Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"praziquantel"”.
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Design of Thermosensitive Hydrogel for Extended-Release of Praziquantel
… are a severe threat to people and animals. Praziquantel is the most comanti-parasitic drug with high efficiency, and it has been used to treat parasitic diseases for many years. However, it has very strong gastrointestinal and liver metabolism that leads to a strong first-pass effect and a …
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Engagement of human host receptors by the antiparasitic drug praziquantel
… Treatment is by one broad-spectrum drug, praziquantel (PZQ) which has been the mainstay treatment for the past 40 years. PZQ is clinically administered as a racemic mixture (()-PZQ) of two enantiomers ((R)-PZQ) and (S)-PZQ). The eutomer, (R)-PZQ causes a rapid paralysis of adult …
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Use of praziquantel for treatment of flatworm parasites in centrarchid fish
… ALONG WITH MONOGENEAN AND DIGENEAN TREMATODES. PRAZIQUANTEL IS A DRUG WITH ANTI-FLATWORM ACTIVITY AND IS WIDELY USED IN HUMAN AND VETERINARY MEDICINE. AT THIS TIME PRAZIQUANTEL IS NOT APPROVED FOR THE USE IN FISH, BUT USE MAY BE JUSTIFIED UNDER THE GUIDANCE OF THE ANIMAL MEDICINAL DRUG USE …
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Embryonation and efficacy of treatments on monogenean gill flukes infecting silver kob (Argyrosomus inodorus)
… kob Argyrosomus inodorus. Treatments included praziquantel, formalin, freshwater. hydrogen peroxide and copper sulphate. Freshwater was found to be 100% effective on both species of flukes, whereas praziquantel was more effective at a higher concentration. The other treatments were not …
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Comparative and population genomic analyses of the parasitic blood flukes
… (MDA), reliant on the only available drug, praziquantel. In this thesis, I first present the results of the first genomic study investigating the potential impact of long-term mass-drug administration (MDA) on Schistosoma mansoni populations, examining these populations from within Uganda …
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Controle químico e biológico por fungos nematófagos das nematodioses gastrintestinais de equinos
… e moxidectina) e a associação de doramectina + praziquantel em equinos naturalmente infectados. A revisão teve como objetivo explorar o uso de fungos helmintófagos no controle das helmintoses em equinos, destacando seu potencial como alternativa biológica. No terceiro estudo, objetivou-se …
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The role of BATF2 during of experimental murine Schistosomiasis
… control measures are limited to treatment with praziquantel. A rather alarming situation given i) the inability of the drug to directly target the pathogenic eggs, ii) the emergence of praziquantel-resistant schistosomes, iii) the persistence of tissue fibro-proliferative destruction caused by …
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Biophysical characterisation of the interaction between the S.mansoni G4LZI3 protein and the NAD binding domain of glyceraldehyde-3 phosphate dehydrogenase
… morbidity through mass drug administration of Praziquantel (PZQ) to school-aged children and other high risk individuals. Although, the extensive use of PZQ as the main drug readily available for large scale treatment of schistosomiasis in most of African regions has raised concerns regarding …
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Impact of the parasitic helminth Schistosoma mansoni on host anti-viral vaccine responses: proof of concept from the anti-polio vaccine
… available drug for schistosomiasis control, praziquantel, the parasite-driven depletion of the plasma cell and memory T cell compartment was restored followed by a partial recovery of antibody-producing abilities in vaccinated hosts. Taken together, our findings unprecedentedly demonstrate …
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Structural Characterization of the Switch domain regions of Schistosoma mansoni druggable Adenylate cyclase-stimulating Gα-protein
… schistosomiasis. In the last three decades, praziquantel (PZQ) remains the first-line drug for the treatment of schistosomiasis. Due to drug pressure, some strains of Schistosoma mansoni has exhibited worrisome signs of resistance to treatment with PZQ. In search for a novel and/or new …
