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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"pregnenolone"”.
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STUDIES ON THE SUBCELLULAR LOCALIZATION OF 3-BETA- HYDROXYSTEROID DEHYDROGENASE IN STEROIDOGENIC CELLS
… steroids are initially transformed into pregnenolone by the enzyme P450scc (CYP11A1). Pregnenolone is then converted into various steroid intermediates by 3-β hydroxysteroid dehydrogenase/ Δ5-Δ4 isomerase (HSD3B), a process crucial for producing key hormones like progesterone and …
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Modulation of Cerebral Artery Smooth Muscle BK Channel Function by Neurosteroids
… effects, including but not limited to, pregnenolone and progesterone, these effects have been mainly attributed to the actions produced by the activation of traditional steroid receptors. Importantly, both pregnenolone and progesterone are currently under investigation for clinical …
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Isoflurane : interaction with hepatic microsomal enzymes
… from phenobarbital-, β-naphthoflavone- and pregnenolone-16α-carbonitrilepretreated and untreated rats. One or more of the cytochrome P-450 isozymes induced by phenobarbital and pregnenolone-16α-carbonitrile appear to defluorinate isoflurane, but those induced by β-naphthoflavone do not. From …
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Mechanistic Studies of Two Steroidogenic Cytochromes P450, CYP17A1 and CYP21A2
… responsible for hydroxylating the 17-position of pregnenolone or progesterone and cleaving the 17,20-carbon,carbon-bond of its hydroxylated products, which leads to the formation of androgens. The latter activity makes the inhibition of this enzyme a target for the treatment of prostate cancer. …
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ΣΥΝΘΕΣΗ ΤΡΟΠΟΠΟΙΗΜΕΝΩΝ ΣΤΕΡΟΕΙΔΩΝ ΕΣΤΕΡΩΝ, ΜΕ ΠΑΡΑΓΩΓΑ ΤΗΣ Ν, Ν-ΔΙΣ(2-ΧΛΩΡΟΑΙΘΥΛ)ΑΝΙΛΙΝΗΣ ΚΑΙ ΒΙΟΛΟΓΙΚΗ ΔΡΑΣΗ ΑΥΤΩΝ
… DEHYDRO-EPI-ANDROSTERONE, TESTOSTERONE, ESTRONE, PREGNENOLONE AND ANDROSTANALONE.
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Function and pharmacology of TRPM3 ion channel
… reports. In addition, TRPM3 was activated by pregnenolone sulphate. Hydrophobicity analysis of the TRPM3 amino acid sequence revealed a short and reasonably unique peptide in the 3rd extracellular loop (E3) region, to which polyclonal antiserum (TM3E3) was produced. Extracellular application …
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The interaction of three local anaesthetic agents with hepatic microsomal cytochrome P-450
… P-450 elevated with phenobarbital and/or pregnenolone-16α-carbonitrile were shown to play an important role in the binding of lidocaine to cytochrome P-450. Cytochrome P-448 did not appear to be involved in the binding of lidocaine to cytochrome P-450. These findings are supported by the …
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Mechanisms controlling in vitro progesterone synthesis by the ovine placenta
… incubated either in the presence or absence of pregnenolone and the tissue was subject to addition of either human Chorionic Gonadotropin (hCG), 3’, 5', cyclic adenosine monophosphate (cAMP), luteinizing hormone-releasing hormone (LHRH) or no additional treatment. Progesterone concentration in …
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Steroidogenic cell populations in follicles of the chicken ovary
… P450, and aromatase cytochrome P450 to identify pregnenolone-, androgen-, or estrogen-producing cells, respectively.
