Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"predictive marker"”.
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Aberrant DNA methylation as a diagnostic and predictive marker of ovarian cancer
… shown by MSP to be a potential early epigenetic marker methylated in 75% of early stage ovarian tumours. 87.5% of the early stage tumours examined were methylated in at least one of four loci (LMX1A, OPCML, RASSFIA or HIC1). The clinical application of this group of methylated CGIs was examined …
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Insights into breast cancer: New familial patterns and identification of a potential predictive marker
The last proportion of heredity in breast cancer has proven to be somewhat elusive despite massive attempts to identify the associated factors. Approximately 50 percent of breast cancer caused by familial factors is currently explained. The five-year survival for breast cancer patients is …
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Identifying potential genetic, phenotypic and epigenetic predictive markers in the Toll-like receptor/Interleukin-1 domain innate immune signalling pathway for severe gastrointestinal toxicity risk following 5-Fluorouracil-based therapy
… of life whilst receiving 5-FU-based therapy. A predictive marker for severe GI toxicity risk is urgently required to identify patients at most risk of developing severe GI toxicity prior to receiving 5-FU-based therapy. This would not only allow at risk patients to be closely monitored whilst …
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Role of cyclin D1 as an estrogen receptor cofactor and the influence of hypoxia on estrogen receptor regulation, with focus on prognositic and treatment predictive features in breast cancer
… lines. Further, the prognostic and treatment predictive value of cyclin D1 and HIF-1 was analyzed in breast cancer patients receiving two years of tamoxifen versus no adjuvant treatment. The results indicated that ER heterogeneity in primary breast tumors was associated with cyclin D1 and …
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Sorghum hot water extract : influence of grain physico-chemical characteristics
… and time-consuming. The provision of a possible predictive marker(s) for sorghum hot water extract that is less complicated to determine, could be of great economical value to the brewer. Hot water extract was determined for 43 sorghum cultivars and then compared to various physico-chemical …
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SOX2 is Associated with Changes in DNA Damage Repair and Cell Cycle Gene Expression and Regulates E2F1
… appropriate treatment option. One potential biomarker my lab has identified is SOX2. The expression of SOX2 was linked to an increased Gleason score at diagnosis and decreased time to metastasis after biochemical recurrence. Previously, SOX2 was found to promote lineage plasticity and resistance …
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Prognostic Value of Bone Marrow Micrometastasis Detected by Nnested RT-PCR for Cytokeratin 19 and Mammaglobin in Breast Cancer
… nested RT-PCR for cytokeratin 19 can be a useful predictive marker for distant recurrence of breast cancer.
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Risk of cervical lymph node metastasis in papillary thyroid carcinoma: Correlations with lymphangiogenesis and ultrasound features
… associated with LNM and thus, could be a useful predictive marker for cervical LNM.
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Medicina de precisión: ncRNAs como herramienta diagnóstica para pacientes con intolerancia a estatinas de alto y muy alto riesgo cardiovascular
… consider it a priority need to identify biomarkers with discriminatory accuracy for a true diagnosis of statin intolerance (SI) in these patients. MicroRNAs (miRNAs) have emerged in recent years as molecules that offer valid biomarker roles involved in the regulation of multiple cellular …
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Novel Imaging-Based Techniques Reveal A Role For Pd-1/Pd-L1 In Tumor Immune Surveillance In The Lung
… PD-L1, but immune phenotype alone is not a predictive marker of effective anti-tumor responses. Through a novel method in which we quantify T cell interactions, we show that T cells are largely engaged in interactions with dendritic cells in the tumor microenvironment. Additionally, we show …
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IDENTIFYING, CHARACTERIZING AND VERIFYING NOVEL C-MAF FUNCTIONS IN T CELL DEVELOPMENT AND APOPTOSIS
… immunity, but also evaluate c-Maf function as a predictive marker of autoimmune diseases.
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EphA4 Influences Blood Brain Barrier Disruption and Endothelial Cell Response following Traumatic Brain Injury in a Mouse Model
… driver of this secondary injury response and predictive marker of prognosis following TBI. Although BBB disruption plays a role in subsequent edema, inflammation, and the overall TBI outcome, the molecular mechanisms responsible for its regulation remain to be investigated. A large family of …
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Interleukin-6 and Interleukin-10 concentrations as predictors of patient outcome following major traumatic injury
… interleukin-6or interleukin-10 as potential biomarkers for the early detection of complications and poorclinical outcome following trauma. Metabolomic analysis was also conducted in parallel tovalidate methodology and identify new molecules and pathways involved in the response totrauma. …
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Genetic and environmental influences on cord blood atopic markers and on atopic sensitisation in infancy
… serum immunoglobulin E (CBsIgE) is an excellent predictive marker for the subsequent development of atopic disease. Other potential predictive atopic markers such as cord blood eosinophils, platelets and anti-cow's milk serum IgG have also been suggested as having possible predictive relevance …
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Il-2 Regulation of Il-24 Expression Leads to Growth Suppression of Melanoma Cells
Melanoma is known to be highly resistant to chemotherapy. Treatment with high dose IL-2 has shown significant clinical benefit in a minority of metastatic melanoma patients and has lead to long term survival in a few cases. However, this treatment is associated with excessive multiorgan toxicities, …
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Prognostic and Treatment Predictive Markers Associated with Cyclin D1 Gene Amplification and Epithelial-Mesenchymal Transition in Breast Cancer
… strategies is pivotal. Discovery of novel biomarkers potentially predicting treatment response as well as the clinical course of breast cancer is essential to effectively improve therapies and diagnosis. The main goal of this thesis was to identify putative markers for prediction of clinical …