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Structural Determination of the novel Universal Stress Protein G4LZI3 from Shistosoma mansoni using X-ray Crystallography
… evidence of drug resistant strains against Praziquantel, which has been the backbone of treatment for all schistosome strains for over three decades. Furthermore, the elusiveness surrounding the mechanism of action of Praziquantel (PZQ), its lack of success in killing larval schistosomes 2-4 …
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Piperazine-based pyrido[1,2-a]benzimidazoles: synthesis and pharmacological evaluation as potential antimalarial and antischistosomal agents
… malaria, and treatment relies on a single drug: praziquantel. Although praziquantel shows multiple benefits over drugs previously used to treat schistosomiasis, dependence on it will result in therapeutic limitations and drug resistance threats. Therefore, there is a dire need to develop novel …
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Avaliação da atividade anti-Schistosoma mansoni de novos ftalimido-tiazóis
… um é indicado para o tratamento em massa, o praziquantel. Além de possuir gosto amargo e uma série de efeitos colaterais, há relatos de possível resistência de algumas cepas ao princípio ativo e uma baixa adesão da população ao tratamento. Mediante os fatos acima, a busca por novos fármacos …
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Desenvolvimento e avaliação da atividade esquistossomicida de dispersões sólidas à base de LQIT/LT-50 e LQIT/LT-51
… as doenças negligenciadas do mundo, onde o Praziquantel é o medicamento mais utilizado no mundo para o tratamento dessa doença, porém seu uso exclusivo pode ocasionar o desenvolvimento de uma possível resistência dos vermes de Schistosoma mansoni. Para aumentar o controle e a contenção da …
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Novas moléculas imidazolidínicas: potenciais candidatas a fármacos esquistossomicidas
… é feita apenas com um único fármaco, o praziquantel, ativo contra todas as espécies de Schistosoma, e o oxamniquina ativo apenas contra o Schistosoma mansoni. Contudo há relatos na literatura de resistência do parasito ao tratamento para os dois fármacos, gerando uma preocupação a nível …
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Identification and structural bioinformatics of druggable proteins in schistosoma species
… to the widely accepted first-line drug-of-choice Praziquantel (PZQ). Therefore, the present study describes the exploration of broad-spectrum therapeutic potentials of Antimicrobial peptides (AMPs) in the design of alternative anti-schistosomal treatment regimen. AMPs are natural antibiotics …
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Molecular cloning, recombinant protein expression and structural characterization of a universal stress G4LZI3 protein from Schistosoma mansoni
… drug for the treatment of schistosomiasis is praziquantel which has various limitations and of late, drug resistance. The limitations of this first line drug has made it necessary for alternative interventions for combating the disease in terms of novel drugs and vaccines discovery and …
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Antischistosomal structure-activity relationships of nitrated n-phenyl benzamide derivatives.
… being the most prevalent. For over 40 years, praziquantel has stood out as the principal drug of choice in the treatment and control of schistosomiasis. It is efficacious and safe. It has also been very instrumental in preventive chemotherapy. However, it faces emerging drug resistance, lacks …
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Antischistosomal structure-activity relationships of nitrated n-phenyl benzamide derivatives.
… being the most prevalent. For over 40 years, praziquantel has stood out as the principal drug of choice in the treatment and control of schistosomiasis. It is efficacious and safe. It has also been very instrumental in preventive chemotherapy. However, it faces emerging drug resistance, lacks …
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Avaliação da atividade do complexo de inclusão da βlapachona em ciclodextrina frente ao Schistosoma mansoni
… surgimento de cepas resistentes ou tolerantes ao praziquantel (PZQ), bem como a sugestiva atuação esquistossomicida da β-lap, nos impeliram a avaliar a atuação in vivo desta naftoquinona complexada em 2-O-metil-β-ciclodextrina (MβCD) sobre o S. mansoni (modelo murino). Os camundongos foram …
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