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The Pharmacological Characterization of Hco-UNC-49, a GABA-gated Chloride Channel from the Parasitic Nematode Haemonchus contortus
… the molecules penicillin G, propofol and pregnenolone sulfate all had similar effects on Hco-UNC-49 as reported previously for Cel-UNC-49. On the other hand, Hco-UNC-49 appears to be less sensitive to picrotoxin inhibition compared to what has been reported for Cel-UNC-49. Novel effects of …
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Biosynthesis and Signaling of Glucocorticoids and Progestins and Their Effects on Myelin Synthesis in Schwann Cell/neuronal Co-Cultures
… synthesize many different steroids. When [7-3H] pregnenolone and [1,2-3H] deoxycorticosterone were added to the co-cultures these precursors were converted to several steroid metabolites. The expression of the major steroidogenic enzymes were determined in the co-cultures. The spatial and …
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Intrauterine position in pigs: effects on conceptus development and fetal fluids steroid content
… Fetuses examined from ovariectomized (OVX) pregnenolone (PS)-treated gilts showed differences in placental weight, allantoic fluid estrone and androstenedione content and amniotic fluid androstenedione content as a result of intrauterine position. Fetuses from OVX gilts treated with either …
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Sperm release from the oviduct reservoir
… Progesterone and the related steroid pregnenolone release 40-60% of sperm from oviduct cells and immobilized glycans. Progesterone release requires the ion channel CatSper and protein degradation by proteasomes. Finally, the development of sperm hyperactivation was sufficient to induce …
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In vitro progesterone and estrone synthesis by the porcine placenta and endometrium at 30, 60 and 90 days of gestation
… to gain a better understanding of the effects of pregnenolone (P₅), human chorionic gonadotropin (hCG) and 3' 5', cyclic adenosine monophosphate ( cAMP) on porcine placental and endometrial production of progesterone (P₄), testosterone (T) and estrone (E₁) at 30, 60 and 90 days of gestation. …
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Understanding the mechanism of androgen biosynthesis
… enzyme responsible for the 17-hydroxylation of pregnenolone and progesterone as well as the subsequent 17,20 carbon-carbon bond scission of its hydroxylated products in a reaction that constitutes the first committed step of androgen formation. Though over 40 years have passed since discovery of …
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Ire1 regulates cyp11a1 transcription to mediate steroidogenesis in the ovary
… forskolin stimulated CYP11A1 up-regulation and pregnenolone biosynthesis suggesting a general mechanism. In conclusion, IRE1 is critically important in activating CYP11A1 transcription. With global concerns increasing over declining fertility in humans, IRE1 represents a novel mechanism …
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Assessing the Role of the Transient Receptor Potential Melastatin 3 (TRPM3) Ion Channel in Visceral Sensation
… inhibitor isosakuranetin suppressed CIM-0216 and pregnenolone sulphate sodium (PSS)-induced increases in intracellular Ca2+. The magnitude of CIM-0216 and PSS-induced increases in intracellular Ca2+ were significantly greater in neurons from mice with colitis compared to healthy mice. …
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Pharmacological Modeling and Regulation of Excitatory Amino Acid Transporters (EAATs)
… of sulfated neuroactive steroids, including pregnenolone sulfate (PREGS), were found to selectively increase the ability of EAAT1 to transport atypical substrates like D-aspartate and L-cysteine, but not L-glutamate. The effect was rapid, reversible, limited to a select group of sulfated …
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Elucidation of the Specificity of Neuroactive Steroids and Related Compounds at the at the Vesicular Glutamate Transporter
… into synaptic vesicles. This work identifies pregnenolone sulfate, along with 5,6-QDC, as competitive inhibitors of VGLUT (K i values of 107 and 228 μM, respectively). These two molecules display specificity for VGLUT, with respect to other sites on the synaptic vesicle (i.e., …
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Pharmacological Modeling and Regulation of Excitatory Amino Acid Transporters (EAATs)
… of sulfated neuroactive steroids, including pregnenolone sulfate (PREGS), were found to selectively increase the ability of EAAT1 to transport atypical substrates like D-aspartate and L-cysteine, but not L-glutamate. The effect was rapid, reversible, limited to a select group of sulfated …
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