Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 730 for “"preclinical"”.
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Optimal Screening for Preclinical Diseases
… we consider the optimal policy to screen for a preclinical disease while under limited budget. Our objective is to place any given number of screening epochs over an individual's lifetime, such that the probability of identifying the disease while preclinical is maximized. We make mild …
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Preclinical Modelling of Breast Cancer Drug Responses
… target the DNA damage response are entering preclinical drug development. However, the success of new therapies is dependent upon preclinical models which mirror clinical drug responses and accurately capture the heterogeneity of this complex disease. Patient-derived tumour xenografts (PDTXs) …
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Preclinical translation of therapeutic interventions for tendon injury
… goal of this dissertation was to improve the preclinical translation of therapeutic interventions for tendon and attachment injury. The body of work in this dissertation helps to translate therapeutic interventions for tendon and attachment injury by establishing (1) an improved animal model …
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Preclinical Pharmacology of the MDM2 Antagonist Nutlin-3a
… antagonist that is under investigation in preclinical models for a variety of pediatric malignancies, including neuroblastoma, retinoblastoma, leukemia, and rhabdomyosarcoma. In the current research, we conducted preclinical pharmacology studies of nutlin-3a to evaluate the synergistic …
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Preclinical imaging of prostate cancer using radiolabeled antibodies
… using animal models of prostate cancer. Preclinical SPECT/CT and PET/CT in vivo imaging modalities, ex vivo multi-radionuclide digital autoradiography, ex vivo activity measurements and immunohistochemistry were used to obtain biokinetics and specific activity uptake. In these studies, we …
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Optimization of preclinical profiling operations in drug discovery
… an internal service organization called Preclinical Compound Profiling (PCP) provides these services to the company as a whole. The purpose of this internship was to help PCP make significant improvements in cycle time and cost effectiveness without reducing the quality of information …
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X-ray phase contrast imaging of preclinical atherosclerosis
Atherosclerosis is the leading causes of mortality and morbidity in the world. While there are a plethora of methods for treating clinical atherosclerosis, the primary cause of mortality is acute coronary syndrome (ACS) following rupture of an atheroma, an event that is poorly predicted and remains …
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Preclinical Assessment of Intravenous Gene Therapy for GM2 Gangliosidosis
GM2 Gangliosidoses are a group of severe neurodegenerative lysosomal storage disorders characterized by the inability to catabolize GM2 Gangliosides, leading to a neurotoxic accumulation of the GM2 lipids within the central nervous system. The Hexosaminidase A (HexA) enzyme is a heterodimeric …
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Preclinical evaluation of novel calcium phosphate coated dental implants.
Contains fulltext : 82966.pdf (Publisher’s version ) (Open Access)
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Preclinical Investigations Of Genetic Correlates Of Alcohol Use Disorder
… has been done to characterize its genetic basis. Preclinical studies have been critical in describing the functional significance of genes associated with AUD and have advanced our understanding of the neurobiological underpinnings of this disorder. This dissertation presents a collection of mouse …
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Regulatory issues concerning the preclinical testing of synthetic peptides
… molecules and biological products as to which preclinical studies are to be conducted. Synthetic peptides present a unique scenario in which a case-by-case approach is needed for the conduct of preclinical studies. For peptides containing components that are already tested for genotoxicity, it …
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Preclinical pharmacokinetic evaluation of novel antimalarial and antituberculosis drug leads
Preclinical pharmacokinetics relies on efficient and accurate screening to select clinical candidates from early leads. Poor pharmacokinetic interpretation can disadvantage drug discovery by promoting inadequate compounds and expelling potential drug candidates. Objectives of this project included …
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PRECLINICAL PET IMAGING FOR TUMOUR CHARACTERIZATION: FOCUS ON HYPOXIA AND INFLAMMATION
… disease has allowed the use of these methods in preclinical research with the possibility to transfer directly the obtained results in clinic. In this thesis’s work we characterized two preclinical oncology models through the use of an animal PET instrument focusing on two processes correlated to …
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LOCOREGIONAL DELIVERY OF UNMETHYLATED CPG-OLIGODEOXYNUCLEOTIDES TO CANCER THERAPY: PRECLINICAL STUDIES
… and well tolerated, and might represent a preclinical basis for the design of clinical studies, even considering the ability of CpG-ODN to down-modulate DNA repair genes in tumor cell.
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PRECLINICAL EVALUATION OF A NOVEL NFIX INHIBITOR FOR MUSCULAR DYSTROPHIES TREATMENT
Le Distrofie Muscolari (DM) sono malattie eterogenee, caratterizzate da progressiva degenerazione muscolare che, nei casi più severi, causa dipendenza dalla sedia a rotelle e morte prematura per blocco respiratorio o disfunzione cardiaca. La migliore strategia terapeutica per le DM coinvolge …
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Medulloblastoma: New animal models, preclinical drug testing, and characterising immune infiltrates
… mice. Currently, the limited availability of preclinical mouse models that accurately represent subgroup-specific medulloblastoma has hindered the development of therapies that succeed in the clinical setting. In addition, the distinct lack of immunologically competent models has prevented the …
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Genetic determinants of rates of cognitive decline in preclinical Alzheimer’s Disease
… this reason, greater focus has been placed on preclinical trials and in turn both the identification of individuals at-risk for AD and, amongst these, those that are expected to decline over the course of a trial. While brain imaging to determine Aβ- amyloid burden has utility in identifying …
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The Use of Preclinical Models to Improve the Treatment of Retinoblastoma
… of a pediatric cancer that can benefit from preclinical studies. Over the years various retinoblastoma rodent models have been developed used to test various combination of broad-spectrum systemic chemotherapy. It was found form these studies that the combination of topotecan and carboplatin …
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The crucial role of reelin in a preclinical model of depression
Depression is a complex psychiatric disorder characterized by a cyclical disease course with repeated episode relapses. Rats treated for 21 days with corticosterone (CORT), a well characterized model of depression, exhibit a depression-like phenotype. Additionally, CORT treated rats have shown a …
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The development of preclinical strategies for facilitation of lead candidate selection
<p>Chapter 1 details a background of techniques used for modeling the blood-brain barrier (BBB). The BBB represents a diffusive barrier to both paracellular and transcellular movement of many compounds in and out of the brain. The main rate- limiting barriers of the BBB include exclusive tight …
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