Global ETD Search
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Showing 1 to 6 of 6 for “"posttranscriptional modification"”.
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Mechanism of mRNA localisation and posttranscriptional modification in Drosophila melanogaster embryonic neurons
In recent years it has become apparent that neuronal development and function relies not just on the regulation of transcription but also on post-transcriptional events. Two prevalent mRNA-based regulatory mechanisms in neurons are asymmetric mRNA localisation and the generation of different 3’UTR …
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Bst2 Isoforms: Distribution and Potential Use In Cancer Therapeutics
… different BST2 isoforms of BST2 generated by posttranscriptional modification. In this research, I studied the long BST2 isoform’s distribution in breast tissue and B cell lines using the novel monoclonal antibody (MAb) LA5, an anti-BST2-long MAb. This approach revealed the expression of the …
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Characterization of the Role of Differential Gene Expression and RNA Editing in Drosophila Tonic and Phasic Motoneuron Diversity
… classes. Next, I analyzed how a specific type of posttranscriptional modification, RNA editing, was differentially regulated across the transcriptome in each neuronal subtype. Out of ~14,000 genes in the Drosophila genome, only a small number (324 sites in 215 genes) were canonically RNA edited at …
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Computational analysis of regulatory networks using genome-scale data
… DNA-RNA transcription step to post-translational modification of a protein. The main stages where gene expression is regulated are chromatin domains, Transcription, Posttranscriptional modification, RNA transport, Translation, mRNA degradation and Post-translational modifications. Understanding …
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Characterizing Modified Nucleosides in RNA by LC/UV/MS
<p>Posttranscriptional nucleoside modification is an important characteristic in all types of ribonucleic acids (RNA) and increases the functional diversity of RNA, exceeding that of the four canonical bases. In ribosomal RNA (rRNA) and transfer RNA (tRNA) these modifications enhance RNA structure …
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Posttranscriptional regulation with regard to cleavage factor I (CFI) associated alternative polyadenylation and methyltransferase A (MTA) assisted m6A modifications in Arabidopsis thaliana
Changing the expression of genes, posttranscriptional modifications and other regulatory pathways enable rapid adaption to both mild and extreme conditions in all domains of life. Recent research improved the understanding of posttranscriptional modifications, which are affecting the fate of a …