Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"preadipocyte differentiation"”.
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Modulating adipogenesis via signaling pathways and cellular redox state
… cell physiology of human progenitor fat cells (preadipocytes). NO significantly promoted the differentiation process from immature fat cells to mature adipocytes. The proliferation of preadipocytes, however, was inhibited. The results of this thesis are especially helpful in the context of soft …
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Optimierung der Proliferation und Differenzierung humaner Präadipozyten durch den Einsatz von humanem Serum
… solution is adipose tissue engineering with preadipocytes. These adipogenic precursor cells have the ability to proliferate and differentiate into adipose tissue after transplantation. This study aimed at developing an optimal protocol for proliferation and differentiation of preadipocytes. …
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Increased fat oxidation in 3T3-L1 adipocytes through forced expression of UCP 1
… pRevTRE and was stably transfected into 3T3-L1 preadipocytes prior to differentiating them into adipocytes. A reporter gene (EGFP) was also transfected in parallel to optimize the transfection and preadipocyte differentiation conditions as well as to demonstrate regulated expression. Metabolite …
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Assessment of blue whiting protein hydrolysate bioactivities using cell culture models
… w/v dw) reduced triglyceride accumulation during preadipocyte differentiation (p<0.05), however none of the hydrolysates hydrolysed triglycerides in fully mature adipocytes. Interestingly, after SGID, all hydrolysates reduced triglyceride accumulation during differentiation and all except one …
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The role of Ad-36 and its E4orf-1 protein in modulating glycemic control
… are modulated by Ad36. In vitro, Ad36 increased preadipocyte differentiation, de-novo lipogenesis, and fat oxidation. Ad36 increased the proportion of small adipocytes in mice on a chow diet, whereas in HF-fed mice, Ad36 increased the proportion of large adipocytes. Adipose tissue macrophage …
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Präadipozyten auf neuartigen Textilmatrizes
… possibilities, adipose tissue engineering with preadipocytes offers new perspectives. Essential requirements for successful reconstruction are: adequate threedimensional construct, autologous cells, ideal cultivation conditions and sufficient vascularization for further in vivo experiments. This …
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A Human Pluripotent Stem Cell-Derived Model for the Investigation of Thermogenic Adipocyte Development and Function
… have developed a novel protocol for the in vitro differentiation of human pluripotent stem cells (hPSCs) to brown adipocytes (BAs). This thesis describes how this protocol can be employed to investigate candidate genes with proposed roles in BAT regulation. The thesis also investigates how …
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Identification of ITGBL1: A Novel Regulator of Adipogenesis
… are formed from their progenitor cells (the preadipocyte) when the body has a need to store excess lipid. It has been shown that the pathological expansion of white adipose tissue (WAT) leads to insulin resistance and cardiovascular disease. In spite of this clear observation, the mechanisms …
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Understanding C/EBPbeta LAP/LIP Transcriptional and Adipogenic Potential Through Regulation by HDAC1 and GCN5
… processes including cellular proliferation and differentiation. C/EBPβ is expressed as three isoforms (LAP*, LAP, LIP), translated from a single mRNA by a leaky ribosomal scanning mechanism. While LAP* and LAP have activating functions, LIP is recognized as being a repressor of transcription due …