Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"preimplantation development"”.
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Micrurgy and in Vitro Preimplantation Development of Rabbit Embryos
Made available in DSpace on 2014-12-14T15:29:41Z (GMT). No. of bitstreams: 1 7820989.pdf: 3167012 bytes, checksum: cab7a5f928b1087fdaf1d78e04bf8b3d (MD5) Previous issue date: 1978
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The Impact Of Mitochondria On Preimplantation Development In The Rhesus Macaque
… cellular and molecular properties of oocytes and preimplantation embryos. A key component of all cells, including oocytes and embryos, is the mitochondrion, which produces energy and maintains its own DNA for encoding proteins necessary for energy production. Defects in either the proteins …
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Role Of Maternal Sin3a In Reprogramming Gene Expression During Mouse Preimplantation Development
… activation, which is essential for continued development beyond the 2-cell stage. Superimposed on zygotic genome activation and reprogramming of gene expression is formation of a chromatin-mediated transcriptionally repressive state that promotes repression of genes at the 2-cell stage. …
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The role of mir-290-295 in murine embryonic and germ cell development
… lethality. Mir-290-295 is not required for early preimplantation development but is instead required for later postimplantation development. In surviving mir-290-295 deficient embryos, female but not male fertility is compromised. This impairment in fertility arises from a defect in migrating …
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Involvement of mitochondrial transcription factor A (TFAM) in porcine gametogenesis and preimplantation embryo development
… and distribution of TFAM in the gametes and preimplantation embryos of a domestic pig (Sus scrofa), a livestock species of major economic significance. We hypothesized that TFAM will be expressed at high levels in oocytes and embryos and that sperm mitochondria should be devoid of TFAM since …
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DNA methylation in early mammalian development
… DNA methylation profiles across pre-implantation development to identify the targets and characterize the dynamics of global demethylation that lead to totipotency and the subsequent changes to embryonic specification. In Chapter 1, I validate and refine the decades old model for DNA methylation …
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Label-free Optical Approaches for the Non-invasive Assessment of Embryo Quality
… holds great promise for the evaluation of preimplantation embryo quality. In this thesis, I investigated whether optical imaging approaches can non-invasively detect changes in embryos during preimplantation development that are associated with embryo quality. I confirmed that label-free …
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Towards A Unified Model Of Sperm Chromatin Structure
… regulatory factors may reflect the accelerated preimplantation development of the murine embryo. Sites of Ctcf retention in mature sperm were considered within a novel model of spermatogenic nuclear remodeling.</p>
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IMPACT OF NUTRIENT IMBALANCE ON THE EPIGENETIC SIGNATURE AND GENE EXPRESSION OF BOVINE EARLY EMBRYOS
The Developmental Origins of Health and Disease (DOHaD) theory emphasizes the long-term health implications of maternal nutritional imbalances during pregnancy. This study focuses on how variations in energetic substrates during preimplantation development affect gene expression, differential …
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Effect of a maternal inflammatory challenge during the preimplantation period on offspring development and phenotype
The preimplantation mammalian embryo is sensitive to its immediate surroundings: alterations to its in vitro or in vivo environment can affect not only the immediate events of blastocyst formation, but can also give rise to long-term phenotypic consequences during fetal and/or postnatal life. For …
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Maintaining Proper Levels of DNA Methylation Marks Through the TET Family is Critical for Normal Embryo Development in Pigs
… and the changes are essential for normal embryo development. Ten-eleven translocation (TET) methylcytosine dioxygenases are implicated in DNA demethylation by catalyzing the conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). The three members of TET protein family, TET1, …
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Notchless Interacts with Multiple Signaling Pathways during Mouse Peri-Implantation Development
… signaling pathways during peri-implantation development. I present data that: 1. Refute the presumption that Nle1 functions as a negative regulator of NOTCH during pre-implantation development; 2. Demonstrate that mutations in Nle1 lead to mis-expression of several members of the Wnt pathway; …
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Molecular and Functional Analysis of two Gene Trap Mouse Lines
Um ein besseres Verständnis über die regulatorischen Mechanismen der embryonalen Säugetierentwicklung zu erlangen ist es wichtig neue Gene, die an diesem Prozess beteiligt sind zu isolieren und zu charakterisieren. Eine hilfreiche Methode um die Genfunktion während der Entwicklung zu studieren ist …