Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"posttranscriptional regulation"”.
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Investigation Of Posttranscriptional Regulation After Global Brain Ischemia And Reperfusion Injury
… neurons and to characterize global translation regulation, we 1) prevented mRNA granule formation in reperfused neurons or induced mRNA granules in uninjured neurons by pharmacological manipulation polysomes, 2. studied potential HuR posttranscriptional regulation mechanisms of facilitated …
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Posttranscriptional regulation with regard to cleavage factor I (CFI) associated alternative polyadenylation and methyltransferase A (MTA) assisted m6A modifications in Arabidopsis thaliana
Changing the expression of genes, posttranscriptional modifications and other regulatory pathways enable rapid adaption to both mild and extreme conditions in all domains of life. Recent research improved the understanding of posttranscriptional modifications, which are affecting the fate of a …
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Analysis of Medicago truncatula transcription factors involved in the arbuscular mycorrhizal symbiosis
… is known to be affected by phosphate, the posttranscriptional regulation might represent a link between phosphate signaling and arbuscule development. In this work, the posttranscriptional regulation was confirmed by mis-expression of miRNA5204* in M. truncatula roots. The miRNA-mediated …
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Epigenetic and post-transcriptional regulation of gene expression in pluripotent stem cells, differentiation and metastasis
… details. Through the study of epigenetics and posttranscriptional regulation of gene expression by high-throughput sequencing technologies in several biological processes, namely embryonic stem cells, somatic reprogramming, erythroid differentiation, epithelial-mesenchymal transition and cancer …
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KSHV encoded viral processivity factor, ORF59, regulates multiple pathways for viral replication
… (MTA) viral early protein involved in posttranscriptional regulation, splicing of viral RNA transcripts, RNA stability, and transcriptional activation, bound specifically to ORF59. ORF59 also associated with minichromosome maintenance proteins (MCMs), a complex of DNA replication …
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Understanding regulation of mRNA by RNA binding proteins
Posttranscriptional regulation of mRNA by RNA-binding proteins plays key roles in regulating the transcriptome over the course of development, between tissues and in disease states. The specific interactions between mRNA and protein are controlled by the proteins' inherent affinities for different …
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TNFalpha expression in monocytes/macrophages
… are a decrease in gene transcription as well as posttranscriptional inhibition. Okadaic acid, a protein phosphatase inhibitor, seems to overcome the posttranscriptional inhibition exerted by dexamethasone when TNF expression is induced. The posttranscriptional regulation of TNF was further …
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Multiple virulence genes and other MRNA regulatory targets are differentially expressed in two Helicobacter pylori strains overexpressing small RNAs
… associated cytotoxin, CagA. Although the genetic regulation necessary for these and other virulence traits is complicated by a relative lack of regulatory proteins in H. pylori, its wealth of small RNAs (sRNAs) may also regulate mRNAs, including in the cagPAI. The nascent body of work in H. pylori …
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Regulatory RNAs at the Heart of Sugar Metabolism: New Mechanisms and Novel Discoveries
Bacteria are adept at using a variety of posttranscriptional strategies to regulate gene expression. Specifically, various RNA-mediated genetic control elements have been discovered in the past decade through a combination of genetics, bioinformatics, and transcriptomic approaches. Together, these …
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Post-transcriptional regulation of vibrio cholerae virulence activator toxt
… illness cholera, uses a complex array of gene regulation to induce its virulence determinants. During the early stage of infection, and upon response to unknown signals, virulence genes are turned on. ToxT protein is the primary virulence gene transcription activator. Once ToxT is produced, it …
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MiR-145 is a tumor suppressor in both tumor progression and metastasis
… these results define the role of miR-145 in the posttranscriptional regulation of c-Myc by p53. in addition, we show that miR-145 exerts its growth inhibitory function in a cell-specific manner. Although miR-145 inhibits cell growth in MCF-7 and HCT-116 cells, it has no significant effect on cell …
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Transcript leaders : annotation and insight into functions in translation
… and are regulated for a given gene in vivo. Posttranscriptional regulation is carried out primarily through the noncoding portions of the mRNA: the Transcript Leader (TL or 5'UTR) upstream of the Open Reading Frame (ORF), and the 3'Untranslated Region (3'UTR) downstream. To understand how …
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Genetics and physiology of motility by Photorhabdus spp
… imply that NaCl and KCl regulate motility posttranscriptionally and not at the gene expression level. This ionic salt posttranscriptional regulation of motility has not been observed in other bacteria. We suggest that this form of regulation may be beneficial for an organism that must adapt …