Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 5 of 5 for “"postmitotic neurons"”.
-
Regulation of neuronal genomic integrity through histone deacetylase cooperativity
… proliferating cells, corresponding pathways in postmitotic neurons remain poorly understood. In this report, I characterize the functions of two lysine deacetylases, SIRT1 and HDAC1, in the neuronal response to DNA double strand breaks (DSBs). Both SIRT1 and HDAC1 were previously shown to …
-
Genetic analysis of the maintenance of neuronal morphology in Drosophila melanogaster
… be required to maintain nuclear position within postmitotic neurons.
-
Developmental Dynamics of 5-Hydroxymethylcytosine and its Role in the Terminal Differentiation of Neurons
… in depth, little is known about how postmitotic neurons regulate their chromatin state. Modulation of transcription through the regulation of accessibility of transcription factor binding sites is essential for the regulation of migration, synapse formation and terminal …
-
Postmitotic Dynamics in Chromatin Modification and Regulatory Topology Underlie Cerebellar Granule Maturation
<p>Neurons are remarkably long-lived cells that are born early on in development and maintained over the lifespan of an organism. Their birth is followed by their iterative maturation into functional neurons that can participate in CNS circuitry. This involves the temporally regulated programs of …
-
Postnatal Role for Histone Deacetylase 1 and 2 in Behavioral and Neuronal Homeostasis
… suggesting redundant functions of these HDACs in postmitotic neurons. Finally, after observing and characterizing an excessive grooming phenotype in conditional HDAC1/2 double knockout mice we mechanistically attributed this phenotype to dysregulation of SAP90/PSD-95-associated protein 3 (SAPAP3), …