-induced risk-taking behavior
… of risky opioid seeking in the prefrontal cortex, a region implicated in executive decision-making. Following morphine conditioned place preference, rats underwent a conflict test in which fear-inducing cat odor was introduced in the previously drug-paired side of the apparatus. While the …
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Mapping the neural circuits that underlie metabolic vs. emotional regulation of food-seeking behavior
… from projection-defined neurons in the prelimbic cortex (PL), an input source of aPVT<sup>CRF</sup> neurons, and chemogenetic manipulations of distinct PL circuits, we found that divergent PL projections to the PVT or the NAc mediate either hedonic feeding during satiation or feeding …
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Role of serotonin2C receptor (5-HT2CR) in expression of cocaine-induced conditioned hyperactivity
… following microinjection of MK212 into the prelimbic cortex (PrL), a subarea of the medial prefrontal cortex (mPFC). We found that MK 212 at 0.15 ìg/0.2ìl/site inhibited expression of cocaine-induced conditioned hyperactivity while not affecting basal activity. Since activation of the …
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Neurochemical and Neuroanatomical Basis Of Reversal Learning In The Rat
… focusing on the lateral and medial orbitofrontal cortex, as well as regions of the medial prefrontal cortex. Local temporary inactivation of these structures via infusion of a muscimol/baclofen mixture produced dissociable effects. Inactivation of the infralimbic cortex led to a significant …
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Age-dependent effects of chronic amphetamine on prelimbic-nucleus accumbens circuit function and goal-directed behavior
… (HFS)-induced long-term depression (LTD) in the prelimbic cortex (PL) is likely to be a target influenced by repeated AMPH in an age-of-exposure dependent manner, which results in abnormalities in the reward circuit function and goal-directed behavior. Using a rat model, this hypothesis was …
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Role of prefrontal cortex and cholinergic modulation in attentional performance in rats
… thesis investigates the role of the prefrontal cortex and cholinergic modulation in attentional performance, and to a lesser extent, inhibitory response control, in rats. A greater understanding of these functions is important for the effective treatment of attentional and impulsive control …
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Brain substrates of behavioural endophenotypes predictive of compulsive drug-seeking
… lower grey matter volume in the infralimbic cortex and ventral striatum. Functionally, compulsivity and stickiness were predicted by decreased connectivity between the prelimbic cortex and the anterior cingulate cortex with the posterior dorsomedial striatum. In summary, this thesis supports …
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Neural Plasticity in the Amygdala Across the Development of an Incentive Cocaine Seeking Habit
… changes in activity in areas of the prefrontal cortex (PFC) from which it receives inputs, namely the orbitofrontal cortex, the prelimbic cortex, and the infralimbic cortex. Using the immediate early gene cFos as a marker of cellular activity, I performed RNAscope on brain sections encompassing …