Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"prazosin"”.
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Effects of Prazosin Treatment on Ethanol- and Sucrose-Seeking and Intake in P Rats
Background: Previous studies show that prazosin, an α1-adrenergic receptor antagonist, decreases alcohol drinking in animal models of alcohol use and dependence and in alcohol-dependent men. These studies extended previous findings by using a paradigm that allows for separate assessment of prazosin …
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Functional Roles of A1-adrenergic Receptors in the Bovine Inferior Alveolar Artery: Regulation of Contraction and Activation of Extracellular Signal Regulated Kinase
… mRNA in the BIAA using RT-PCR. Lack of [^Hj-prazosin specific binding in radioligand experiments and low affinity prazosin antagonism of NE-induced contractions suggested that the putative a.]L-AR may be coupled to contraction. The prazosin low affinity was not a result of prazosin removal …
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Microvascular Function and Remodeling Due to Chronic Changes Within the Skeletal Muscle Microenvironment
… was altered via femoral artery (FA) ligation or prazosin treatment. This dissertation includes three primary hypotheses and corresponding findings to examine the importance of alterations to the microenvironment on microvascular remodeling. Firstly, the loss of TIMP1 would enhance both ischemia …
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Effects of α1-receptor blockade on the hemodynamic responses to exercise in young normotensives and hypertensives
… occurred followed α1-receptor blockade with prazosin (HTN-α, NTN-α) and the other following placebo administration (HTN-p, NTN-p). At rest, HTN-p exhibited an elevated cardiac output (Q, p=.024) and MAP (p=.007). Resting Q was similar for HTN-α and NTN-α. Resting heart rate (HR) was …
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THE IMPORTANCE OF SEROTONERGIC AND ADRENERGIC RECEPTORS FOR THE INDUCTION AND EXPRESSION OF ONE-TRIAL COCAINE-INDUCED BEHAVIORAL SENSITIZATION
… ritanserin (a serotonergic receptor antagonist), prazosin (an adrenergic receptor antagonist), or a combination of the two drugs prior to an injection of EEDQ. To study the induction of behavioral sensitization, this series of injections was administered on PD 18 (24 h before the pretreatment …
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Investigation of a Model for the Study of Digital Perfusion in Equine Laminitis Using an Extract of Black Walnut (Juglans Nigra)
… lesions, and the efficacy of a single dose of prazosin were assessed for horses in the acute phase and in the convalescent phase of laminitis induced by an aqueous extract of BW.
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Molecular and Pharmacological Studies of Alpha1-AR Subtypes and their Signaling Pathways
… oligomer and mediaalone treated cells. [JFI]-Prazosin saturation binding experiments indicated that the antisense oligomer reduced cxib-AR density in a time- and concentration-dependent manner in cell membranes relative to control oligomer and media-alone treated cells. Competitive RT-PCR …
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Characterisation of novel alpha1-adrenoceptor ligands
… and C11 increased the dissociation rate of [3H] prazosin from the α1A-AR, suggesting allosteric modulation. C9 was further characterised and demonstrated to be a negative allosteric modulator of orthosteric ligands of the α1A-AR. The allosteric site was shown by docking of 4-aminoquinoline, C9, …
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Effect of Long-Term Hypoxia on Myocardial Alpha1- Receptors
… receptor system, we employed [<sup>3</sup>H-Prazosin] binding technique to characterize α<sub>1</sub>-adrenergic receptors in both fetal and adult sheep myocardial ventricular membrane preparations. Myocardial α<sub>1</sub>-adrenergic receptor density (Bmax) declined during developmental …
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Hypothalamic alpha adrenergic receptors and the regulation of LHRH release
… effect, blocked by the $\alpha\sb1$ antagonist prazosin. This data was the first to demonstrate that the specific activation of hypothalamic $\alpha\sb1$ adrenoceptors sharply stimulates the release of LHRH. This effect occurred in hypothalami from proestrus and ovariectomized rats with or …
