Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 44 for “"preclinical model"”.
-
The crucial role of reelin in a preclinical model of depression
… with corticosterone (CORT), a well characterized model of depression, exhibit a depression-like phenotype. Additionally, CORT treated rats have shown a downregulation in reelin. Reelin is a large glycoprotein that has been implicated in many psychiatric illnesses. Reelin is involved in stimulating …
-
A Preclinical Model of Ionizing Radiation and TNF-alpha Gene Therapy for Cancer
… an aggressive, rapidly growing glioma tumor (C6) model. Plasmid DNA is an attractive vector system for delivery of foreign genes into eukaryotic cells due to its advantages including low immunogenicity <em>in vivo</em>, lesser toxicity and relatively low cost. We have constructed a plasmid-based …
-
Investigating the cerebral/pulmonary axis following traumatic brain injury in a preclinical model
… percussion injury (FPI) in an in-vivo murine model. In the murine FPI model, alongside cerebral inflammation (associated with neuronal damage and the infiltration of inflammatory cells), there is significant neutrophil accumulation within the pulmonary interstitium 6 and 24 hours after TBI. …
-
A multimodal lens into vascular recovery in a preclinical model of peripheral arterial disease
… targeted at \avbt, to establish an optimal preclinical model of PAD. The third chapter builds on the first and second, by developing a multimodal approach for vascular imaging that enables simultaneous evaluation of molecular and physiological changes during angiogenesis. Finally, the fourth …
-
SEX DIFFERENCES IN GENE EXPRESSION AND PAIN-RELATED BEHAVIORS IN A PRECLINICAL MODEL OF MIGRAINE
… shown that CGRP levels are increased in animal models of inflammatory pain and in the external jugular vein of humans during migraine attacks. The CGRP receptor is comprised of three proteins: a G-protein coupled receptor called calcitonin-like receptor (CLR), a receptor activity-modifying …
-
Radioimmunotherapy of Metastatic Disease - Studies of Alpha- and Beta-particle-Emitting Radionuclides in a Preclinical Model
… many carcinomas. A syngeneic rat colon carcinoma model was used in all the studies. The aim of the work described in this thesis was to evaluate the therapeutic effects and toxicity of mAbs labeled with different activities of these two radionuclides, administered separately, or administration of …
-
Examination of the effect of a diet high in vitamin D in a preclinical model of fragile X syndrome.
… (mTOR) and mGluR signaling cascades. Murine models of FXS resemble behaviorally and molecular characteristics of ASD, making this model a valuable tool for studying this disorder. Currently, there is no treatment for FXS, emphasizing the critical need for new interventions. Previously, …
-
Investigating Sex-Specific Responses in a Preclinical Model of Traumatic Brain Injury: Development of Chronic Depression-Like Behavior and Glutamatergic Protein Changes
… Using a clinically-relevant rodent model of concussion, this work sought to elucidate chronic glutamatergic changes occurring in the brain in association with the development of depression-like behavior following injury. Delayed-onset deficits in social and self-care behaviors were …
-
THE USE OF PREVENTATIVE CANNABIDIOL, CANNABIGEROL, AND MITRAGYNINE TO AMELIORATE MECHANICAL SENSITIVITY OF PACLITAXEL-INDUCED PERIPHERAL NEUROPATHY IN FEMALE MICE
… could offer effective pain relief. These preclinical studies have demonstrated the antiallodynic effects of Cannabidiol and Cannabigerol from Cannabis Sativa along with Mitragynine from Mitragyna Speciosa. Not only did they show reduction in mechanical allodynia, but Mitragynine studies …
-
Impact of mtDNA Signature on Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Progression and Cardiometabolic Outcomes in Mice
… and hepatocellular carcinoma. A review of preclinical models identified the Mitochondrial-Nuclear eXchange (MNX) mouse as a robust tool for isolating mtDNA effects from nuclear genetic background. The experimental study uses wildtype and MNX mice carrying distinct mtDNA signatures, exposed …
-
Locomotor activity does not predict individual differences in morphine self-administration in rats
… locomotor activity in a novel environment, a preclinical model of sensation-seeking, and individual differences in acquisition of i.v. morphine self-administration (SA) in rats. A secondary goal was to evaluate the relationship between activity and elasticity of demand (reinforcing efficacy) …
-
Food processing modulation on breast cancer
… correlated with breast cancer metastasis in the preclinical model. This is the first study to investigate the causal link between thermally abused oil characteristics and its direct negative biological responses in a preclinical model of breast cancer. Future studies will be continued to …
-
Characterization of the Dunkin Hartley guinea pig as a non-transgenic and multimorbid model of brain aging
… using genetically engineered pre-clinical models, that express a specific brain aging pathology. Recent discoveries, however, have identified a dynamic whole-body "inflammaging" phenotype that exists with, and likely contributes to, AD/ADRD onset and progression. Currently, we do not have …
-
HUMAN DPP4/CD26 TRANSGENIC MICE AS SURROGATE MODELS FOR MERS
… an ongoing public health threat. Animal models, especially small animal models that simulate human disease are needed for studies of pathogenesis and development of vaccines and antivirals for prevention and treatment of MERS-CoV infection and disease. Mice and other commonly used …
-
Behavioural and cellular basis of the vulnerability to develop compulsive heroin seeking habits
… habits. Over the last decade clinical and preclinical studies have begun to shed light on the psychological and neural basis of the individual vulnerability to cocaine addiction, but despite the epidemic in opiates addiction in the USA and incremental opioid drug abuse and addiction in the …
-
Establishment and Improvement of Preclinical Murine Models of Severe Scrub Typhus to Define Immune Signatures and Pathogenic Mechanisms
… While there are many established murine models of scrub typhus, differences in route of infection, host resistance, and clinically unrelated pathologic outcomes diminish the usefulness of model studies. Therefore, there is a great need for the development of small animal models that …
-
Antioxidants in Normal and Epileptic Brain: Effect on Synaptic Plasticity, Neural Network Physiology, and Memory
… function has been found in human TLE and a mouse model of TLE. The Kv1.1 knockout (KO) mice, a preclinical model of TLE, display cognitive deficits and reduced hippocampal long-term potentiation. Thus, the contribution of excessive mitochondrial ROS to impaired hippocampal-mediated memory in …
-
Exploring the utility of the pig model for predicting bioavailability in humans
… there is considerable debate on which preclinical animal model is most appropriate for assessing oral bioavailability in humans. In order to streamline preclinical development, and reduce repeated testing in various animal models, it is necessary to get a better understanding which …
-
De-Risking PET Radioligand Discovery for Neurodegenerative Diseases
… localize to microglia in the brain tissue of a preclinical model of neuroinflammation and percent displacement did not exceed 50% of signal, requiring use of spleen in screening assays. Selectivity assessment showed numerous binding sites which prevents an interpretation of signal contribution. …
Page 1 of 3