Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"pre-implantation embryo"”.
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The Role of Merlin and Apicobasal Polarity In Endometrial Development and Homeostasis
… are necessary to secrete nutrients for the pre-implantation embryo. In addition, the endometrial gland is thought to be where endometrial cancer originates. While the endometrium is important for female fertility, relatively little is understood about how glands develop or how endometrial …
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The physiological significance of insemination in programming pregnancy outcome
… molecular environment of the uterus during the pre - and peri - implantation period of early pregnancy is critical for implantation success and optimal fetal and placental development. Perturbations to this environment not only have consequences for the success of pregnancy and neonatal health …
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Murine embryonic stem cells and hypoxia : growth kinetics, metabolism, and plating efficiency
There is reason to believe that embryonic stem cells would grow favorably in a hypoxic environment. These cells come from the pre-implantation embryo, whose native environment is the hypoxic mammalian reproductive tract. Growing stem cells in an environment with higher oxygen levels (i.e. the …
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Investigating the consequences of chromosome abnormalities arising during pre-implantation development of the mouse
The majority of human pre-implantation embryos created through in vitro fertilization (IVF) are mosaic as they are constituted of a mixture of diploid and aneuploid cells. Chromosome abnormalities are widely believed to contribute towards the relatively low success rates of IVF treatment. …
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Examining The Role Of Angiogenic Factors And Early Developmental Defects In The Pathogenesis Of Pre-Eclampsia In A Mouse Model, Bph/5
Pre-eclampsia (PE) is a devastating condition that affects 5-8% of pregnant women and is the leading cause of fetal and maternal deaths worldwide. The etiology of this disorder, however, is largely unknown. The BPH/5 mouse model is the only known rodent model that spontaneously develops the …
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Methods for Dissecting High Dimensional Single Cell RNA Sequencing Data
… accurately identify distinct patterns of mRNA expression that separate cells with distinct identities. However, several intrinsic properties of scRNA-seq data obfuscate our ability to extract biologically relevant information. Technical error can lead to the loss of resolution in cell similarity …
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Utilising Light in Assistive Reproductive Technologies
… per initiated cycle. The quality of oocytes and embryos are key determinants of IVF success. During an IVF cycle, multiple oocytes are harvested, and several embryos generated. Accurate assessment and ranking of these to identify those with the highest developmental potential would assist in …