Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"prefoldin"”.
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ANALYZING THE FUNCTIONS OF PREFOLDIN COMPLEX IN NEUROBLAST HOMEOSTASIS OF DROSOPHILA MELANOGASTER
Prefoldin is a molecular chaperone that regulates tubulin function in mitosis. In this thesis, I show that Prefoldin depletion results in disruption of neuroblast polarity, leading to neuroblast overgrowth in Drosophila larval brains. Co-depletion of Prefoldin and Partner of Inscuteable (Pins) …
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Novel effects of Prefoldin Pathway on Intestinal Homeostasis via Dietary Restriction in Drosophila melanogaster
<p>The field of medicine research is embroiled in a battle against aging. Particular focus is on the extension of lifespan and health-span. Lifespan duration is affected by many factors, one of which is the maintenance of the intestines of the organism. Homeostasis of the intestines is controlled …
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The Role of Phosducin-like Protein and the Cytosolic Chaperonin CCT in G beta gamma dimer Assembly
… role of PhLP as a co-chaperone similar to prefoldin. Docking studies with the atomic model of PhLP generated from several known structures of the homologous phosducin (Pdc) together with the immuno-EM studies have provided more details of the complex structure and predicted some regions of …
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Zebrafish Mutagenesis Study of Host Determinants of Mycobacterial Infection Outcome
This thesis describes a large-scale forward genetic screen in zebrafish for host determinants of mycobacterial infection outcome that I participated in. Zebrafish larvae from families randomly mutagenized with N-ethyl-N-nitrosourea were infected with Mycobacterium marinum and monitored over time. …