Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 123 for “"potential treatment"”.
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Insulin resistance, chronic heart failure and potential treatment
… dysfunction and hyperinsulinaemia are potential explanations of the development of IR in CHF. Additionally, it remains to be determined if IR is merely a marker reflecting the severity of CHF or whether it contributes to the disease in CHF. If IR is truly a culprit that worsens CHF, …
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Identification of genipin as a potential treatment for type 2 diabetes
… several therapies for T2D, there is no effective treatment that can reverse the functional decline of pancreatic β cells in T2D patients. Glucagon-like peptide-1 (GLP-1) is a peptide hormone secreted by human intestinal L cells, which can stimulate the proliferation and differentiation of β cells …
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Investigation of extracorporeal immobilized enzyme device : a potential treatment for blood deheparinization
Thesis (Sc.D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 1999.
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Characterizing Changes in the Brain During Hydrocephalic Development and Exploring Potential Treatment Strategies
… of the brain. Thus, the only available treatments are surgical, invasive, and prone to complications. There is a global need for successful treatment strategies without brain surgery. Choroid plexus epithelial cells (CPEC) are responsible for production of cerebrospinal fluid (CSF). …
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Assessing the acetylcholinesterase inhibitory potential of novel pharmacophores for potential treatment of Alzheimer’s disease
… target in drug discovery and development for the treatment of AD. However, an overall attrition rate of more than 95% has been noted for novel drugs targeting neurodegenerative diseases, and this is mainly due to a lack of efficacy, blood-brain barrier (BBB) permeability, multifactorial nature …
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Preformulation Characterization And Formulation Development of Δ9-Tetrahydrocannabinol Prodrugs For Potential Treatment Of Glacuoma
… been concluded whether THC is effective in the treatment of glaucoma or not. Current therapy for IOP control in glaucoma, though effective, cannot prevent vision loss completely. Thus, identification of agents that can lower IOP as well as protect the retinal ganglion cells from apoptosis could …
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Target Based Design And Synthesis of Heterocycles in the Potential Treatment of Cancer and Opportunistic Infection
… relevant to cancer chemotherapy as they have the potential to overcome multidrug resistance and dose limiting toxicities. Antiangiogenic agents target tumor angiogenesis, an important phenomenon for tumor growth and metastasis. The angiogenic effect is mediated by receptor tyrosine kinases (RTKs) …
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Development of SiRNA Incorporated Surface Modified Polymeric Nanoparticle for the Potential Treatment of Global Cerebral Ischemia
… cognitive deficits. RNAi technology has the potential to overcome the limitations of current therapies. siRNA can specifically degrade the BRD4 mRNA, consequently suppressing the BRD4 expression, thereby protecting neurons from neuroinflammation. However, the blood-brain barrier (BBB) causes …
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Design and Synthesis of Pyrimidine Based Fused Heterocyclics in the Potential Treatment of Cancer and Opportunistic Infection
… <em>Pneumocystis jirovecii</em>. The current treatment involving the use of a combination of trimethoprim and sulfamethoxazole is limited by drug resistance, treatment failures and adverse side effects. Newer drugs are critically needed for patients, unresponsive or resistant to this …
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Target Based Design and Synthesis of Fused Pyrimidines in the Potential Treatment of Cancer and Opportunistic Infection
… and multiple receptor tyrosine kinase (RTK) for potential treatment of cancer; and (c) substrates for tumor-targeted therapy for cancer.</p> <p>PCP is a host species-specific infection. Most of the drugs, synthesized and evaluated so far, have been tested against <em>Pneumocystis carinii</em> …
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Tinnitus, physical activity and improved quality of life: investigation of the neural correlates of tinnitus and potential treatment options
Objectives. The objectives of the dissertation are to (1) identify the neural correlates of tinnitus distress and successful habituation, and (2) investigate any relationship between physical activity and tinnitus distress. Subjective tinnitus, commonly referred to as ringing in the ears, is the …
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A fluidized immunoadsorption device for removing beta-2-microglobulin from whole blood : a potential treatment for dialysis-related amyloidosis
Dialysis-related amyloidosis (DRA) is a frequent complication of end-stage renal disease that has been associated with the accumulation of 2-microglobulin (2m). Excluding transplantation, existing kidney replacement technologies are believed to remove insufficient quantities of P2m for the …
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Determining the in vitro anti-cancer effects of various novel indoles and an anti-microbial peptide towards a potential treatment of glioma.
… as a starting point for the development of new treatments against glioma. Investigation began on determining the anti-cancer activity of a variety of indoles against glioma cell lines (1321N1 and U87MG) using a number of different cell-based assays and also to compare them with conventional …
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Social cognitive impairments Arc gene implication and ketamine as a potential treatment [Deficits socio-cognitivi Coinvolgimento del gene Arc e ketamina come potenziale trattamento]
Le interazioni sociali rivestono un'importanza fondamentale nella vita di ogni essere vivente. Queste interazioni sono regolamentate da una sofisticata rete di processi cognitivi che coinvolgono specifiche aree cerebrali conosciute come il cervello sociale. Una componente cruciale dell'interazione …
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Part I: Disruption of PTEN-5-HT2CR Coupling: A Potential Treatment for Restoration of 5-HT2CR Function / Part II: Rapid Total Synthesis of Cyclodepsipeptide MA026
PART I Serotonin 2C receptor (5-HT2CR) plays an important role in regulation of physiology, behavior, and dysfunction in 5-HT2CR neurotransmission may underlie some psychiatric disorders (e.g., depression, drug addiction). The association of the 5-HT2CR with protein phosphatase and tensin homologue …
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Development of dry powder Inhaler and nebulised nanoparticles formulations of chrysin for the potential treatment of asthma. Development of dry powder inhaler of chrysin and nebulised nanoemulsion combination of chrysin and budesonide; Evaluating the anti-inflammatory activity of the combination formulation of chrysin and budesonide for asthma
… and an anti-inflammatory study confirmed the potential for chrysin to be used with budesonide in a combined formulation; thus, chrysin’s anti-inflammatory efficacy can be improved and the required inhaled dose can be reduced.
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Development of a Dry Powder Inhaler and Nebulised Nanoparticle-Based Formulations of Curcuminoids for the Potential Treatment of Lung Cancer. Development of Drug Delivery Formulations of Curcuminoids to the Lungs using Air Jet Milling and Sonocrystallisation Techniques for Dry Powder Inhaler Preparations; and Nanoemulsion and Microsuspension for Nebuliser Formulations
Curcuminoids have strong anticancer activities but have low bioavailability. The highest rate of cancer deaths comes from lung tumours; therefore, inhaled curcuminoids could treat lung cancer locally. To date, there are no nebulised formulations of curcuminoids, and there are no inhalable …
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EVALUATING TREATMENT HETEROGENEITY IN THE COMMUNITY MEDIATION MARYLAND RE-ENTRY PROGRAM
… recidivism, but given the varied nature of the treatment, important questions remain. This thesis investigates potential treatment heterogeneity based on the subjects’ selection into different formats of the mediation process (i.e., selection of outside participants, focusing on emotional …
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Development of nanosponges from erythrocyte ghosts for removal of streptolysin-O and α haemolysin from mammalian blood
… from mammalian erythrocyte ghosts, as a potential treatment for toxin related sepsis.
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