Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"pre-60S"”.
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Structural Studies of the Nucleolar Stages of Ribosome Biogenesis in Yeast
… subunit (SSU, 40S) and a large subunit (LSU, 60S). At the interface of these subunits, the mRNA is decoded by the small subunit and peptide bond formation is catalyzed by the rRNA of the large subunit. The cell therefore requires the timely and accurate assembly of functional ribosomal …
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Chemical Biology, Biochemical and Structural Studies of MDN1, an AAA Protein Required for Ribosome Biogenesis
… ATPases and GTPases, are needed to remodel the precursors of ribosomes at fast time scales. Mdn1 is an essential dynein-like AAA protein (ATPases Associated with various Activities) that releases specific assembly factors from the precursors of 60S subunit of ribosomes. However, Mdn1's unusually …
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From ribosomal rotation to autism and cancer
… transition is controlled is not known. Here, we present evidence that the essential ribosomal protein L10 regulates this process in yeast ribosomes through a flexible loop located within 13 Å of the peptidyltransferase center. While deletion of the entire loop is lethal, viable mutants in …