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Showing 1 to 20 of 84 for “"potassium channel"”.
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Biogenesis and Traffic of the Potassium Channel
… cells depends on the number and the types of ion channels expressed at the plasma membrane. This work examines aspects of biogenesis and traffic of the Shaker voltage-gated potassium channel. Shaker is an oligomeric, polytopic membrane protein and, as such, its biogenesis begins at the endoplasmic …
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The structure of a voltage gated potassium channel
Voltage gated potassium channels (Kv channels) are tetrameric ion channels, responsible for regulating the potassium component of the membrane potential in a large range of cell types ranging from mammalian excitable cells to bacteria. Attempts have been made to elucidate the structure of voltage …
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Identification of potassium channel subtypes mediating the PGE2-induced sensitization of sensory neurons and regulation of potassium channel gene expression by chronic inflammation
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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The Structural and Functional Analysis of a Voltage-Dependent Potassium Channel
<p>Voltage-dependent ion channels are finely tuned to open and allow ion conduction in response to changes in the membrane voltage, a function that lies at the heart of nerve impulse generation and propagation. These channels contain transmembrane voltage-sensing domains that contain highly …
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GPCR Activation of the G Protein-Gated Inward-Rectifier Potassium Channel
… receptors (GPCRs), which in turn activate ion channels that modify the electrical properties of cardiac pacemaker cells. Sympathetic stimulation accelerates heart rate through activation of beta-adrenergic receptors (βARs), which open excitatory ion channels through the stimulatory G protein …
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Recombinant Expression In Pichia pastoris System Of The Potassium Channel Inhibitor Peptide, Ts6.
… potent venomous peptides is known to block ion channels, yet diseases that have a scope of being treated have not been discussed. In this study, Ts6 which has proven blocking activity in Kv1.3 has been analyzed recombinantly for Kv1.5 and Kv1.3. This toxin (Ts6) purified from Tityus serrulatus …
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Analysis of ether-à-go-go potassium channel (Eag1) splice variants in melanoma cells
Der menschliche Ether-à-go-go Kaliumkanal (hEag1) nachgewiesen werden in adulten Gehirn und in beiden Tumorzelllinien und primären Tumoren. Das physiologische Funktion dieses Kanals im Gehirn bleibt zu aufgeklärt. Die Anwesenheit von hEag1 in Tumoren hat zu einem Anstieg in Verbindung gebracht …
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Characterization of the Central Cavity of a Potassium Channel: Helix Dipoles, Conformational Plasticity and Inhibition
<p>Potassium channels are important for regulating the flow of potassium ions across semi-permeable cell membranes in an efficient and selective manner. Potassium channels form a conduction pore comprised of a selectivity filter responsible for the strong preference for potassium, and a …
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Functional and Biochemical Characterization of KCNQ1/KCNE1 Subunit Interactions in the Cardiac IKs Potassium Channel
The IKs potassium channel, critical to control of heart electrical activity, requires assembly of pore-forming alpha subunits (KCNQ1) and accessory beta (KCNE1) subunits. IKs is the slowly activating component of delayed rectifier K+ current in the heart and is a major contributor to the timing of …
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Effect of charge alterations on C- and N-terminal domains of the inward rectifying potassium channel.
… and N-terminal domains of the inward rectifying potassium channel.
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Mechanistic studies of ion binding and inactivation in the potassium channel KcsA by solid state NMR
The prototypical prokaryotic channel, KcsA, is model system for mammalian potassium channels. This thesis describes solid-state NMR studies of the conformational dynamics involved in ion binding and channel inactivation. Our studies are conducted on the full-length wildtype channel incorporated …
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Decreased transmitter release conferred by a mutation in the slowpoke-encoded calcium-dependent potassium channel gene at the Drosophila neuromuscular junction
… in the structural gene for a calcium activated potassium channel, slowpoke (slo), in Drosophila melanogaster were studied. Anti-horseradish peroxidase was used to visualize the branching of the nerves innervating the body wall muscles. No differences are observed between slo and normal larvae. …
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Chlorellavirus-Proteine: I. Die Hüllprotein-Genfamilie II. Ein primitiver Kaliumkanal
… strains Pbi and NC64A.Part II: A primitive potassium channel Kcv is a viral protein 94 amino acids in length, which posesses the typical properties of a potassium channel. Kcv induces a weakly voltage dependent, potassium-selective conductance in Xenopus laevis oocytes, which is inhibited by …
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The Role of CREB in Social Isolation and Natural Reward Behavior
… alone increases expression of several types of potassium channels in the nucleus accumbens. Investigating the electrophysiological properties of these neurons, social isolation results in a greater hyperpolarization of the resting membrane potential, and decreased potassium channel-mediated …
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Studies on the stimulant action of human gamma-globulin on spontaneous contractility: interaction with K⁺-channel openers and postaglandin inhibitors
… rat mesenteric portal vein is due to decreased potassium conductance. The aim of the third study was to determine if prostaglandins play a role in the stimulatory effects of human gamma-globulin. Human gamma-globulin significantly increased the contractile activity of spontaneously-active …
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Voltage-Gating Mechanism in Potassium Channels
"Voltage-gated potassium channels are membrane proteins that regulate the flow of K+ ions across the cell membrane. These channels respond to changes in electrostatic potential across the cell membrane, and allow passage of K+ ions through their conduction pore. In excitable cells, an interplay of …
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Voltage-Gating Mechanism in Potassium Channels
Voltage-gated potassium channels are membrane proteins that regulate the flow of K+ ions across the cell membrane. These channels respond to changes in electrostatic potential across the cell membrane, and allow passage of K+ ions through their conduction pore. In excitable cells, an interplay of …
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Regulation of Volume by Spermatozoa and Its Significance for Conservation Biology
… the movement of osmolytes through various channels, including potassium channels. The potassium channels involved in volume regulation of human, monkey, and murine spermatozoa were investigated. Flow cytometry was used to gauge the sensitivity of the volume regulatory process of spermatozoa …
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