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Arrhythmogenic potential of alpha-adrenoceptor stimulation in the rat heart
… was associated with a positive inotropic effect. Prazosin 10⁻⁸M (an alpha₁-adrenoceptor antagonist agent) produced a tenfold displacement to the right of the log concentration response curve of the positive inotropic effect of methoxamine. Prazosin 10⁻⁸M prevented the methoxamine induced fall in …
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Charakterisierung der Serotonin-Rezeptoren der Honigbiene Apis mellifera : von den Genen zum Verhalten
… dagegen blockiert die 5-HTWirkung vollständig. Prazosin und WAY100635 stellen partielle Antagonisten des Am5-HT1-Rezeptors dar. Der Am5-HT2_-Rezeptor stimuliert bei Aktivierung die Synthese des sekundären Botenstoffs Inositoltrisphosphat, was wiederum zu einer messbaren Erhöhung der …
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Analysis of Neural Contributions to Ultradian Oscillations of Blood Pressure and Heart Rate in Dogs
… decreased the power of HR and MAP oscillations. Prazosin (50ug/kg/hr), an alpha$\sb1$ antagonist, significantly decreased the power of MAP oscillations but increased the power of HR oscillations. These latter two series suggest that sympathetic innervation of both the vasculature and the heart …
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Muscle Metaboreflex Control Of Coronary Blood Flow And Ventricular Contractility During Dynamic Exercise In Normal And Heart Failure Conditions
… after systemic alpha-1 adrenergic blockade (prazosin 50-100 μg/kg). In control studies during alpha-1 blockade we observed significantly greater increases in CVC, CBF and PRSW, as well as CO and dP/dtmax, with metaboreflex activation vs. those seen without alpha-1 blockade. In heart failure …
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Central Alpha-Adrenoceptors and Behaviour
… these effects. Alpha1 antagonists such as prazosin on the other hand, produced sedation and potentiated clonidine's actions. However, α1 antagonists did not inhibit the pinna reflex or produce analgesia alone. The results suggest that central a2 receptor stimulation leads to sedation, …
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The effect of sex on cardiovascular dynamics in normal and diabetic rates
… vessels in both females and males. CHAPTER IV Prazosin (4 mg/kg) administration decreased the MAP in normal and diabetic rats to a comparable degree. It increased the vascular conductance in all three vascular beds in normal and diabetic rats with the greater increase occurring in the iliac and …
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Exploring the effect of alpha2 receptor on brain 5-HT via a mechanism-based pharmacodynamic model
… effect from al adrenoceptors effect, prazosin, an antagonist of α 1 adrenoceptors, was added to block α 1 adrenoceptors. Using the microdialysis method, the drug combination was examined in HP area and then DRN area to explore the drug effect on time course of 5-HT release in DRN and …
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Aspects of tic like behaviour and serotonergic control
… ketanserin, mianserin (5-HT2A/2C antagonist) and prazosin (alpha-1 adrenoceptor antagonist) were able to attenuate MK771-induced fore-paw-tremor and -licking. The 5-HT2C/2B antagonist SB200646A was without effect on blinking and fore-paw-licking but dose-dependently potentiated fore-paw-tremor. …
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The role of melatonin in red wine-induced cardioprotection
… effect of red wine was partially abolished with prazosin, a melatonin receptor 3 inhibitor (40±0.9%, p<0.001 vs. wine). Furthermore, the cardioprotective effects of regular moderate consumption of red wine or melatonin were abolished in STAT3 KO and TNF KO mice. In a model of ischemic heart …
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Pharmacotherapy for Social Anxiety Disorder and Posttraumatic Stress Disorder: New Meta-Analytic Approaches to Synthesising the Evidence
… For the treatment of PTSD, the alpha-blocker prazosin and antipsychotics reduced symptom severity, and the alpha-blocker prazosin and the tricyclic antidepressant amitriptyline improved number of responders. Overall, SSRIs were less well tolerated than placebo in both reviews (SAD Review: k = …
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