Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 20 for “"prelimbic"”.
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Age-dependent effects of chronic amphetamine on prelimbic-nucleus accumbens circuit function and goal-directed behavior
… (HFS)-induced long-term depression (LTD) in the prelimbic cortex (PL) is likely to be a target influenced by repeated AMPH in an age-of-exposure dependent manner, which results in abnormalities in the reward circuit function and goal-directed behavior. Using a rat model, this hypothesis was …
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Adenosine monophosphate-activated protein kinase regulates reward regions of the brain during cocaine sensitization
… Subregions of the prefrontal cortex, the prelimbic and infralimbic cortices, differentially regulate reward signaling. For example, the prelimbic cortex is known to be necessary for establishing cocaine sensitization while the infralimbic cortex is not. AMPK’s role in cocaine sensitization …
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Heterologous Expression of Alpha 6*- Nicotinic Acetylcholine Receptors and the Natural Distribution of Alpha 6 Subunits
… cingulate, entorhinal, perirhinal, piriform, and prelimbic cortices. nAChR α6 mRNA was coexpressed with GAD in the amygdala, dentate gyrus, striatum, SN, VTA and cingulate, entorhinal, prelimbic and prelimbic cortices. TH was exclusively co-localized with nAChR α6 mRNA in the SN and VTA. Findings …
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Adversity in early adolescence alters female rats' anxiety-related behaviours and serotonergic innervation profiles in adulthood
… of the mPFC, but not in the cingulate or prelimbic (PL) subregions. IPS in early adolescence did not affect serotonergic innervation profiles in any sub-fields of the ventral hippocampus. The findings confirm and extend on earlier evidence that stress during early adolescence promotes the …
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Computational models of neuronal fear and addiction circuits
… critical element of the fear circuit, the prelimbic cortex and linked it with a model of the basal amygdala, to investigate how these two structures worked together to modulate fear expression. Since malfunction in the fear circuit is thought to underlie the pathology of post traumatic …
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An Examination of Hippocampal and Prefrontal Contributions to Spatial Learning and Memory using Immediate Early Gene Imaging
… plasticity, and activation in CA3, prelimbic and anterior cingulate cortices was strongly associated with flexible spatial memory recall (i.e. pattern completion). Finally, we revealed that spatial memory deficits induced by NMDA receptor blockade could be partially prevented by …
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The connectivity of the mammalian prefrontal cortex
… injected (20 -100 nl) into subdivisions of PFC (prelimbic, infralimbic, medial-orbital, ventral-orbital, ventrolateral-orbital, lateral-orbital and dorsolateral-orbital) and their projections studied. Tracer studies identified clear evidence of significantly ordered projections from PFC to …
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Investigating prefrontal cortex neuronal signatures of opioid-induced risk-taking behavior
… Risk-Avoiders). Single-unit recordings from the prelimbic cortex (PL) demonstrated decreased neuronal activity upon acute morphine exposure in both Risk-Takers and Risk-Avoiders, but this firing rate suppression was absent after repeated morphine administration. Risk-Avoiders also displayed …
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Mapping the neural circuits that underlie metabolic vs. emotional regulation of food-seeking behavior
… from projection-defined neurons in the prelimbic cortex (PL), an input source of aPVT<sup>CRF</sup> neurons, and chemogenetic manipulations of distinct PL circuits, we found that divergent PL projections to the PVT or the NAc mediate either hedonic feeding during satiation or feeding …
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Mediodorsal thalamus contributes to the timing of instrumental actions
… of neurons predominantly innervating the prelimbic (PL) cortex, an area with well-established as important for interval timing behavior. </p><p>The experiments conducted here provide substantial evidence for MD involvement in timing durations over multiple seconds, with pharmacological …
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Role of serotonin2C receptor (5-HT2CR) in expression of cocaine-induced conditioned hyperactivity
… following microinjection of MK212 into the prelimbic cortex (PrL), a subarea of the medial prefrontal cortex (mPFC). We found that MK 212 at 0.15 ìg/0.2ìl/site inhibited expression of cocaine-induced conditioned hyperactivity while not affecting basal activity. Since activation of the …
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Neurochemical and Neuroanatomical Basis Of Reversal Learning In The Rat
… and omissions during perseveration, whereas prelimbic cortex inactivation had no major effects. The findings of the thesis are discussed in terms of the separate roles for the different phases of reversal learning of different sectors of the frontal lobe and striatum in the rat, and the …
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Role of prefrontal cortex and cholinergic modulation in attentional performance in rats
… on attentional performance, in which the prelimbic cortex (PL) appears to play a role in rCPT performance, compared with a role of the anterior cingulate cortex (ACC) in 5-CSRTT performance; and 3. a role of ascending cholinergic projections from the basal forebrain to the ACC in 5-CSRTT …
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Generation and tuning of learned sensorimotor behavior by multiple neural circuit architectures
… shift is reversed by optogenetic stimulation of prelimbic input to striatum, pinpointing a circuit element which may control stress-induced behavioral changes. Furthermore, a circuit hypothesis is presented to explain why sensitivity to changing reward values diminishes with overtraining.
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Brain substrates of behavioural endophenotypes predictive of compulsive drug-seeking
… predicted by decreased connectivity between the prelimbic cortex and the anterior cingulate cortex with the posterior dorsomedial striatum. In summary, this thesis supports previous work implicating impulsivity as a vulnerability marker for substance dependence in humans, and as a marker for …
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Serotonin Modulates the Maturation of the Medial Prefrontal Cortex and Hippocampus: Relevance to the Etiology of Emotional and Cognitive Behaviors
… with reduced intrinsic excitability. Conversely, prelimbic (PL) layer 2/3 neurons displayed normal dendritic arborization, but increased intrinsic excitability. Together, these changes produce a reduced IL/PL output ratio. In order to probe the functional consequences of these changes, we …
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Anorexia nervosa: investigation of markers of neuroinflammation, oxidative stress and synaptic plasticity using the activity-based anorexia rat model.
… brain regions and subregions [PCF (limbic and prelimbic), dHPC (DG, CA1, CA3), vHPC (DG, CA1, CA3) NAc shell (dorsomedial, ventromedial, ventrolateral) and NAc core]. We observed an increased expression of Arc and c-Fos in many of the areas under investigation in the ABA animals, suggesting …
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Neural Plasticity in the Amygdala Across the Development of an Incentive Cocaine Seeking Habit
… inputs, namely the orbitofrontal cortex, the prelimbic cortex, and the infralimbic cortex. Using the immediate early gene cFos as a marker of cellular activity, I performed RNAscope on brain sections encompassing the PFC to explore the behavioural relevance of specific PFC-BLA projections. …
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Analisi dell’espressione della fosfoERK quale strumento di indagine per la caratterizzazione della sensibilità alle sostanze d’abuso in linee di ratti geneticamente selezionati
… sP vs sNP rats, on ERK phosphorylation in Acb, prelimbic (PrL) and infralimbic (IL) prefrontal cortex (PFCx) and nuclei of the extended amygdala (BSTL, CeA and BLA). The results of these experiments demonstrate 1) that morphine significantly decreased Acb pERK expression, as determined by …