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Showing 1 to 8 of 8 for “"potassium ion channels"”.
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RCK Domain Model of Calcium Activation in BK Channels
<p>Potassium ion channels are ubiquitously expressed from bacteria to mammals where they are involved in various processes ranging from the regulation of osmotic pressure in a single cell to the electrical response in muscle fibers to the generation of action potentials in neurons. The BK channel …
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Discovery, bioactivity evaluation and rational design of natural-occurring peptides from Agalychnis annae and Rana tagoi okiensis
There are multiple biofunctional peptides in amphibians which assist in their survival in diverse environments. Many bioactive peptides from this source were found to have the potential to be developed into new drugs in the future. In this thesis, two peptides found in frogs and their analogues …
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Trafficking motifs in potassium channels
The pancreatic ATP-sensitive potassium (KATP) channels couple glucose metabolism to excitability of the pancreatic β-cells to regulate insulin secretion. The channel subunits, Kir6.2 and SUR1, are encoded by the KCNJ11 and ABCC8 genes respectively. Genetic polymorphisms in these genes, which reduce …
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Molecular Basis of Mechanosensitivity
<p>Mechanosensation is arguably the least understood of all senses. For most physiological processes, the first response to membrane stress is thought to be the opening or closing of mechanosensitive channels, but the clonal nature of the first mechanotransducers is still largely unknown. The …
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Characterization of the Central Cavity of a Potassium Channel: Helix Dipoles, Conformational Plasticity and Inhibition
<p>Potassium channels are important for regulating the flow of potassium ions across semi-permeable cell membranes in an efficient and selective manner. Potassium channels form a conduction pore comprised of a selectivity filter responsible for the strong preference for potassium, and a …
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The Structural and Functional Analysis of a Voltage-Dependent Potassium Channel
<p>Voltage-dependent ion channels are finely tuned to open and allow ion conduction in response to changes in the membrane voltage, a function that lies at the heart of nerve impulse generation and propagation. These channels contain transmembrane voltage-sensing domains that contain highly …
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A Pharmacological Analysis of the Ionic Channels of Nerve
… model of Hodgkin and Huxley. The sodium, the potassium, and the leakage current components and the time constants associated with their changes were calculated. Tetrodotoxin abolished the sodium currents selectively, and tetraethylammonium ion abolished the potassium currents selectively. …
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Computational analyses on the structure-function relation in ion channels
Ion channels are protein molecules, embedded in the lipid bilayer of the cell membranes. They act as powerful sensing elements switching chemicalphysical stimuli into ion-fluxes. At a glance, ion channels are water-filled pores, which can open and close in response to different stimuli (gating), …