Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"pramipexole"”.
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Antidepressant effect of pramipexole in a dexamethasone induced depressive-like behavior model
Resumo: A depressão é um distúrbio psiquiátrico comum caracterizado por diversos sintomas debilitantes como a desesperança e a anedonia. Apesar de a fisiopatologia do distúrbio ainda não estar completamente elucidada, evidências demonstram a associação entre a depressão e disfunções do sistema …
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Influence of Pramipexole on Probability Discounting and Ventral Pallidal Function: Assessments in Parkinsonian-Like Rats
… the time this dissertation was being developed, pramipexole was the drug, gambling was the behavior, and Parkinson's disease (PD) was the pathology most widely reported for this phenomenon. Therefore, we first developed a behavioral paradigm (i.e., probability discounting) to measure risk-taking, …
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50-kHz ultrasonic vocalizations in hemiparkinsonian rats repeatedly treated with dopaminomimetic drugs as a possible behavioral marker of the affective properties of dopamine-replacing therapy in Parkinson's disease
… (L-DOPA, 6 or 12 mg/kg, i.p.), or pramipexole (2 or 4 mg/kg, i.p.) were administered in a test cage (× 5 administrations) on alternate days. Seven days after treatment discontinuation, rats were re-exposed to the test cage to measure conditioned calling behavior and thereafter …
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Gut-brain axis: Central impact of gut peptides and metabolic drug on monoamine neurotransmission
… (a dopamine D2/D3 receptor agonist) and pramipexole (a dopamine D3 preferred receptor agonist) -induced yawning, pica eating and pelvic grooming activities, as well as phencyclidine ( an N-Methyl-D-aspartate receptor antagonist)-induced cognitive deficit. We also examined the …
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Innovative analytical methods for Central Nervous System Drug analysis in biological fluids
… (vigabatrin and topiramate) and antiparkinsons (pramipexole). Innovative methods based on liquid chromatography or capillary electrophoresis coupled to diode-array or laser-induced fluorescence detectors have been developed, together with the suitable sample pre-treatment for interference removal …
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Meccanismo d'azione del Pramipexolo nella terapia della malattia di Parkinson
Pramipexole (PPX) is a dopamine (DA) D3 and D2 receptors agonist widely used alone or in combination with levodopa as Dopamine Replacement Therapy in Parkinson’s disease. In clinical and preclinical studies, PPX improved motor deficits, this evidence led to lowering daily dose of levodopa, delaying …
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The Deconstruction of Reinforcement Learning in Human Substance Use Disorder
… (400mg amisulpride) and agonist (0.5 mg pramipexole) differentially modulated behaviour in stimulant-addicted individuals: while both dopamine agents impaired performance in control participants, they ameliorated learning from negative feedback in stimulant-addicted individuals – …