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Showing 1 to 20 of 30 for “"postsynaptic density"”.

  1. Developmental Changes In The Structure and Composition of The Postsynaptic Density

    Swulius, Matthew T2010

    … in one of its most prominent components, the postsynaptic density (PSD), have largely evaded observation. The PSD is a protein-rich organelle on the cytoplasmic side of the postsynaptic membrane, where it sits in direct opposition to the presynaptic terminal. The PSD functions both to cluster …

    uthsc Repository record

  2. The Neurobiology of Motor Skill Learning: Structural Adaptation Within Sensorimotor Regions of the Rat Brain

    Kleim, Jeffrey AllanUniversity of Illinois at Urbana-Champaign2015

    … animals that included significant increases in postsynaptic density (PSD) length, number of synapses with perforated PSDs as well as number of synapses forming multiple synaptic contacts. Finally, an examination of the gross morphology of the red nucleus revealed no significant change in …

    uiuc Repository record

  3. Impaired and enhanced spatial representation of the PSD-95 knockout mouse

    Sun, Linus Da-Shih, 1972-Massachusetts Institute of Technology2004

    Postsynaptic density protein-95 (PSD-95) is the second most abundantly expressed synaptic protein in the postnatal forebrain. It is an integral part of the postsynaptic scaffolding complex and helps recruit receptors, channels and associated factors involved with synaptic transmission. A mouse …

    mit Repository record

  4. Spatially restricted proteomic mapping of excitatory and inhibitory post-synaptic termini through enzymatic labeling

    Cox, Kurt J. (Kurt James)Massachusetts Institute of Technology2016

    … (excitatory) and GABAergic (inhibitory) postsynaptic densities. In doing so, we provide the first selective and comprehensive survey of the inhibitory postsynaptic density, which has eluded purification by conventional biochemical methods. Furthermore, we demonstrate the use of APEX in …

    mit Repository record

  5. Regulation of synaptic function and plasticity by cyclin-dependent kinase 5

    Su, Susan C. (Susan Chih-Chieh)Massachusetts Institute of Technology2013

    … neurotransmission. Finally, we identified the postsynaptic density protein Shank3 as a Cdk5 substrate and observed that Cdk5-mediated phosphorylation of Shank3 plays a critical role in maintaining dendritic spine morphology and synaptic plasticity. Our collective results demonstrate a central …

    mit Repository record

  6. In vivo visualization of CaMKII activity in ocular dominance plasticity

    Kwok, Show MingMassachusetts Institute of Technology2009

    … kinase II (CaMKII) is a major component of the postsynaptic density. Activation of CaMKII is necessary and sufficient for LTP induction, is required for OD plasticity, and its expression pattern coincides with the site of rapid plasticity in the supragranular layers II/III of the visual cortex. …

    mit Repository record

  7. A Potential Role For Sap97 In Psychiatric Disorders

    Gupta, Preetika2018

    … (MAGUKs), that are highly enriched in the postsynaptic density of synapses and play an important role in organizing protein complexes necessary for synaptic development and plasticity. Large-scale genetic studies have implicated MAGUKs in neuropsychiatric disorders such as intellectual …

    penn Repository record

  8. Enhanced striatal glutamatergic function upon chronic antipsychotic action

    Vernon, Amanda, Ph. D. Massachusetts Institute of Technology.Massachusetts Institute of Technology2019

    … increases in components of the glutamatergic postsynaptic density. Subsequent functional experiments demonstrated the presence of calcium-permeable AMPARs and increased mEPSC frequency following chronic administration of one especially effective antipsychotic, clozapine. Furthermore, we find …

    mit Repository record

  9. Ultrastructure and morphometric analysis of hippocampal synapses in the Fmr1-/y mouse model of fragile X syndrome

    Weiser Novak, Samuel2015

    … synaptic components (presynaptic vesicles and postsynaptic densities) were included in our morphological analyses. We observed no changes in postsynaptic density length (DG: 5.69±0.30/6.18±0.85; SR: 7.55±0.87/6,96±0.33 µm/100 µm2; p=0.627/0.620), synapse density (DG: 32.3±3.8/30.3±1.9; SR: …

    uvic Repository record

  10. Somatostatin Receptor 2 Regulation By C-Terminal Motifs and Pdz Domain Proteins

    Olsen, Courtney, <p><a href="https://urldefense.proofpoint.com/v2/url?u=http-3A__orcid.org_0000-2D0003-2D2685-2D0217&d=AwMCAA&c=6vgNTiRn9_pqCD9hKx9JgXN1VapJQ8JVoF8oWH1AgfQ&r=GknWj9_z-7Lf06QrGl-rnjILCN_6eU749v5kKmPni2o&m=M-4it7geQ4Yw40n9p4Gsg0rPRIcOBNZfybcsBSJ72v4&s=vcK31Ot4St4iQ7uGkxEp2P65w-sgO5w82ADz4htasrc&e=" target="_blank">0000-0003-2685-0217</a></p>2019

