Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"precancerous lesions"”.
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Nutrition and Physical Activity Cancer Prevention Guideline Adherence and Association with Circulating Concentrations of Vitamin D and Precancerous Lesions
… development and characteristics of premalignant lesions. Several individual lifestyle factors targeted by the ACS guidelines have also been associated with circulating concentrations of vitamin D metabolites. These associations suggest that adherence to the ACS guidelines may be related to …
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The effect of generational feeding of soy and genistein-supplemented diets on progression of precancerous lesions in colon of second generation male rats
Made available in DSpace on 2012-05-22T00:14:47Z (GMT). No. of bitstreams: 2 Jorud_Ingrid.pdf: 6962155 bytes, checksum: c952eff0bb6d12a10ff7100df49e0826 (MD5) license.txt: 4060 bytes, checksum: 5c881f39942655643ce300ca70345d3b (MD5)
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Early diagnosis of cancer using light scattering spectroscopy
… alteration of normal tissue structure such as precancerous and early cancerous transformations in various epithelia. LSS employs a wavelength dependent component of light scattered by epithelial cells to obtain information about subcellular structures, such as cell nuclei. Since nuclear atypia …
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Development of Electrochemical Immunosensor for Oral Cancer: Initial Outcome
… nations. Its frequent progression from precancerous lesions such as oral leukoplakia (OL) underscores the urgent need for an early, non-invasive diagnostic tool. This thesis investigates the use of a nanoengineered electrochemical immunosensor targeting the S100A7 protein, a biomarker …
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Comparative analysis of cervical disease progression in HIV positive women receiving ART and those not receiving ART in Cape Town, South Africa, from 2002 to 2011
… ranging from normal cytology to malignancy. Precancerous lesions (low and high grade squamous epithelial lesions (SIL)) are detectable and treatable. In addition, women who are infected with human immunodeficiency virus (HIV) have been shown to be more likely to be infected with HPV than …
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Diffuse reflectance spectroscopy of human colon tissue
… tissue epithelium and the detection of precancerous lesions. To investigate this, diffuse reflectance spectra were collected from adenomatous colon polyps (cancer precursors) and normal colonic tissue of patients undergoing colonoscopy. To analyze the data, an analytical model was …
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Quantitative spectroscopy for detection of cervical dysplasia
… detection of high-grade squamous intraepithelial lesions (HSIL), which are precancerous lesions with high risk of progression. Colposcopy, even when conducted by experts, is subject to significant diagnostic variability. The aim of the work presented in this thesis was to develop a non-invasive …
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The effects of chromosome number changes on mitotic fidelity and karyotype stability
… of chromosomes) is associated with a number of precancerous lesions and is believed to promote aneuploidy and tumorigenesis. While it is clear that chromosome mis-segregation causes aneuploidy, the effect of aneuploidy on chromosome segregation is less clear. Similarly, it is unclear whether and …
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The battleground of two Infections and a cancer: Human Papilloma Virus, premalignant lesions of the cervix and their interaction with Human Immunodeficiency Virus in southwestern Nigeria
… an increased risk of pre-invasive cervical lesions among HIV-infected women and the positive impact of treatment on the outcome. Given the various HIV strains in Nigeria and other West African countries, a different outcome may be expected. Unfortunately, limited information exists on the …
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Telomere-Driven Tetraploidy and its Relevance to Cancer
… from excessive telomere shortening in early precancerous lesions, promoting the evolution of a subtetraploid cancer karyotype.</p>
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Genetische Aberrationen mit einem Wachstumsvorteil in frühen Präkanzerosen des Urothels der Harnblase
… sections from 25/40 patients with pre-cancerous lesions of the bladder (13 hyperplasia, 12 dysplasia; those with preferably primary diagnosis; and further specimen from 7 carcinoma in situ, 3 pTaG1, 4 pT1G3). In addition 55 single cells of these precancerous lesions were laser-microdissected and …
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EVALUATION OF ENVIRONMENTAL FACTORS ON CANINE REPRODUCTION AND FERTILITY: INNOVATIVE STRATEGIES
… techniques and miRNomics, we found precancerous lesions and molecular dysregulation in both retained and scrotal gonads of affected patients. Interesting implications have emerged from this outcome especially concerning testicular neoplastic predisposition and the appropriate …
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Epitranscriptional Control of the Caspase-2—MDM2—p53 Axis: The Role of the m6A Writer in p53 Signaling.
… of genomic instability, often observed in precancerous lesions and advanced malignancies. The p53 tumor suppressor pathway, acting through the Caspase-2–MDM2–p53 signaling axis, provides a crucial surveillance mechanism that detects centrosome aberrations and prevents the propagation of …
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Functional Characterization of Bacterial Strains Enriched in Colon Adenomas and Their Impact on Colonic Epithelial Cells
… lining the colon or rectum, often evolving from precancerous lesions such as adenomatous polyps. Lifestyle factors—including diet, obesity, and physical inactivity—as well as hereditary predispositions contribute significantly to CRC risk. In recent years, increasing attention has been directed …
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Multi-omics approaches for diagnosis, prognosis and response to treatment of colorectal cancer.
… signature accurately discriminating CRC and precancerous lesions for a non-invasive diagnosis aimed at improving the effectiveness of current screening programs. Secondly, we pointed out the crucial role of the altered expression of 8q24-related microRNAs (miRNAs) for the initiation and/or …
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Mismatch Repair Deficient Neoantigen and Associated Circulating T-Cell Receptor Repertoires in Lynch Syndrome
… information on targetable neoAgs present in precancerous lesions. Understanding this landscape of pre-cancer derived neoAgs is crucial for intercepting cancer development effectively. Furthermore, the T-cell receptor (TCR) landscape of LS patients, particularly those that recognize these …
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Proteomics characterization of HPV-independent Vulvar Cancer Tumour Progression and Metastasis by Mass Spectrometry
… at the postmenopause age or with a history of precancerous lesions of differentiated VIN (dVIN), are classified as the high metastatic risk HPV-independent type vulvar cancer. Currently, most scientific efforts of vulvar cancer research are given to the low-risk HPV-dependent type, whereas …
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Immunhistochemische Analyse der Expression des CFR-1/PAM-1-Rezeptors auf Karzinomen und deren Präkanzerosen
Die humane Hybridomatechnologie ist ein guter Ansatz um tumorspezifische humane monoklonale Antikörper zu gewinnen. Der humane monoklonale IgM-Antikörper PAM-1 wurde aus einem Patienten mit Magenkarzinom mit Hilfe der humanen Hybridomatechnik isoliert und bindet an eine neue, post-transkriptionell …