Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"pre-leukemia"”.
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Deconvolution of Leukemic Evolution Through Initiation, Progression and Relapse
… architecture of B-cell acute lymphoblastic leukemia (B-ALL) have been made, but our understanding of the mechanisms of leukemic initiation and progression remain limited. To gain clarity on these processes, a deeper understanding of the co-operative role of genetic aberrations, the …
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The influence of exercise training on the bone marrow microenvironment in obesity and cancer
… cells (MSCs), and marrow adipose tissue (MAT). Previous reports on the influence of age and diet on the BM suggest a role for lifestyle factors in modulating hematopoiesis and HSPC function, creating a more dysregulated environment more conducive to malignant disease. Exercise training …
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EXPLORING THE PRE-LEUKEMIC PHASE OF ACUTE PROMYELOCYTIC LEUKEMIA: INSIGHTS FROM STUDIES OF SINGLE CELL ¿OMICS¿
Acute Promyelocytic Leukemia (APL) is a distinct subtype of Acute Myeloid Leukemia (AML) driven by the oncogenic fusion protein PML-RAR, which acts as an aberrant transcription factor and blocks myeloid maturation at the promyelocyte stage. In vivo, the expression of PML-RAR is necessary but not …