Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"preclinical study"”.
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Sympathetic control of carotid body excitability in hypertension: A preclinical study
Previous studies have demonstrated that the integrity of carotid bodies is essential for the development and maintenance of hypertension via exacerbated sympathetic drive. Carotid bodies of spontaneously hypertensive (SH) rats exhibit both hypertonicity and hyperreflexia (i.e., hyper-excitability), …
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Preclinical Study of Potential Antiglioma Novel Tetrahydroisoquinoline Analogs: Pharmacokinetics and Mechanism of Action
… of last generation compound EDL-155. Its preclinical pharmacokinetics were characterized in this dissertation project. In male Sprague Daley (SD) rats, after 10 mg/kg intravenous injection, total body clearance (CL) of EDL-291 was 209 mL/min/kg (CV 23.7%), 39% lower than EDL-155 but still …
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A Preclinical Study of Radiation-Induced Lung to xicity When Irradiating In A Strong Magnetic Field
<p>The purpose of this work was to evaluate the effect of a strong, transverse magnetic field on the severity of radiation-induced lung damage in mice. This data can be used to support the safe clinical implementation of MRI-guided radiation therapy systems.</p> <p>Monte Carlo simulations and EBT3 …
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Cyclodextrins as a suitable carrier for the induction of feeding and analgesia by Delta-9 THC: a preclinical study in the female rat
Achieving consistent and effective oral delivery of Δ9-tetrahydrocannabinol (THC) remains challenging due to the compound’s low aqueous solubility, extensive first-pass metabolism, and variable pharmacokinetics. This research explores whether complexing THC with hydroxypropyl-β-cyclodextrin …
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Development and translation of label-free functional microscopy based on optical coherence tomography
… sensitive (PS) OCT techniques for clinical and preclinical applications. This goal includes four specific aims. The first aim is to develop a clinical imaging system to image the anatomy and microvasculature of human skin. The second aim is to develop a high performance post-processing algorithm …
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The Use of Preclinical Models to Improve the Treatment of Retinoblastoma
… It is often difficult to carryout a clinical study for pediatric cancers due to the small patient population. Retinoblastoma, a pediatric cancer of the eye, is one example of a pediatric cancer that can benefit from preclinical studies. Over the years various retinoblastoma rodent models have …
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Development of a Human Lung Cancer Cytochrome C-GFP Reporter Cell Line to Study Anti-cancer Drug Responses in Apoptosis Pathways
… Staurosporine, and Tarceva. The result from this study illustrated that the dynamic release of cytochrome C-GFP is dependent on the cell types and doses. We have also developed a system to investigate the anti-cancer drugs response in a sequence of time interval, Microfluidic Duration Device. The …
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Characterization of physicochemical properties of pan-frying bacon fat and its potential effects on breast cancer progression
… bacon fat diet on breast cancer progression in preclinical (murine) models, including the impact on primary tumor growth and metastatic potential. The syngeneic allograft mouse model BALB/c mouse strain and FVB mouse strain were selected. In each preclinical study, mice were randomly placed on …
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COMBINATORIAL MOLECULAR PHARMACOLOGICAL AND PRECLINICAL STUDIES OF AN EPIGENETIC ANTICANCER DRUG, 3-DEAZANEPLANOCIN A, IN RATS
… through inhibition of EZH2 protein to date, the preclinical study of DZNep was thus performed. No observable adverse effect dose (NOAEL) of DZNep determined was 10 mg/kg in Sprague Dawley (SD) rats. DZNep caused nephrotoxicity and renal atrophy in rats in a dose-dependent manner but had no …
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Development of a Tubular Biological Tissue-Engineered Heart Valve with Growth Potential
… and their function and growth potential in preclinical testing. Specifically, engineered tissue tubes were fabricated by entrapping dermal fibroblasts in a fibrin gel and allowing them to replace it with circumferentially-aligned extracellular matrix. Following in vitro culture, the …
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Innovative Orthodontic Treatment using Piezosurgery
… trials and multi-level biological analyses in a preclinical setting. Based on two randomized controlled trials, the present work demonstrates the first clinical evidence of tooth movement facilitation with piezocision. A reduction in treatment time of respectively 40% and 36% was observed in …
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Charge-based transport and drug delivery into cartilage for localized treatment of degenerative joint diseases
… the necessity of using larger animal models for studying joint space transport and pharmacokinetics. Avidin's neutral counterpart (Neutravidin) was completely cleared from the joint space of both rats and rabbits within 24h. We then conjugated Avidin with the glucocorticoid, dexamethasone, using …
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ELUCIDATING THE ROLE OF HET0016 IN AMELIORATING 20-HETE INDUCED OXIDATIVE STRESS AND LIVER INJURY IN B-THALASSEMIA: A NOVEL THERAPEUTIC TARGET
… acid (20-HETE) activity. Aim: The aim of this study is to assess the efficacy of N-Hydroxy-N'-(4-butyl-2-methylphenyl)-formamidine (HET0016), an inhibitor of 20-HETE formation, in reducing 20-HETE-mediated oxidative stress and injury in the livers of mice affected by β-thalassemia. Methods: …
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Development of Therapies to Treat Polycystic Kidney Disease
… as long-term treatment for PKD. The first preclinical studied showed that high (20 mg/kg BW) dose pioglitazone, a PPARγ agonist, inhibited cyst growth in the PCK rat model, a slow progressing model, of PKD. To continue to look at the effects of the PPARγ agonists another preclinical study …
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Investigation of novel therapeutic strategies in B cell and antibody mediated disease
… anti-BLyS antibody, in an experimental medicine study in kidney transplant recipients. The rationale for this study was based on published studies showing that B cells activate alloreactive T cells and secrete human leukocyte antigen (HLA) and non-HLA antibodies that negatively affect graft …
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Investigating mitochondria alterations in esophageal pathologies
… were unexplored. Given this, we conducted a preclinical study aimed at examining the efficacy of the NSAID, diclofenac (DCF), as a novel therapeutic agent in ESCC. In addition to robustly diminishing the viability of multiple ESCC cell lines, including TE11, KYSE150 and KYSE 410, without …
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Bio-behavioural evaluation of efavirenz and Δ9-tetrahydrocannabinol alone and in combination in rats with respect to psychosis and anxiety
… resistance to antiretroviral therapies. Few preclinical studies have sought to elaborate on the addictive profile of EFV. One study noted that the pre-dominate behavioural profile of EFV is similar to that of the hallucinogen, lysergic acid diethylamide (LSD), with EFV having weak partial …