Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"pre-replicative complex"”.
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Mechanisms that prevent DNA re-replication in the yeast Saccharomyces cerevisiae
… instability, a hallmark of tumorigenesis. To prevent re-replication eukaryotic cells must inhibit the re-initiation of replication start sites, or origins, across the genome. Examples of both Cyclin-Dependent Kinase (CDK)-dependent and CDK-independent mechanisms have been identified that …
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Phosphorylation of the replicative helicase by the S-phase kinase, Dbf4-Cdc7, at origins of replication in Saccharomyces cerevisiae
… protein called the Origin Recognition Complex (ORC). ORC recruits several proteins to the DNA, including the Mcm2-7 replicative helicase, to form the pre-Replicative Complex (pre-RC). Origins are activated by recruitment of other initiation factors to the pre-RC to form the …
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Coordination of origin licensing and cell cycle entry
… transmission of genetic material to progeny, the preparation for, initiation, and completion of DNA replication are closely coordinated with cell growth. Central to this coordination is the regulated assembly and activation of the pre-Replicative Complex (pre-RC) at specific sites of future …
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Genome-wide Footprinting Uncovers Epigenetic Regulatory Paradigms by Revealing the Chromatin Occupancy Landscape
… conditions. As these genomic processes require precise localization of DNA-binding factors, their dynamic temporal and spatial distributions provide dramatically different interpretations of a static genome sequence. DNA-binding factors must compete with nucleosomes, the basic subunit of …
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Role of WD domain-containing proteins in cell cycle progression
… genome starts from the loading of a six-subunit complex, Origin Recognition Complex (ORC), onto replication origins on the chromosome. The loading of ORC triggers the assembly of the pre-replicative complex (pre-RC) at origins, which licensed the origins prior to entering S phase. Unlike yeast, …
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Role of ORCA and ORC in chromatin organization and DNA replication
In eukaryotes, Origin recognition complex (ORC) proteins establish the pre-replicative complex (pre-RC) at the origins and this is essential for the initiation of DNA replication. In human cells, ORC is a highly dynamic complex with many separate functions attributed to sub-complexes or individual …
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ORCA/LRWD1, a novel player in the initiation of eukaryotic DNA replication
… process starts with the formation of the pre-replicative complex (pre-RC) prior to S phase, followed by the transition to the pre-initiation complex (pre-IC) that is required for DNA synthesis. The conserved canonical model of the pre-RC assembly includes an ordered recruitment of ORC, …
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Lokalisation, Regulation und Interaktionen muriner DNA-Replikationsproteine
… des hexameren ORC (origin recognition complex), der kontrovers diskutierte DNA-Sequenzen als Origins erkennt und bindet sowie als Landeplattform für weitere Proteinkomponenten dient. Der MCM-Komplex aus den sechs Untereinheiten Mcm2 7 komplettiert in Abhängigkeit von Cdc6 und Cdt1 den …