    … patients fail to respond to these agonists. As Postsynaptic density protein/Discs large-1/Zona occludens-1 (PDZ) domain interactions often regulate the trafficking and signaling potential of other GPCRs, we examined the role of the sst2 PDZ ligand and additional C-terminal residues in …

    uthsc Repository record

  11. Structure and Composition of Postsynaptic Densities

    Farley, Madeline2015

    … is controlled by both presynaptic and postsynaptic mechanisms and is termed synaptic plasticity. One postsynaptic structure postulated to regulate synaptic strength is the postsynaptic density (PSD), a large electron dense protein complex located just below the synaptic membrane. The …

    uthsc Repository record

  12. Three-Dimensional Single-Molecule Localisation Microscopy and Visualisation Techniques

    Handa, AnoushkaUniversity of Cambridge2022

    … organisation of a scaffolding protein known as postsynaptic density 95 (PSD95). PSD95 is known to form nanoclusters which make up the basic structural unit of an excitatory synapse, however, through the sensitivity of 3D DH-PSF imaging, we were able to observe the presence of diffuse PSD95 …

    cambridge Repository record

  13. The serotonin (5-HT) 2C receptor (5-HT2CR) and its downstream signaling components: Distinct adaptations in cortical circuits associated with cocaine exposure

    Maria Fe LanfrancoThe University of Texas Medical Branch2009

    … 3) expression and subcellular localization of postsynaptic-density (PSD) protein-95 (PSD-95); and 4) phosphorylation of p44/p42-mitogen-activated protein kinases (p44/p42-MAPK), which influences activity of molecules involved in 5 HT2CR trafficking. We found decreased 5 HT2CR protein expression …

    utmb Repository record

  14. NMDAR-PSD95-nNOS Axis-Mediated Molecular Mechanisms in the Basolateral Amygdala Underlying Fear Consolidation

    Patel, Jheel2021

    … (nNOS) to the synaptic scaffolding protein, postsynaptic density protein 95 (PSD95), to produce nitric oxide (NO). Our laboratory has previously shown that disruption of the PSD95-nNOS interaction attenuates fear consolidation and impairs long-term potentiation of basolateral amygdala (BLA) …

    iupui Repository record

  15. Organization of Postsynaptic Proteins via the Neuronal Cytoskeleton

    Allison, Daniel WardUniversity of Illinois at Urbana-Champaign2015

    … for anchoring molecular components of postsynaptic specializations in the mammalian brain are not well understood but are presumed to involve associations with cytoskeletal elements. We used cytoskeletal perturbing agents and detergent extraction of primary hippocampal cultures to test …

    uiuc Repository record

  16. Super-resolution imaging of glutamate receptors trafficking at live synapses

    Cai, EnUniversity of Illinois at Urbana-Champaign2014

    … Located on the tip of postsynapse is the postsynaptic density (PSD) that receives signals (neurotransmitters) from presynapse via glutamate receptors, mainly AMPA receptors and NMDA receptors. Trafficking of AMPA receptors in and out of synapses affect synaptic plasticity, which underlies …

    uiuc Repository record

  17. Charakterisierung von Somatostatinrezeptor-Subtyp 4 interagierenden Proteinen in der Ratte (Rattus norvegicus)

    Christenn, MarcusUniversität Würzburg

    … interagieren. Sowohl PSD-95 als auch PSD-93 (Postsynaptic density protein of 95 kDa bzw. 93kDa) wurden mit einem immobilisierten Peptid präzipitiert, das die neun C-terminalen Aminosäuren des SSTR4 enthält. Die Interaktion des SSTR4 mit PSD 95 wurde im Weiteren näher charakterisiert. In einem …

    wurz-thes Repository record

  18. Synaptome mapping of glutamatergic synapses across the mouse brain

    Cizeron, MélissaThe University of Edinburgh2017

    … are specialised contacts between neurons. At postsynaptic terminals of glutamatergic synapses, protein complexes process and transmit the information received from the presynaptic terminal. Scaffolding proteins, among which members of the disc large homologue (DLG) family are the most …

    edinburgh Repository record

  19. The investigation of the neuronal and synaptic defects in early stage of amyloid-beta pathology

    Yook, YeeunUniversity of Illinois at Urbana-Champaign2024

    … the molecular mechanism by which A elevates postsynaptic density protein 95 (PSD-95), promoting seizure response in young APP/PS1 mice. This elevation results from reduced ubiquitination caused by Akt-dependent phosphorylation of E3 ubiquitin ligase murine-double-minute 2 (Mdm2). PSD-95 is …

    uiuc Repository record

  20. Regulation of synaptic structure and function at the Drosophila neuromuscular junction

    Blunk, Aline D. (Aline Dorret)Massachusetts Institute of Technology2013

    … release from synaptic vesicles and activation of postsynaptic receptors. Structural remodeling of synaptic connections can strengthen neuronal communication and synaptic efficacy during development and behavioral plasticity. Here, I describe experimental approaches that have revealed how the actin …

    mit Repository record

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